STRINGSTRING
ML1123 ML1123 ML0049 ML0049 ML0050 ML0050 ML0051 ML0051 sodA sodA ML0131 ML0131 ML0269 ML0269 ML0348 ML0348 ML0363 ML0363 ML0369 ML0369 ML0411 ML0411 bcp bcp secD secD secF secF ML0489 ML0489 PPE PPE ML0542 ML0542 ribG ribG ML0556 ML0556 ML0577 ML0577 secA secA ML0861 ML0861 ML0926 ML0926 ML0927 ML0927 ML1055 ML1055 ML1056 ML1056 ML1106 ML1106 ML1113 ML1113 ML1114 ML1114 ML1121 ML1121 ML1122 ML1122 ML1124 ML1124 ML1159 ML1159 ML1176 ML1176 ML1180 ML1180 ML1181 ML1181 ML1182 ML1182 ML1232 ML1232 glbO glbO ML1340 ML1340 ML1418 ML1418 ndk ndk ML1497 ML1497 ML1562 ML1562 adhE2 adhE2 trxB trxB PPE-2 PPE-2 secY secY rpoC rpoC rpoB rpoB secE secE sodC sodC rpoA rpoA PPE-3 PPE-3 bfrA bfrA ahpC ahpC secA2 secA2 phoS2 phoS2 ML2114 ML2114 ML2143 ML2143 phoS3 phoS3 lpd lpd ML2465 ML2465 ML2531 ML2531 ML2532 ML2532 aac aac mce1A mce1A mce1B mce1B mce1C mce1C mce1D mce1D lprK lprK mce1F mce1F ML2647 ML2647 trxB-2 trxB-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene neighborhood
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co-expression
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ML1123Probable binding-protein dependent transport protein; Highly similar to many membrane transport proteins e.g. Mycobacterium tuberculosis putative peptide transport permease Rv1282c SW:YC82_MYCTU (Q10623) (291 aa); Fasta score E(): 0, 82.6% identity in 287 aa overlap and Escherichia coli SW:OPPC_ECOLI (P77664) (302 aa); Fasta score E(): 0, 38.8% identity in 289 aa overlap oligopeptide transport system permease protein. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membr [...] (299 aa)
ML0049Possible secreted protein; A secreted protein that might play a role in virulence. (95 aa)
ML0050Possible secreted protein; A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA. (100 aa)
ML0051Similar to PPE-family proteins from M. tuberculosis e.g. Rv3873, PPE-family protein, TR:O69738 (EMBL:AL123456) (368 aa); Fasta score E(): 6.1e-32, 46.2% identity in 288 aa overlap. Lacks the PPE motif at the N-terminus. Previously sequenced as TR:O33085 (EMBL:Y14967) (302 aa); Fasta score E(): 0, 100.0% identity in 302 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; N-terminus is similar to the N-termini of ML0539, ML1828 and ML1991. (302 aa)
sodASuperoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (207 aa)
ML0131Putative oxidoreductase; Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis. (382 aa)
ML0269Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. (336 aa)
ML0348Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. (350 aa)
ML0363Possible secreted protein; Similar to M. tuberculosis Rv3444c, esat6-family protein, TR:O06261 (EMBL:Al123456) (100 aa); Fasta score E(): 3.3e-20, 71.2% identity in 73 aa overlap and others of the esat6 family e.g. esat6 itself, 6 kDa early secretory antigenic target, SW:ESA6_MYCTU (Q57165) (94 aa); Fasta score E(): 1.5, 28.4% identity in 67 aa overlap; Belongs to the WXG100 family. (104 aa)
ML0369Hypothetical protein; Unknown function. Previously sequenced as TR:Q49877 (EMBL:U00020) (118 aa); Fasta score E(): 0, 100.0% identity in 118 aa overlap. (118 aa)
ML0411Serine-rich antigen; Similar to M. tuberculosis PPE-family proteins e.g. Rv2108, PPE-family protein, TR:P95315 (EMBL:AL123456) (243 aa); Fasta score E(): 5.8e-17, 34.4% identity in 212 aa overlap. M. leprae serine-rich antigen (25L) (45 kDa protein). Previously sequenced as SW:SRA_MYCLE (Q07297) (408 aa); Fasta score E(): 0, 100.0% identity in 408 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; Similar to ML0539, ML1182 and ML1991. (408 aa)
bcpPutative antioxidant protein; Similar to M. tuberculosis bcp, Rv2521, bacterioferritin comigratory protein, TR:O5322 (EMBL:AL123456) (157 aa); Fasta score E(): 0, 79.6% identity in 157 aa overlap. Similar to many members of the AhpC/TSA family, suggesting a protective, antioxidant role. e.g. shows similarity to Sedum lineare prxQ, peroxiredoxin Q, TR:BAA90524 (EMBL:AB037598) (186 aa); Fasta score E(): 3e-17, 40.0% identity in 155 aa overlap and weak similarity to Mus musculus tdpX1, thioredoxin peroxidase 1, SW:TDX1_MOUSE (Q61171) (343 aa); BlastP Expect 8.8. Previously sequenced as TR [...] (161 aa)
secDPutative protein-export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (597 aa)
secFPutative protein-export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (471 aa)
ML0489Putative lipoprotein; Similar to M. tuberculosis Rv2585c, hypothetical protein, SW:YP85_MYCTU (Q50636) (557 aa); Fasta score E(): 0, 78.9% identity in 546 aa overlap. Previously sequenced as SW:YP85_MYCLE (Q49646) (426 aa); Fasta score E(): 0, 98.8% identity in 332 aa overlap. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (555 aa)
PPEPPE-family protein; Similar to M. tuberculosis PPE, Rv1387, PPE-family protein, TR:P71657 (EMBL:AL123456) (539 aa); Fasta score E(): 0, 69.5% identity in 544 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; Similar to ML0411, ML1182, ML1828 and ML1991. (538 aa)
ML0542Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
ribGPutative bifunctional riboflavin-specific deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (339 aa)
ML0556Putative integral membrane drug transport protein; In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation. May be an efflux transporter and involved in maintaining correct cell wall permeability. Probably required with LprG for normal surface localization of lipoarabinomannan (LAM). Belongs to the major facilitator superfamily. (509 aa)
ML0577Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. (77 aa)
secAPutative preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (940 aa)
ML0861Putative dihydrolipoamide acyltransferase; Similar to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB or Rv2215 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 0, 81.8% id in 555 aa. Similar to Streptomyces seoulensis dihydrolipoamide acetyltransferase pdhB TR:Q9Z6I4 (EMBL:AF047034) (612 aa) fasta scores: E(): 0, 51.6% id in 614 aa and to many succinyltransferases e.g. Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB SW:ODO2_ECOLI (P07016) [...] (530 aa)
ML0926Hypothetical protein; Weakly similar, in parts, to Mycobacterium tuberculosis SW:Y940_MYCTU (P71569) (288 aa); Fasta score E(): 0.0071, 30.4% identity in 112 aa overlap. (122 aa)
ML0927Hypothetical protein. (102 aa)
ML1055Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49945 (EMBL:U15180) (100 aa); Fasta score E(): 0, 100.0% identity in 100 aa overlap. Also similar to another Mycobacterium leprae hypothetical protein TR:Q9S382 (EMBL:AL049191) (94 aa); Fasta score E(): 0, 100.0% identity in 94 aa overlap and several proteins of undefined function from Mycobacterium tuberculosis e.g. TR:O05299 (EMBL:Z93777) (98 aa); Fasta score E(): 1.7e-20, 58.3% identity in 96 aa overlap; Belongs to the WXG100 family. (100 aa)
ML1056Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49946 (EMBL:U15180) (95 aa); Fasta score E(): 0, 100.0% identity in 95 aa overlap. Also highly similar to several proteins of undefined function from Mycobacterium tuberculosis e.g. Rv1793 TR:O53942 (EMBL:AL022021) (94 aa); Fasta score E(): 4.3e-23, 65.2% identity in 92 aa overlap; Belongs to the WXG100 family. (95 aa)
ML1106Hypothetical protein; Unknown function. (113 aa)
ML1113Probable ABC transporter, ATP-binding component; Highly similar to many proposed ABC transporter proteins including: Mycobacterium tuberculosis Rv1272c SW:YC72_MYCTU (Q11047) (631 aa); Fasta score E(): 0, 75.4% identity in 623 aa overlap and Bacillus subtilis hypothetical ABC transporter ATP-binding protein SW:YFIC_BACSU (P54719) (604 aa); Fasta score E(): 0, 43.2% identity in 532 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region. Contains Pfam match to entry PF00005 ABC_tran, ABC [...] (629 aa)
ML1114Probable ABC transporter protein, ATP-binding component; Highly similar to many proposed ABC transporter proteins including: Mycobacterium tuberculosis Rv1273c SW:YC73_MYCTU (Q11046) (582 aa); Fasta score E(): 0, 78.4% identity in 583 aa overlap and Bacillus subtilis hypothetical ABC transporter ATP-binding protein SW:YFIB_BACSU (P54718) (573 aa); Fasta score E(): 0, 34.4% identity in 569 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region.. Contains Pfam match to entry PF00005 ABC_ [...] (584 aa)
ML1121Probable extracellular solute-binding dependent transport lipoprotein; Similar to several including: Mycobacterium tuberculosis extracellular solute-binding Rv1280c SW:YC80_MYCTU (Q11041) (591 aa); Fasta score E(): 0, 80.3% identity in 548 aa overlap and Escherichia coli putative binding protein YddS precursor SW:YDDS_ECOLI (P76128) (516 aa); Fasta score E(): 2.3e-10, 22.5% identity in 480 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF00496 SBP_bac_5, Bact [...] (557 aa)
ML1122Probable ABC transport protein, ATP-binding component; Highly similar to many putative ABC transport proteins e.g. Escherichia coli SW:YLIA_ECOLI (P75796) (269 aa); BlastP Expect 4.0e-28 Mycobacterium tuberculosis Rv1281c SW:YC81_MYCTU (Q11040 (269 aa); BlastP Expect 4.0e-28. Note, that the N- and C-termini of this CDS are possible duplicates. Contains 2 Pfam matches to entry PF00005 ABC_tran, ABC transporter. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop). Contains 2 x PS00211 ABC transporters family signature. (609 aa)
ML1124Probable binding-protein dependent transport protein; Highly similar to many membrane transport proteins e.g. Mycobacterium tuberculosis putative peptide transport permease protein Rv1283c SW:YC83_MYCTU (Q10611) (325 aa); Fasta score E(): 0, 83.4% identity in 325 aa overlap and Bacillus subtilis oligopeptide transport system permease SW:APPB_BACSU (P42062) (317 aa); Fasta score E(): 4.5e-27, 34.1% identity in 328 aa overlap. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein [...] (325 aa)
ML1159Conserved hypothetical protein; Previously sequenced Mycobacterium leprae TR:Q49716 (EMBL:U00014) (255 aa); Fasta score E(): 0, 100.0% identity in 217 aa overlap. Highly similar to Mycobacterium tuberculosis Rv1324 SW:YD24_MYCTU (Q10636) (304 aa); Fasta score E(): 0, 72.4% identity in 301 aa overlap. Also weakly similar in parts to several putative thioredoxins e.g. Alicyclobacillus acidocaldarius SW:THIO_ALIAC (P80579) (105 aa); Fasta score E(): 0.00045, 27.1% identity in 107 aa overlap. (301 aa)
ML1176Possible conserved membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD42_MYCLE (P54133) (119 aa); Fasta score E(): 0, 100.0% identity in 119 aa overlap. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv1342c TR:YD42_MYCTU and Streptomyces coelicolor TR:Q9X948 (EMBL:AJ237976) (109 aa); Fasta score E(): 7.7e-11, 36.5% identity in 96 aa overlap. Contains possible membrane spanning hydrophobic domains. (119 aa)
ML1180Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49946 (EMBL:U15180) (95 aa); Fasta score E(): 0, 100.0% identity in 95 aa overlap. Also similar to many Mycobacterium tuberculosis proteins with undefined function e.g. RV1793 TR:O53942 (EMBL:AL022021) (94 aa); Fasta score E(): 4.3e-23, 65.2% identity in 92 aa overlap. (95 aa)
ML1181Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49945 (EMBL:U15180) (100 aa); Fasta score E(): 0, 100.0% identity in 100 aa overlap. Also similar to many Mycobacterium tuberculosis proteins with undefined function e.g. RV1197 TR:O05299 (EMBL:Z93777) (98 aa); Fasta score E(): 1.7e-20, 58.3% identity in 96 aa overlap. (100 aa)
ML1182PPE-family protein; Identical to the previously sequenced Mycobacterium leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 aa); Fasta score E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to many members of the Mycobacterium tuberculosis PPE-family of proteins e.g. Rv2892c SW:YS92_MYCTU (Q10813) (408 aa); Fasta score E(): 1.2e-25, 34.0% identity in 429 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family. (421 aa)
ML1232Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49633 (EMBL:U00010) (391 aa); Fasta score E(): 0, 100.0% identity in 358 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1184c TR:O50440 (EMBL:AL010186) (359 aa); Fasta score E(): 0, 62.7% identity in 338 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (358 aa)
glbOHemoglobin-like, oxygen carrier; Highly similar to putative globins from Mycobacterium tuberculosis RV2470 TR:O53197 (EMBL:AL021246) (128 aa); Fasta score E(): 0, 88.7% identity in 124 aa overlap and Mycobacterium bovis TR:AAF36597 (EMBL:AF213450) (128 aa); Fasta score E(): 0, 88.7% identity in 124 aa overlap. (128 aa)
ML1340Possible reductase; Similar to several including: the C-terminal reductase domains of several riboflavin biosynthetic proteins e.g. Escherichia coli RibD SW:RIBD_ECOLI (X64395) (367 aa); Fasta score E(): 0.0028, 23.8% identity in 227 aa overlap. Also similar to Mycobacterium tuberculosis RV2671 TR:P71968 (EMBL:Z80225) (258 aa); Fasta score E(): 0, 72.9% identity in 251 aa overlap. Contains Pfam match to entry PF01872 RibD_C, RibD C-terminal domain. (268 aa)
ML1418Conserved hypothetical protein; Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis TR:P71990 (EMBL:Z81360) (182 aa); Fasta score E(): 0, 86.3% identity in 182 aa overlap and Synechocystis sp. TR:P73178 (EMBL:D90904) (194 aa); Fasta score E(): 0, 52.5% identity in 179 aa overlap. (182 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
ML1497Possible secreted protein; Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV1166 TR:O50422 (EMBL:AL01018) (635 aa); Fasta score E(): 0, 80.4% identity in 632 aa overlap. Contains a possible N-terminal signal sequence. (617 aa)
ML1562Highly similar to several transmembrane transport proteins including: Streptomyces lipmanii SW:PUR8_STRLP (P42670) (503 aa); Fasta score E(): 0, 33.3% identity in 481 aa overlap and Mycobacterium tuberculosis TR:O05813 (EMBL:Z95207) (530 aa); Fasta score E(): 0, 86.5% identity in 535 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter. (534 aa)
adhE2Putative alcohol dehydrogenase (Zn dependent); Similar to M. tuberculosis adhE2 Rv2259 TR:O53533 (EMBL:AL021925) (361 aa); Fasta score E(): 0, 88.9% identity in 361 aa overlap, and to other alcohol dehydrogenases e.g. Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase SW:FADH_AMYME (P80094) (360 aa); Fasta score E(): 0, 80.4% identity in 358 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; S [...] (361 aa)
trxBThioredoxin; Similar to M. tuberculosis thioredoxin trxB Rv1471 TR:O53162 (EMBL:AL021184) (123 aa); Fasta score E(): 2.4e-25, 65.4% identity in 107 aa overlap, and M. tuberculosis thioredoxin trxA Rv1470 TR:O53161 (EMBL:AL021184) (124 aa); Fasta score E(): 1.6e-17, 47.0% identity in 117 aa overlap. Also similar to Escherichia coli thioredoxin 2 SW:THI2_ECOLI (P33636) (139 aa); Fasta score E(): 1.7e-07, 37.1% identity in 89 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin; Similar to and ML2703. (130 aa)
PPE-2PPE-family protein; Similar to Mycobacterium tuberculosis PPE-family proteins e.g. Rv0256c or MTV034.22C TR:O53678 (EMBL:AL021929) (556 aa) fasta scores: E(): 0, 63.5% id in 564 aa. Previously sequenced as TR:O33009 (EMBL:Z98756). Contains Pfam match to entry PF00823 PPE, PPE family. (572 aa)
secYSecY subunit of preprotein translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (438 aa)
rpoC[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa)
rpoB[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)
secESecE preprotein translocase; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (146 aa)
sodCSuperoxide dismutase precursor (Cu-Zn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity). (240 aa)
rpoA[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)
PPE-3PPE-family protein; Similar to M. tuberculosis PPE-family protein Rv0096 SW:Y096_MYCTU (Q10892) (463 aa); Fasta score E(): 0, 58.6% identity in 466 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; Similar to ML1828 and ML0539. (468 aa)
bfrABacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex (By similarity). Probably plays a crucial role in the intracellular existence of this organism by functioning as a temporary depository for iron in iron deprivation; Belongs to the bacterioferritin family. (159 aa)
ahpCAlkyl hydroperoxide reductase; Similar to Mycobacterium avium alkyl hydroperoxidase C TR:Q57413 (EMBL:U18263) fasta scores: E(): 0, 86.2% in 195 aa, and to Streptomyces viridosporus alkyl hydroperoxide reductase TR:Q9X5V0 (EMBL:AF127576) fasta scores: E(): 0, 58.7% in 189 aa. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family. (195 aa)
secA2SecA, preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (778 aa)
phoS2PstS component of phosphate uptake; Part of the ABC transporter complex PstSACB involved in phosphate import. (369 aa)
ML2114Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 6.4 kda protein TR:O05901 (EMBL:Z95210) fasta scores: E(): 1.8e-07, 61.9% in 42 aa, and to Streptomyces coelicolor hypothetical 9.9 kda protein TR:O69965 (EMBL:AL022268) fasta scores: E(): 0.038, 41.3% in 46 aa. (56 aa)
ML2143Possible membrane protein; Similar to Mycobacterium tuberculosis hypothetical 57.9 kda protein rv0876c SW:Y876_MYCTU (Q10564) fasta scores: E(): 0, 81.2% in 568 aa, and to Streptomyces coelicolor putative integral membrane protein TR:CAB93403 (EMBL:AL357524) fasta scores: E(): 5.3e-16, 38.8% in 448 aa. Contains possible membrane spanning hydrophobic domains. (579 aa)
phoS3Phosphate-binding protein 3 precursor; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (429 aa)
lpdDihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes (By similarity); Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (467 aa)
ML2465Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 21.3 kda protein Rv0464c TR:O53749 (EMBL:AL021933) fasta scores: E(): 0, 67.4% id in 187 aa. (188 aa)
ML2531Possible cell surface protein; Similar to Mycobacterium tuberculosis 10 kda antigenic protein RV0288 SW:CFP7_MYCTU (O53693) fasta scores: E(): 6.1e-29, 70.5% id in 95 aa. (96 aa)
ML2532PE-family protein; Similar to Mycobacterium tuberculosis PE-family protein RV3020C TR:O53267 (EMBL:AL021287) fasta scores: E(): 5.5e-26, 73.7% id in 95 aa; Belongs to the WXG100 family. (98 aa)
aacHighly similar to several mycobacterial aminoglycoside-resistance determinants e.g. Mycobacterium tuberculosis aminoglycoside 2'-n-acetyltransferase Aac OR RV0262C SW:AAC2_MYCTU (P95219; P72033) fasta scores: E(): 0, 78.7% id in 178 aa. (182 aa)
mce1APutative cell invasion protein; Highly similar to Mycobacterium tuberculosis Mce proteins associated with entry and survival inside macrophage e.g. RV0169 ORMTCI28.08 TR:P72013 (EMBL:Z97050) fasta scores: E(): 0, 67.5% id in 456 aa.Orthologue of M. tuberculosis Mce1A (Rv0169). Contains a possible N-terminal signal sequence. (441 aa)
mce1BPutative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0170 TR:O07414 (EMBL:Z97050) fasta scores: E(): 0, 75.1% id in 346 aa. Orthologue of M. tuberculosis mce1B (Rv0170). Contains a possible N-terminal signal sequence. (346 aa)
mce1CPutative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g.RV0171 TR:O07415 (EMBL:Z97050) fasta scores: E(): 0, 72.4% id in 525 aa. Orthologue of M. tuberculosis Mce1C (Rv0171). Contains a possible N-terminal signal sequence. (519 aa)
mce1DPutative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0172 TR:O07416 (EMBL:Z97050) fasta scores: E(): 0, 78.1% id in 534 aa. Orthologue of M. tuberculosis Mce1D (Rv0172). Contains a possible N-terminal signal sequence. (531 aa)
lprKPutative lipoprotein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0173 TR:O07417 (EMBL:Z97050) fasta scores: E(): 0, 76.3% id in 389 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Orthologue of M. tuberculosis lprK (mce1E, Rv0173). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (392 aa)
mce1FPutative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0174 TR:O07418 (EMBL:Z97050) fasta scores: E(): 0, 76.5% id in 515 aa. Orthologue of M. tuberculosis Mce1F (Rv0174). Contains a possible N-terminal signal sequence. (516 aa)
ML2647Putative peptide methionine sulfoxide; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (177 aa)
trxB-2Bifunctional thioredoxin reductase/thioredoxin; EC_number=EC 1.6.4.5; Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site. (458 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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