STRINGSTRING
fadD32 fadD32 fadD29 fadD29 fadD22 fadD22 fadD28 fadD28 ML0243 ML0243 fadD9 fadD9 ML0887 ML0887 xclC xclC ML1234 ML1234 ML1346 ML1346 fadD10 fadD10 nrp nrp menE menE fadD26 fadD26 fadD2 fadD2 ML2661 ML2661
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadD32Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv3801c, fadD32, putative acyl-CoA synthase, TR:O53580 (EMBL:AL123456) (637 aa); Fasta score E(): 0, 93.2% identity in 632 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 36.8% identity in 581 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.4% identity in 605 aa overlap. Contains Pfam match to entry PF005 [...] (635 aa)
fadD29Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] (680 aa)
fadD22Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. (707 aa)
fadD28Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% identity in 580 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 35.8% identity in 590 aa overlap. Contains Pfam match to entry PF0050 [...] (579 aa)
ML0243Similar to several putative acyl-CoA synthases from M.tuberculosis e.g. pks16, Rv1013, possible polyketide synthase, TR:O05598 (EMBL:AL123456) (544 aa); Fasta score E(): 0, 82.2% identity in 544 aa overlap. Similar to domains of polyketide synthases e.g. Bacillus subtilis mycA, mycosubtilin synthetase, TR:Q9R9J1 (EMBL:AF184956) (3971 aa); Fasta score E(): 0, 33.7% identity in 404 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature; Similar to ML0887, ML0100, ML0132, ML0138, ML1051, ML1234, ML1994, ML23 [...] (544 aa)
fadD9Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...] (1188 aa)
ML0887Putative long-chain-fatty-acid-CoA ligase; The C-terminus of the predicted product of this CDS is identical to the previously sequenced Mycobacterium leprae putative long-chain- fatty-acid-CoA ligase TR:O69578 (EMBL:AL022602) (351 aa); Fasta score E(): 0, 100.0% identity in 351 aa overlap(EMBL:AL022602). Also similar to Mycobacterium tuberculosis putative long-chain-fatty-acid-CoA ligase, fadD15, TR:O53521 (EMBL:AL021957) (600 aa); Fasta score E(): 0, 80.3% identity in 600 aa overlap(EMBL:AL021957) and Haemophilus influenzae putative long-chain-fatty-acid-CoA ligase (EC 6.2.1.3) SW:LCF [...] (600 aa)
xclCacyl-CoA synthase; Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (476 aa)
ML1234Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% identity in 579 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0100, ML0132, ML0138, ML0243 and ML2358; Belongs to the ATP-dependent AMP-binding enzyme family. (579 aa)
ML1346Similar to many Prokaryotic and Eukaryotic long-chain acyl-CoA synthetases including: Mus musculus SW:VLCS_MOUSE (O35488) (620 aa); Fasta score E(): 1.5e-20, 24.7% identity in 570 aa overlap and Chromatium vinosum poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) SW:PHBC_CHRVI (P45370) (355 aa); Fasta score E(): 4.7e-17, 28.2% identity in 348 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein RV1683 TR:O33185 (EMBL:Z98268) (999 aa); Fasta score E(): 0, 85.6% identity in 1002 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (1002 aa)
fadD10acyl-CoA synthase; Similar to Mycobacterium tuberculosis putative acyl-CoA synthases e.g. Rv0099 or MTCY251.18 TR:Q10878 (EMBL:Z74410) (540 aa) fasta scores: E(): 0, 74.6% id in 531 aa. Previously sequenced as TR:Q50176 (EMBL:Z46257). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (532 aa)
nrpProbable peptide synthase; Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa); Fasta score E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa); Fasta score E(): 5.6e-20, 31.2% identity in 382 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML1051 and ML0243. (1401 aa)
menEO-succinylbenzoic acid-CoA ligase; Similar to Mycobacterium tuberculosis MenE or RV0542C or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% id in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% id in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (368 aa)
fadD26Probable acyl-CoA synthase; Similar to Mycobacterium tuberculosis acyl-CoA synthase Rv1185c TR:O50441 (EMBL:AL010186) (578 aa) fasta scores: E(): 0, 56.9% id in 580 aa, and to Myxococcus xanthus saframycin synthetase B TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 0, 36.5% id in 578 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0132, ML1234, ML0138 and ML0100. (583 aa)
fadD2acyl-CoA synthase; Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% id in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein RV0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
ML2661acyl-CoA synthase; Similar to many Prokaryotic and Eukaryotic acyl-CoA synthases including: Mycobacterium tuberculosis fadd7 protein TR:O07169 (EMBL:Z96071) fasta scores: E(): 0, 71.3% in 520 aa, and to Saccharomyces cerevisiae peroxisomal-coenzyme a synthetase SW:FAT2_YEAST (P38137) fasta scores: E(): 0, 35.6% in 526 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.