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fadD29 fadD29 fbpA fbpA echA1 echA1 fadD28 fadD28 fadE25 fadE25 xclC xclC ML1241 ML1241 ML1244 ML1244 fadD10 fadD10 fadD26 fadD26 fadB2 fadB2 ML2498 ML2498 fadD2 fadD2 fadE5 fadE5 fadA2 fadA2 ML2661 ML2661
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadD29Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] (680 aa)
fbpAAntigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...] (330 aa)
echA1Similar to M. tuberculosis Rv3774, putative enoyl-CoA hydratase, TR:P75019 (EMBL:AL123456) (274 aa); Fasta score E(): 0, 88.3% identity in 274 aa overlap. Similar to many e.g. Rattus norvegicus ech1, delta3,5-delta2,4-dienoyl-coa isomerase precursor, SW:ECH1_RAT (Q62651) (327 aa); Fasta score E(): 3.5e-31, 38.8% identity in 276 aa overlap and bacterial putative enoyl-CoA hydratases. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1241, ML1724, ML2118 and ML2402. (278 aa)
fadD28Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% identity in 580 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 35.8% identity in 590 aa overlap. Contains Pfam match to entry PF0050 [...] (579 aa)
fadE25Putative acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis RV3274C OR MTCY71.14C, putative acyl-CoA dehydrogenase, TR:P96879 (EMBL:Z92771) fasta scores: E(): 0, 92.0% id in 389 aa, and to Streptomyces lividans fatty acid acyl-CoA dehydrogenase fadE TR:Q9RIQ5 (EMBL:AJ250495) fasta scores: E(): 0, 67.6% id in 383 aa. Previously sequenced as SW:ACD_MYCLE (P46703). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1; Similar to ML0660, ML0661 and show [...] (389 aa)
xclCacyl-CoA synthase; Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (476 aa)
ML1241Possible enoyl-CoA hydratase/isomerase; Could possibly oxidize fatty acids using specific components. (294 aa)
ML1244Conserved membrane protein; Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa overlap. Contains possible membrane spanning hydrophobic domains; Belongs to the long-chain O-acyltransferase family. (491 aa)
fadD10acyl-CoA synthase; Similar to Mycobacterium tuberculosis putative acyl-CoA synthases e.g. Rv0099 or MTCY251.18 TR:Q10878 (EMBL:Z74410) (540 aa) fasta scores: E(): 0, 74.6% id in 531 aa. Previously sequenced as TR:Q50176 (EMBL:Z46257). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (532 aa)
fadD26Probable acyl-CoA synthase; Similar to Mycobacterium tuberculosis acyl-CoA synthase Rv1185c TR:O50441 (EMBL:AL010186) (578 aa) fasta scores: E(): 0, 56.9% id in 580 aa, and to Myxococcus xanthus saframycin synthetase B TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 0, 36.5% id in 578 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0132, ML1234, ML0138 and ML0100. (583 aa)
fadB23-hydroxyacyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative 3-hydroxyacyl-CoA dehydrogenase Rv0468 TR:O53753 (EMBL:AL021933) fasta scores: E(): 0, 89.5% id in 287 aa, and to Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydrogenase SW:HBD_CLOAB (P52041) fasta scores: E(): 0, 43.3% id in 282 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. (287 aa)
ML2498Possible enoyl-CoA hydratase; Similar to several proteins belonging to the enoyl-CoA hydratase/isomerase family e.g. Arabidopsis thaliana carnitine racemase homolog TR:O23300 (EMBL:Z97336) fasta scores: E(): 1.7e-17, 36.0% id in 203 aa and Escherichia coli carnitine racemase CAID SW:CAID_ECOLI (P31551; P75623) fasta scores: E(): 2.9e-08, 29.0% id in 214 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (219 aa)
fadD2acyl-CoA synthase; Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% id in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein RV0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
fadE5acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative acyl-CoA dehydrogenase RV0244C TR:O53666 (EMBL:AL021929) fasta scores: E(): 0, 89.4% id in 611 aa. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (611 aa)
fadA2acetyl-CoA C-acetyltransferase; Similar to many Prokaryotic and Eukaryotic thiolases including: Escherichia coli probable 3-ketoacyl-coa thiolase YFCY SW:YFCY_ECOLI (P76503) fasta scores: E(): 0, 36.9% id in 434 aa and to Rattus norvegicus trifunctonal enzyme beta subunit, mitochondrial precursor SW:ECHB_RAT (Q60587) fasta scores: E(): 0, 37.2% id in 462 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (457 aa)
ML2661acyl-CoA synthase; Similar to many Prokaryotic and Eukaryotic acyl-CoA synthases including: Mycobacterium tuberculosis fadd7 protein TR:O07169 (EMBL:Z96071) fasta scores: E(): 0, 71.3% in 520 aa, and to Saccharomyces cerevisiae peroxisomal-coenzyme a synthetase SW:FAT2_YEAST (P38137) fasta scores: E(): 0, 35.6% in 526 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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