9 items (Mycobacterium leprae) - STRING interaction network

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	ML0049	Possible secreted protein; A secreted protein that might play a role in virulence. (95 aa)
	trxB-2	Bifunctional thioredoxin reductase/thioredoxin; EC_number=EC 1.6.4.5; Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site. (458 aa)
	dnaK	70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. (620 aa)
	fbpB	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...] (327 aa)
	trxB	Thioredoxin; Similar to M. tuberculosis thioredoxin trxB Rv1471 TR:O53162 (EMBL:AL021184) (123 aa); Fasta score E(): 2.4e-25, 65.4% identity in 107 aa overlap, and M. tuberculosis thioredoxin trxA Rv1470 TR:O53161 (EMBL:AL021184) (124 aa); Fasta score E(): 1.6e-17, 47.0% identity in 117 aa overlap. Also similar to Escherichia coli thioredoxin 2 SW:THI2_ECOLI (P33636) (139 aa); Fasta score E(): 1.7e-07, 37.1% identity in 89 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin; Similar to and ML2703. (130 aa)
	groES	10 kD chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (100 aa)
	fbpC	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars. (301 aa)
	fbpA	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...] (330 aa)
	ML0050	Possible secreted protein; A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA. (100 aa)

Your Current Organism:

Mycobacterium leprae

NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ML0049	ML0050	gene:17573861	gene:17573862	Possible secreted protein; A secreted protein that might play a role in virulence.	Possible secreted protein; A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA.	0.999
ML0049	fbpA	gene:17573861	gene:17573909	Possible secreted protein; A secreted protein that might play a role in virulence.	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.682
ML0049	fbpB	gene:17573861	gene:17575880	Possible secreted protein; A secreted protein that might play a role in virulence.	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.792
ML0049	fbpC	gene:17573861	gene:17573910	Possible secreted protein; A secreted protein that might play a role in virulence.	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	0.406
ML0049	groES	gene:17573861	gene:17574199	Possible secreted protein; A secreted protein that might play a role in virulence.	10 kD chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.493
ML0050	ML0049	gene:17573862	gene:17573861	Possible secreted protein; A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA.	Possible secreted protein; A secreted protein that might play a role in virulence.	0.999
dnaK	groES	gene:17576360	gene:17574199	70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family.	10 kD chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.980
dnaK	trxB	gene:17576360	gene:17575665	70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Thioredoxin; Similar to M. tuberculosis thioredoxin trxB Rv1471 TR:O53162 (EMBL:AL021184) (123 aa); Fasta score E(): 2.4e-25, 65.4% identity in 107 aa overlap, and M. tuberculosis thioredoxin trxA Rv1470 TR:O53161 (EMBL:AL021184) (124 aa); Fasta score E(): 1.6e-17, 47.0% identity in 117 aa overlap. Also similar to Escherichia coli thioredoxin 2 SW:THI2_ECOLI (P33636) (139 aa); Fasta score E(): 1.7e-07, 37.1% identity in 89 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin; Similar to and ML2703.	0.441
dnaK	trxB-2	gene:17576360	gene:17576569	70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Bifunctional thioredoxin reductase/thioredoxin; EC_number=EC 1.6.4.5; Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site.	0.525
fbpA	ML0049	gene:17573909	gene:17573861	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Possible secreted protein; A secreted protein that might play a role in virulence.	0.682
fbpA	fbpB	gene:17573909	gene:17575880	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.902
fbpA	fbpC	gene:17573909	gene:17573910	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	0.571
fbpB	ML0049	gene:17575880	gene:17573861	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Possible secreted protein; A secreted protein that might play a role in virulence.	0.792
fbpB	fbpA	gene:17575880	gene:17573909	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.902
fbpB	fbpC	gene:17575880	gene:17573910	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	0.580
fbpC	ML0049	gene:17573910	gene:17573861	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	Possible secreted protein; A secreted protein that might play a role in virulence.	0.406
fbpC	fbpA	gene:17573910	gene:17573909	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.571
fbpC	fbpB	gene:17573910	gene:17575880	Antigen 85C, mycolyltransferase; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.	Antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]	0.580
groES	ML0049	gene:17574199	gene:17573861	10 kD chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	Possible secreted protein; A secreted protein that might play a role in virulence.	0.493
groES	dnaK	gene:17574199	gene:17576360	10 kD chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.980