node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1328 | ML1329 | gene:17575162 | gene:17575163 | Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | 0.969 |
ML1328 | ML1330 | gene:17575162 | gene:17575164 | Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | 0.966 |
ML1329 | ML1328 | gene:17575163 | gene:17575162 | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.969 |
ML1329 | ML1330 | gene:17575163 | gene:17575164 | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | 0.999 |
ML1329 | rpoB | gene:17575163 | gene:17575739 | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.572 |
ML1330 | ML1328 | gene:17575164 | gene:17575162 | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.966 |
ML1330 | ML1329 | gene:17575164 | gene:17575163 | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | 0.999 |
ML1330 | rpoB | gene:17575164 | gene:17575739 | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.725 |
folP | gyrA | gene:17574041 | gene:17573815 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.780 |
folP | rpoB | gene:17574041 | gene:17575739 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.770 |
gyrA | folP | gene:17573815 | gene:17574041 | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.780 |
gyrA | rpoB | gene:17573815 | gene:17575739 | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.921 |
rpoB | ML1329 | gene:17575739 | gene:17575163 | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. | 0.572 |
rpoB | ML1330 | gene:17575739 | gene:17575164 | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. | 0.725 |
rpoB | folP | gene:17575739 | gene:17574041 | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.770 |
rpoB | gyrA | gene:17575739 | gene:17573815 | [beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.921 |