STRINGSTRING
lplA lplA rpoC rpoC rpoB rpoB epsG-5 epsG-5 galU-2 galU-2 cps-5 cps-5 epsG-4 epsG-4 cps-4 cps-4 epsG-3 epsG-3 cps-3 cps-3 epsG-2 epsG-2 spoU-3 spoU-3 prs prs dam dam dcm-2 dcm-2 MSC_0945 MSC_0945 ptsK ptsK lgt(-rpoD) lgt(-rpoD) MSC_0937 MSC_0937 gidB gidB pgsA pgsA glyA glyA upp upp arcC-3 arcC-3 glk-2 glk-2 ptsG-4 ptsG-4 arcC-2 arcC-2 glk glk ptsG-3 ptsG-3 hpt-2 hpt-2 frvB-2 frvB-2 frvA frvA suk suk pnp pnp fruB fruB frvB frvB deoA deoA patB-2 patB-2 patB patB MSC_0780 MSC_0780 cps-2 cps-2 gatC gatC gatA gatA pts-4 pts-4 dhaK1 dhaK1 rplB rplB adk adk rpoA rpoA arcB arcB arcC arcC pncB pncB dnaE dnaE polA-2 polA-2 pgk pgk MSC_0665 MSC_0665 MSC_0664 MSC_0664 fruK fruK pts-3 pts-3 spoU-2 spoU-2 pyrH pyrH rsmH rsmH acpS acpS plsC plsC rsmI rsmI udk udk dinP dinP lplA-2 lplA-2 spoU spoU gid gid metK metK MSC_0481 MSC_0481 plsX plsX relA relA apt apt MSC_0467 MSC_0467 dnaG dnaG fmt fmt trmU trmU MSC_0444 MSC_0444 nadD nadD trmD trmD rlmH rlmH cmk cmk MSC_0395 MSC_0395 pts-2 pts-2 MSC_0388 MSC_0388 gidA gidA tkt tkt cdsA cdsA polC polC ribF ribF pkn pkn MSC_0304 MSC_0304 nadK nadK MSC_0287 MSC_0287 thiI thiI MSC_0277 MSC_0277 dhaK2 dhaK2 crr crr ptsI ptsI kdtB kdtB ackA ackA pta pta pdhC pdhC pyk pyk pfk pfk glpK glpK hpt hpt pts pts MSC_0219 MSC_0219 gmk gmk sun sun dcm dcm mod mod MSC_0188 MSC_0188 MSC_0186 MSC_0186 trmB trmB ptsG-2 ptsG-2 cls cls hemK hemK tdk tdk MSC_0133 MSC_0133 nagE nagE plsY plsY galU galU cps cps epsG epsG ribC/ribF ribC/ribF hlyA hlyA coaE coaE polA polA gcp gcp ptsG ptsG dnaX dnaX tmk tmk holB holB MSC_0044 MSC_0044 EIIBC-mtl EIIBC-mtl EIIA-mtl EIIA-mtl ksgA ksgA dnaN dnaN
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lplALipoate protein ligase. (334 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1255 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1291 aa)
epsG-5Glycosyltransferase. (457 aa)
galU-2UTP-glucose-1-phosphate uridylyltransferase. (290 aa)
cps-5Glycosyltransferase. (304 aa)
epsG-4Glycosyltransferase. (382 aa)
cps-4Glycosyltransferase. (271 aa)
epsG-3Glycosyltransferase. (382 aa)
cps-3Glycosyltransferase. (266 aa)
epsG-2Glycosyltransferase. (382 aa)
spoU-3rRNA Methylase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (244 aa)
prsRibose-phosphate pyrophosphokinase. (357 aa)
damAdenine-specific DNA-methyltransferase; Truncated. (247 aa)
dcm-2Cytosine-specific DNA-methyltransferase; Truncated; deleted EC_number 2.1.1.73; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (116 aa)
MSC_0945Conserved hypothetical protein. (319 aa)
ptsKHpr serine kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon source [...] (313 aa)
lgt(-rpoD)Prolipoprotein diacylglyceryl transferase and tran; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. (526 aa)
MSC_0937Hypothetical transmembrane protein. (170 aa)
gidBGlucose-inhibited division protein B; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (137 aa)
pgsACDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (206 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (227 aa)
arcC-3Carbamate kinase; Belongs to the carbamate kinase family. (301 aa)
glk-2GLUCOKINASE; Truncated. (242 aa)
ptsG-4PTS system, glucose-specific, IIBC component. (676 aa)
arcC-2Carbamate kinase; Belongs to the carbamate kinase family. (310 aa)
glkGLUCOKINASE. (261 aa)
ptsG-3PTS system, glucose-specific IIBC component. (676 aa)
hpt-2Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
frvB-2PTS system, fructose-specific IIBC component. (613 aa)
frvAPTS system, fructose-specific IIA component. (152 aa)
sukSugar kinase, ROK family. (297 aa)
pnpPurine nucleoside phosphorylase. (217 aa)
fruB1-PHOSPHOFRUCTOKINASE; Belongs to the carbohydrate kinase PfkB family. (311 aa)
frvBPTS system, fructose-specific IIBC component. (678 aa)
deoAThymidine phosphorylase. (437 aa)
patB-2Aminotransferase (PLP-dependent). (396 aa)
patBAminotransferase (PLP-dependent). (396 aa)
MSC_0780Putative C5 methylase (MAV1virus-like). (284 aa)
cps-2Glycosyltransferase. (318 aa)
gatCGlutamyl-tRNA (Gln) amidotransferase, subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (98 aa)
gatAglutamyl-tRNA (Gln) amidotransferase subunit A; Belongs to the amidase family. (485 aa)
pts-4PTS system, trehalose-specific IIBC component. (535 aa)
dhaK1Glycerone kinase. (332 aa)
rplB50S RIBOSOMAL PROTEIN L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (282 aa)
adkADENYLATE KINASE; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (213 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (317 aa)
arcBOrnithine carbamoyltransferase; Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. (365 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (310 aa)
pncBProbable nicotinic phosphoribosyltransferase; Belongs to the NAPRTase family. (362 aa)
dnaEDNA polymerase III alpha chain. (987 aa)
polA-2DNA POLYMERASE I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (911 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (404 aa)
MSC_0665Hypothetical protein. (407 aa)
MSC_0664Conserved hypothetical protein. (226 aa)
fruK1-phosphofructokinase; Truncated. (124 aa)
pts-3PTS system, sucrose-specific IIBC component. (628 aa)
spoU-2rRNA Methylase (Spou-family); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (181 aa)
pyrHUridylate kinase; Truncated. (172 aa)
rsmHMraW methylase family protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (308 aa)
acpSHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (110 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase. (315 aa)
rsmITetrapyrrole methylas family protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (295 aa)
udkUridine kinase; Belongs to the uridine kinase family. (205 aa)
dinPDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (402 aa)
lplA-2Lipoate-protein ligase A. (345 aa)
spoUrRNA methylase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (255 aa)
gidGlucose inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (438 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa)
MSC_0481PREDICTED KINASE RELATED TO HYDROXYACETONE KINASE. (547 aa)
plsXFatty acid/phospholipid synthesis PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (334 aa)
relAGTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (750 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
MSC_0467Conserved hypothetical protein. (225 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (612 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (317 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (375 aa)
MSC_0444Deoxynucleoside kinase. (214 aa)
nadDProbable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (367 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (240 aa)
rlmHCONSERVED HYPOTHETICAL PROTEIN; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa)
cmkCytidylate kinase. (222 aa)
MSC_0395Conserved hypothetical transmembrane protein. (602 aa)
pts-2PTS system, IIA component. (149 aa)
MSC_0388Deoxyguanosine kinase. (205 aa)
gidAGlucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (424 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (666 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (341 aa)
polCDNA polymerase III alpha chain; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1482 aa)
ribFRiboflavin kinase; Truncated. (184 aa)
pknSerine/threonine protein kinase. (371 aa)
MSC_0304CONSERVED HYPOTHETICAL PROTEIN. (222 aa)
nadKHYPOTHETICAL PROTEIN; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa)
MSC_0287Conserved hypothetical transmembrane protein. (629 aa)
thiIThiamin biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (395 aa)
MSC_0277CONSERVED HYPOTHETICAL PROTEIN. (138 aa)
dhaK2Glycerone kinase. (208 aa)
crrPTS SYSTEM, GLUCOSE-SPECIFIC IIA COMPONENT. (154 aa)
ptsIPHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (573 aa)
kdtBPANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (140 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
ptaPhosphate acetyltransferase. (322 aa)
pdhCDihydrolipoamide S-acetyltransferase. (428 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (363 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (505 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (190 aa)
ptsPTS system, sucrose-specific IIC component (trunca; Truncated. (377 aa)
MSC_0219DNA METHYLASE. (190 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (297 aa)
sunSun family protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (432 aa)
dcmCytosine-specific DNA-methyltransferase Sau96I; Deleted EC_number 2.1.1.73. (341 aa)
modAdenine-specific DNA-methyltransferase. (222 aa)
MSC_0188Hypothetical protein. (253 aa)
MSC_0186DNA methylase. (662 aa)
trmBMETHYLTRANSFERASE; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (221 aa)
ptsG-2PTS SYSTEM, GLUCOSE-SPECIFIC IIBC COMPONENT; Truncated. (177 aa)
clsCardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (509 aa)
hemKProtoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (282 aa)
tdkThymidine kinase. (209 aa)
MSC_0133Hypothetical protein. (142 aa)
nagEPTS system, N-acetylglucosamine-specific IIBC component. (557 aa)
plsYConserved hypothetical transmembrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (258 aa)
galUUTP-GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE. (290 aa)
cpsGlycosyltransferase. (304 aa)
epsGGlycosyltransferase. (449 aa)
ribC/ribFRiboflavin kinase / FAD synthetase. (250 aa)
hlyATruncated. (149 aa)
coaEDEPHOSPHO-COA KINASE; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (189 aa)
polADNA POLYMERASE I, 5'-3' exonuclease. (304 aa)
gcpO-SIALOGLYCOPROTEIN ENDOPEPTIDASE; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (319 aa)
ptsGPTS system, glucose-specific IIABC component. (580 aa)
dnaXDNA polymerase III gamma-tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (652 aa)
tmkTHYMIDYLATE KINASE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
holBDNA polymerase III delta subunit. (246 aa)
MSC_0044Methyltransferase. (240 aa)
EIIBC-mtlPTS SYSTEM, MANNITOL-PERMEASE IIBC COMPONENT. (520 aa)
EIIA-mtlPTS SYSTEM, MANNITOL-PERMEASE IIA COMPONENT. (142 aa)
ksgADimethyladenosine transferase KsgA; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (266 aa)
dnaNDNA POLYMERASE III, BETA CHAIN. (375 aa)
Your Current Organism:
Mycoplasma mycoides
NCBI taxonomy Id: 272632
Other names: M. mycoides subsp. mycoides SC str. PG1, Mycoplasma mycoides subsp. mycoides SC str. PG1, Mycoplasma mycoides subsp. mycoides SC strain PG1
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