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atpF atpF pmd1 pmd1 msbA msbA glpF glpF ptsH ptsH potA potA potB potB potI potI R02_orf469 R02_orf469 fruA fruA R02_orf1386V R02_orf1386V glnQ glnQ ugpC ugpC ugpA ugpA ugpE ugpE secY secY cysA cysA hisP hisP ptsG ptsG secA secA oppB oppB amiD amiD oppD oppD oppF oppF secG secG yjcW yjcW trx trx bcrA bcrA P37 P37 P29 P29 P69 P69 artP artP cbiO cbiO ntpJ ntpJ yjfU yjfU ulaB ulaB yjfS yjfS LcnDR3 LcnDR3 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpE atpE atpB atpB pstB pstB pstA pstA ptsI ptsI mtlA mtlA mtlF mtlF yidC yidC devA devA K05_orf1882 K05_orf1882 cysA-2 cysA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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atpFATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (207 aa)
pmd1Transport ATP-binding protein; MPN018(new), 136(Himmelreich et al., 1996). (623 aa)
msbATransport ATP-binding protein; MPN019(new), 135(Himmelreich et al., 1996). (634 aa)
glpFGlycerol uptake facilitator; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). (264 aa)
ptsHPhosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (88 aa)
potASpermidine/putrescine transport ATP-binding prot; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (560 aa)
potBSpermidine/putrescine transport system permease; Required for the activity of the bacterial transport system of putrescine and spermidine; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (286 aa)
potISpermidine/putrescine transport system permease; Required for the activity of the bacterial transport system of putrescine and spermidine; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (286 aa)
R02_orf469Hypothetical protein; MPN077(new), 078(Himmelreich et al., 1996); see: MPN076. (546 aa)
fruAFructose-permease IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. (694 aa)
R02_orf1386VProbably ABC transporter membrane protein subunit; MPN080(new), 075(Himmelreich et al., 1996). (1386 aa)
glnQGlutamine transport ATP-binding protein; MPN081(new), 074(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (465 aa)
ugpCSn-glycerol-3-phosphate transport system permease protein; MPN134(new), 021(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (586 aa)
ugpASn-glycerol-3-phosphate transport system permease protein; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. (329 aa)
ugpESn-glycerol-3-phosphate transport system permease protein; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. (319 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (477 aa)
cysACobalt transport ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (274 aa)
hisPCobalt transport ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (303 aa)
ptsGPTS system, glucose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. (940 aa)
secAPreprotein translocase SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (808 aa)
oppBOligopeptide transport system permease protein OppB; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (389 aa)
amiDOligopeptide transport system permease protein AmiD; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (376 aa)
oppDOligopeptide transport ATP-binding protein OppD; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily. (423 aa)
oppFOppF; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily. (851 aa)
secGSecG; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. (76 aa)
yjcWSugar (ribose/galactose) ABC transporter ATP-binding subunit; Part of the ABC transporter complex involved in carbohydrates import. Probably responsible for energy coupling to the transport system (By similarity). (572 aa)
trxThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (102 aa)
bcrAABC transporter ATP-binding protein; MPN334(new), 503(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (326 aa)
P37High affinity transport system protein P37; P37 is part of a high-affinity transport system. (380 aa)
P29ATP-binding protein P29; Part of a high-affinity transport system. (244 aa)
P69Transport system permease protein P69; Probably part of a high-affinity transport system. (542 aa)
artPAbc transport ATP-binding protein; MPN432(new), 408(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (382 aa)
cbiOAbc transport ATP-binding protein; MPN433(new), 407(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (270 aa)
ntpJKtrB; MPN460(new), 380(Himmelreich et al., 1996). (565 aa)
yjfUPhosphotransferase protein II, component A-like protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (159 aa)
ulaBPTS system: EIIB-like protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (95 aa)
yjfSPhosphotransferase protein-like protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. Belongs to the UlaA family. (660 aa)
LcnDR3Hemolysin ABC-type exporter-like protein; MPN571(new), 271(Himmelreich et al., 1996). (660 aa)
atpCATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa)
atpDATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (475 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (279 aa)
atpAATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (518 aa)
atpHATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa)
atpEATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (105 aa)
atpBATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (293 aa)
pstBPhosphate specific; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (329 aa)
pstAPsta /Pstc-like ABC transporter; Could be part of a binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (651 aa)
ptsIPEP-dependent HPr protein kinase phosphoryltransferase (Enzyme I); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (572 aa)
mtlAMannitol-specific PRS EIIBC-like protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (379 aa)
mtlFPTS system mannitol-specific component IIA; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (143 aa)
yidCConserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). (385 aa)
devAABC transporter subunit; MPN683(new), 159(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (339 aa)
K05_orf1882Conserved hypothetical protein; MPN684(new), 158(Himmelreich et al., 1996); possible membrane transporter component. (1882 aa)
cysA-2Sulfate transport ATP-binding protein; MPN685(new), 157(Himmelreich et al., 1996); Belongs to the ABC transporter superfamily. (284 aa)
Your Current Organism:
Mycoplasma pneumoniae M129
NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129
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