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MYPU_0170 MYPU_0170 MYPU_0210 MYPU_0210 MYPU_0220 MYPU_0220 MYPU_0320 MYPU_0320 MYPU_0430 MYPU_0430 MYPU_0460 MYPU_0460 MYPU_0520 MYPU_0520 MYPU_0550 MYPU_0550 MYPU_0890 MYPU_0890 MYPU_0970 MYPU_0970 MYPU_1030 MYPU_1030 MYPU_1100 MYPU_1100 MYPU_1140 MYPU_1140 MYPU_1270 MYPU_1270 MYPU_1290 MYPU_1290 MYPU_1310 MYPU_1310 MYPU_1450 MYPU_1450 MYPU_1620 MYPU_1620 MYPU_1680 MYPU_1680 MYPU_1720 MYPU_1720 MYPU_1730 MYPU_1730 MYPU_1860 MYPU_1860 MYPU_1980 MYPU_1980 MYPU_2000 MYPU_2000 MYPU_2010 MYPU_2010 MYPU_2200 MYPU_2200 MYPU_2210 MYPU_2210 MYPU_2280 MYPU_2280 MYPU_2350 MYPU_2350 MYPU_2360 MYPU_2360 MYPU_2370 MYPU_2370 MYPU_2380 MYPU_2380 MYPU_2400 MYPU_2400 MYPU_2460 MYPU_2460 MYPU_2580 MYPU_2580 MYPU_2650 MYPU_2650 MYPU_2660 MYPU_2660 MYPU_2670 MYPU_2670 MYPU_2680 MYPU_2680 MYPU_2690 MYPU_2690 MYPU_2700 MYPU_2700 MYPU_2710 MYPU_2710 MYPU_2720 MYPU_2720 MYPU_2770 MYPU_2770 MYPU_2780 MYPU_2780 MYPU_2950 MYPU_2950 MYPU_3140 MYPU_3140 MYPU_3150 MYPU_3150 MYPU_3220 MYPU_3220 MYPU_3350 MYPU_3350 MYPU_3360 MYPU_3360 MYPU_3390 MYPU_3390 MYPU_3580 MYPU_3580 MYPU_3600 MYPU_3600 MYPU_3620 MYPU_3620 MYPU_3630 MYPU_3630 MYPU_3640 MYPU_3640 MYPU_3690 MYPU_3690 MYPU_3750 MYPU_3750 MYPU_3790 MYPU_3790 MYPU_4410 MYPU_4410 MYPU_4430 MYPU_4430 MYPU_4490 MYPU_4490 MYPU_4500 MYPU_4500 MYPU_4580 MYPU_4580 MYPU_4590 MYPU_4590 MYPU_4730 MYPU_4730 MYPU_4740 MYPU_4740 MYPU_4830 MYPU_4830 MYPU_4900 MYPU_4900 MYPU_5110 MYPU_5110 MYPU_5180 MYPU_5180 MYPU_5370 MYPU_5370 MYPU_5380 MYPU_5380 MYPU_5390 MYPU_5390 MYPU_5410 MYPU_5410 MYPU_5480 MYPU_5480 MYPU_5510 MYPU_5510 MYPU_5670 MYPU_5670 MYPU_5940 MYPU_5940 MYPU_5950 MYPU_5950 MYPU_5960 MYPU_5960 MYPU_5970 MYPU_5970 MYPU_5980 MYPU_5980 MYPU_5990 MYPU_5990 MYPU_6010 MYPU_6010 MYPU_6120 MYPU_6120 MYPU_6230 MYPU_6230 MYPU_6320 MYPU_6320 MYPU_6330 MYPU_6330 MYPU_6440 MYPU_6440 MYPU_6450 MYPU_6450 MYPU_6460 MYPU_6460 MYPU_6650 MYPU_6650 MYPU_6660 MYPU_6660 MYPU_6810 MYPU_6810 MYPU_6820 MYPU_6820 MYPU_6830 MYPU_6830 MYPU_6840 MYPU_6840 MYPU_6870 MYPU_6870 MYPU_6920 MYPU_6920 MYPU_6990 MYPU_6990 MYPU_7000 MYPU_7000 MYPU_7020 MYPU_7020 MYPU_7180 MYPU_7180 MYPU_7210 MYPU_7210 MYPU_7250 MYPU_7250 MYPU_7260 MYPU_7260 MYPU_7500 MYPU_7500 MYPU_7510 MYPU_7510 MYPU_7590 MYPU_7590 MYPU_7610 MYPU_7610 MYPU_7620 MYPU_7620 MYPU_7630 MYPU_7630 MYPU_7640 MYPU_7640
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MYPU_0170Glucose PTS system EIICBA or EIICB component; Identified by sequence similarity; putative; similar to SWISS-PROT:P20166 (PTGA_BACSU) Blastp2 P=9e-64 C=29% Pfscan: pos. 656-765 PF00358 | PTS_EIIA_1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PDO pos. 531-565 PF00367 | PTS_EIIB phosphotransferase system, EIIB (PDOC00795) pos. 686-738 GC0246 | PTS_EII_EIII_1 PTS EII/EIII components phosphorylation site sig pos. 706-718 PS00371 | PTS_EIIA_1 PTS EIIA domains phosphorylation site signature 1. (791 aa)
MYPU_0210DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF PYRUVATE COMPLEX); Identified by sequence similarity; possible; similar to SWISS-PROT:P47513 (DLDH_MYCGE) Blastp2 P=4e-74 C=53%. (455 aa)
MYPU_0220MGPA-LIKE (Mycoplasma genitalium) PROTEIN; Identified by sequence similarity; possible; similar to SWISS-PROT:P22746 (MGPA_MYCGE) Blastp2 P=6e-59 C=57% Pfscan: pos. 12-315 PF01368 | DHH DHH family; Sperker, B. et al., 1991. Molecular Microbiology. 5:299-306. Inamine, I. et al., 1988. Gene. 73:175-183. (324 aa)
MYPU_0320LIPOATE-PROTEIN LIGASE A; Identified by sequence similarity; possible; similar to SWISS-PROT:P75394 (LPLA_MYCPN) Blastp2 P=5e-67 C=58%. (345 aa)
MYPU_0430CPG DNA METHYLASE (CYTOSINE-SPECIFIC METHYLTRANSFERASE); Identified by sequence similarity; possible; similar to SWISS-PROT:P15840 (MTSI_SPISQ) Blastp2 P=5e-46 C=51%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (296 aa)
MYPU_0460GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; Identified by sequence similarity; probable; similar to SWISS-PROT:P75358 (G3P_MYCPN) Blastp2 P=0 C=69%; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (349 aa)
MYPU_0520THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (234 aa)
MYPU_05505'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. (565 aa)
MYPU_0890CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE); Identified by sequence similarity; possible; similar to SWISS-PROT:P38493 (KCY_BACSU) Blastp2 P=8e-30 C=58%. (223 aa)
MYPU_0970LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN KDTB HOMOLOG; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (149 aa)
MYPU_1030Oligo-1,6-glucosidase; Identified by sequence similarity; possible; similar to SWISS-PROT:P29094 (O16G_BACTR) Blastp2 P=5e-93 C=55%. (544 aa)
MYPU_1100FRUCTOSE-BISPHOSPHATE ALDOLASE; Identified by sequence similarity; probable; similar to SWISS-PROT:P75089 (ALF_MYCPN) Blastp2 P=3e-81 C=68%. (286 aa)
MYPU_11401-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by sequence similarity; possible; similar to SWISS-PROT:P75479 (PLSC_MYCPN) Blastp2 P=2e-24 C=48%. (255 aa)
MYPU_1270RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
MYPU_1290Fructose PTS system EIIBC or EIIC component; Identified by sequence similarity; possible; similar to SWISS-PROT:P47308 (PTFA_MYCGE) Blastp2 P=0 C=54% Pfscan: pos. 25-68 PF00359 | PTS_EIIA_2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2. (698 aa)
MYPU_1310GLUCOSE-6-PHOSPHATE ISOMERASE (PHOSPHOGLUCOSE ISOMERASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P13376 (G6PB_BACST) Blastp2 P=3e-98 C=63%. (427 aa)
MYPU_1450THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. (190 aa)
MYPU_1620FATTY ACID/PHOSPHOLIPID SYNTHESIS PROTEIN PLSX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (325 aa)
MYPU_1680CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase; Identified by sequence similarity; possible; similar to SWISS-PROT:P47360 (PGSA_MYCGE) Blastp2 P=1e-29 C=58%; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (205 aa)
MYPU_1720NITROGEN FIXATION PROTEIN NIFS; Identified by sequence similarity; possible; similar to SWISS-PROT:Q49420 (NISH_MYCGE) Blastp2 P=2e-37 C=47%. (393 aa)
MYPU_1730NITROGEN FIXATION PROTEIN NIFS; Identified by sequence similarity; possible; similar to SWISS-PROT:Q49420 (NISH_MYCGE) Blastp2 P=4e-48 C=49%. (387 aa)
MYPU_1860CPG DNA METHYLASE (CYTOSINE-SPECIFIC METHYLTRANSFERASE SSSI); Identified by sequence similarity; possible; similar to SWISS-PROT:P15840 (MTSI_SPISQ) Blastp2 P=4e-22 C=44%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (264 aa)
MYPU_1980TRANSPORT PROTEIN SGAT, LIPOPROTEIN; Identified by sequence similarity; putative; similar to SWISS-PROT:P39301 (SGAT_ECOLI) Blastp2 P=4e-34 C=26% Pfscan: pos. 34-326 PF01032 | FECCD_FAMILY FecCD transport family (PDOC00364) pos. 36-46 PS00013 | PROKAR_LIPOPROTEIN Prokaryotic membrane lipoprotein lipid attachment site pos. 571-578 PS00867 | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. (651 aa)
MYPU_2000GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (GLU-ADT SUBUNIT A); Identified by sequence similarity; possible; similar to SWISS-PROT:P47345 (GATA_MYCGE) Blastp2 P=4e-68 C=54%. (448 aa)
MYPU_2010Conserved hypothetical protein; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (494 aa)
MYPU_2200URIDYLATE KINASE (UK) (URIDINE MONOPHOSPHATE KINASE) (UMP KINASE); Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa)
MYPU_2210GLYCEROL KINASE (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE) (GLYCEROKINASE) (GK); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
MYPU_2280GLUCOKINASE (GLUCOSE KINASE); Identified by sequence similarity; putative; similar to SWISS-PROT:Q44406 (XYLR_ANATH) Blastp2 P=8e-16 C=42%. (287 aa)
MYPU_2350ATP SYNTHASE ALPHA CHAIN; Identified by sequence similarity; possible; similar to SWISS-PROT:P33252 (ATPA_MYCGA) Blastp2 P=2e-89 C=50%. (529 aa)
MYPU_2360ATP SYNTHASE BETA CHAIN; Identified by sequence similarity; possible; similar to SWISS-PROT:O50292 (ATPB_AQUPY) Blastp2 P=4e-91 C=37%. (698 aa)
MYPU_2370PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE); Identified by sequence similarity; possible; similar to SWISS-PROT:P39646 (PTA_BACSU) Blastp2 P=8e-50 C=43%. (318 aa)
MYPU_2380ACETATE KINASE (ACETOKINASE); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
MYPU_2400PYRUVATE KINASE (PK); Identified by sequence similarity; probable; similar to SWISS-PROT:P78031 (KPYK_MYCPN) Blastp2 P=7e-95 C=59%; Belongs to the pyruvate kinase family. (475 aa)
MYPU_2460PHOSPHOGLYCERATE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:O32756 (PGK_LACDE) Blastp2 P=0 C=35%; In the N-terminal section; belongs to the phosphoglycerate kinase family. (771 aa)
MYPU_2580FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (272 aa)
MYPU_2650ATP SYNTHASE EPSILON CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa)
MYPU_2660ATP SYNTHASE BETA CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (475 aa)
MYPU_2670ATP SYNTHASE GAMMA CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (279 aa)
MYPU_2680ATP SYNTHASE ALPHA CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (528 aa)
MYPU_2690ATP SYNTHASE DELTA CHAIN; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (179 aa)
MYPU_2700ATP SYNTHASE B CHAIN; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (180 aa)
MYPU_2710ATP SYNTHASE C CHAIN; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (92 aa)
MYPU_2720ATP SYNTHASE A CHAIN; Identified by sequence similarity; putative; similar to SWISS-PROT:P33251 (ATP6_MYCGA) Blastp2 P=3e-18 C=36%. (270 aa)
MYPU_2770PHOSPHOPENTOMUTASE (PHOSPHODEOXYRIBOMUTASE); Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (395 aa)
MYPU_2780DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P32321 (DCTD_HUMAN) Blastp2 P=5e-38 C=66%. (154 aa)
MYPU_2950Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (224 aa)
MYPU_3140DEOXYRIBOSE-PHOSPHATE ALDOLASE (PHOSPHODEOXYRIBOALDOLASE) (DEOXYRIBOALDOLASE); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (229 aa)
MYPU_3150URACIL PHOSPHORIBOSYLTRANSFERASE (UMP PYROPHOSPHORYLASE) (UPRTASE); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
MYPU_3220ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
MYPU_3350Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (366 aa)
MYPU_3360MTA/SAH NUCLEOSIDASE [INCLUDES: 5'-METHYLTHIOADENOSINE NUCLEOSIDASE (EC 3.2.2.16); Identified by sequence similarity; putative; similar to TREMBL:O50860 (O50860) Blastp2 P=4e-10 C=48% Pfscan: pos. 14-220 PF01048 | PNP_UDP_1 Phosphorylase family (PDOC00946). (227 aa)
MYPU_3390SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
MYPU_3580ACYL CARRIER PROTEIN (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (73 aa)
MYPU_3600FRUCTOSE-BISPHOSPHATE ALDOLASE; Identified by sequence similarity; possible; similar to SWISS-PROT:P47269 (ALF_MYCGE) Blastp2 P=4e-31 C=51%. (280 aa)
MYPU_3620Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (256 aa)
MYPU_3630N-ACETYLMANNOSAMINE-6-P EPIMERASE; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (228 aa)
MYPU_3640Glucose PTS system EIICB or EIICBA component; Identified by sequence similarity; possible; similar to SWISS-PROT:P20166 (PTGA_BACSU) Blastp2 P=2e-54 C=39% Pfscan: pos. 529-562 PF00367 | PTS_EIIB phosphotransferase system, EIIB (PDOC00795) pos. 540-557 PS01035 | PTS_EIIB_CYS PTS EIIB domains cysteine phosphorylation site signature. (602 aa)
MYPU_3690N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE (GLCNAC 6-P DEACETYLASE); Identified by sequence similarity; possible; similar to SWISS-PROT:O34450 (NAGA_BACSU) Blastp2 P=2e-32 C=52%. (253 aa)
MYPU_3750AMINOPEPTIDASE (LEUCINE AMINOPEPTIDASE) (LAP); Identified by sequence similarity; possible; similar to SWISS-PROT:P47707 (AMPL_MYCSA) Blastp2 P=1e-90 C=55% Pfscan: pos. 40-432 PF00883 | PEPTIDASE_M17 Cytosol aminopeptidase family (PDOC00548). (459 aa)
MYPU_3790CYTIDINE DEAMINASE (CYTIDINE AMINOHYDROLASE) (CDA); This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (112 aa)
MYPU_4410GLYCINE CLEAVAGE SYSTEM H PROTEIN; Identified by sequence similarity; putative; similar to TREMBL:Q9WY55 (Q9WY55) Blastp2 P=9e-10 C=51%. (111 aa)
MYPU_4430LIPOATE-PROTEIN LIGASE A; Identified by sequence similarity; putative; similar to SWISS-PROT:P75394 (LPLA_MYCPN) Blastp2 P=2e-28 C=46%. (344 aa)
MYPU_4490ATP SYNTHASE ALPHA CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa)
MYPU_4500ATP SYNTHASE BETA CHAIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa)
MYPU_4580TRIOSEPHOSPHATE ISOMERASE(TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
MYPU_45902,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
MYPU_4730Conserved hypothetical protein; Identified by sequence similarity; possible; similar to TREMBL:Q9WZY5 (Q9WZY5) Blastp2 P=2e-13 C=48%. (224 aa)
MYPU_4740Phosphatidate cytidylyltransferase; Identified by sequence similarity; putative; similar to SWISS-PROT:P44937 (CDSA_HAEIN) Blastp2 P=2e-12 C=22%. (323 aa)
MYPU_4830Conserved hypothetical protein; Identified by sequence similarity; possible; similar to TREMBL:Q9WYU5 (Q9WYU5) Blastp2 P=5e-36 C=50%; Belongs to the NAPRTase family. (334 aa)
MYPU_4900METHIONYL-TRNA SYNTHETASE (METHIONINE--TRNA LIGASE) (METRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (509 aa)
MYPU_5110TRANSKETOLASE (TK); Identified by sequence similarity; probable; similar to SWISS-PROT:P45694 (TKT_BACSU) Blastp2 P=0 C=63%; Belongs to the transketolase family. (615 aa)
MYPU_5180ENOLASE (2-PHOSPHOGLYCERATE DEHYDRATASE) (2-PHOSPHO-D-GLYCERATE HYDRO-LYASE); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (456 aa)
MYPU_5370DIHYDROFOLATE REDUCTASE; Identified by sequence similarity; probable; similar to SWISS-PROT:P47470 (DYR_MYCGE) Blastp2 P=6e-39 C=64%; Belongs to the dihydrofolate reductase family. (179 aa)
MYPU_5380THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (286 aa)
MYPU_5390RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN (RIBONUCLEOTIDE REDUCTASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P75461 (RIR2_MYCPN) Blastp2 P=0 C=77%. (341 aa)
MYPU_5410RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE REDUCTASE); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (711 aa)
MYPU_5480RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF [INCLUDES: RIBOFLAVIN KINASE (FLAVOKINASE); Identified by sequence similarity; putative; similar to TREMBL:Q9WZW1 (Q9WZW1) Blastp2 P=2e-13 C=33%. (279 aa)
MYPU_5510HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) (HGPRTASE); Identified by sequence similarity; possible; similar to SWISS-PROT:P37472 (HPRT_BACSU) Blastp2 P=2e-38 C=61%; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (193 aa)
MYPU_5670ADENYLATE KINASE (ATP-AMP TRANSPHOSPHORYLASE); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
MYPU_5940TRANSPORT PROTEIN SGAT; Identified by sequence similarity; possible; similar to SWISS-PROT:P75291 (SGAT_MYCPN) Blastp2 P=0 C=46% Pfscan: pos. 79-503 PF00324 | AA_PERMEASES Amino acid permease (PDOC00191). (594 aa)
MYPU_5950PENTITOL PHOSPHOTRANSFERASE ENZYME II, B COMPONENT; Identified by sequence similarity; possible; similar to SWISS-PROT:P39302 (PTXB_ECOLI) Blastp2 P=2e-11 C=51%. (96 aa)
MYPU_5960PENTITOL PHOSPHOTRANSFERASE ENZYME II, A COMPONENT; Identified by sequence similarity; probable; similar to SWISS-PROT:P75292 (PTXA_MYCPN) Blastp2 P=3e-34 C=67% Pfscan: pos. 28-91 PF00359 | PTS_EIIA_2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2. (159 aa)
MYPU_5970HEXULOSE-6-PHOSPHATE SYNTHASE (HUMPS) (D-ARABINO 3-HEXULOSE 6-PHOSPHATE FORMALDEHYDE LYASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P75293 (SGAH_MYCPN) Blastp2 P=6e-77 C=69%. (232 aa)
MYPU_5980HEXULOSE-6-PHOSPHATE ISOMERASE (HUMPI); Identified by sequence similarity; probable; similar to SWISS-PROT:P75294 (SGAU_MYCPN) Blastp2 P=1e-75 C=62%. (305 aa)
MYPU_5990SUGAR ISOMERASE SGAE; Identified by sequence similarity; probable; similar to SWISS-PROT:P75289 (SGAE_MYCPN) Blastp2 P=1e-83 C=73%. (243 aa)
MYPU_60106-PHOSPHOFRUCTOKINASE (PHOSPHOFRUCTOKINASE) (PHOSPHOHEXOKINASE); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (326 aa)
MYPU_6120RIBOSE-5-PHOSPHATE ISOMERASE; Identified by sequence similarity; possible; similar to SWISS-PROT:P47636 (Y396_MYCGE) Blastp2 P=8e-26 C=55%. (155 aa)
MYPU_6230NH(3)-DEPENDENT NAD(+) SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (257 aa)
MYPU_6320ALPHA-AMYLASE 3 (1,4-ALPHA-D-GLUCAN GLUCANOHYDROLASE); Identified by sequence similarity; putative; similar to SWISS-PROT:P14899 (AMY3_DICTH) Blastp2 P=3e-46 C=37% Pfscan: 13-23 PS00013 | PROKAR_LIPOPROTEIN Prokaryotic membrane lipoprotein lipid attachment site. (607 aa)
MYPU_6330Oligo-1,6-glucosidase; Identified by sequence similarity; possible; similar to SWISS-PROT:P29094 (O16G_BACTR) Blastp2 P=3e-95 C=58%. (544 aa)
MYPU_6440PULLULANASE PRECURSOR (ALPHA-DEXTRIN ENDO-1,6-ALPHA-GLUCOSIDASE) (PULLULAN 6-GLUCANOHYDROLASE); Identified by sequence similarity; putative; similar to SWISS-PROT:O33840 (PULA_THEMA) Blastp2 P=8e-41 C=36%; Belongs to the glycosyl hydrolase 13 family. (691 aa)
MYPU_6450PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP); Identified by sequence similarity; probable; similar to SWISS-PROT:P47295 (DEOD_MYCGE) Blastp2 P=3e-47 C=63%. (232 aa)
MYPU_6460THYMIDINE PHOSPHORYLASE (TDRPASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P77836 (PDP_BACST) Blastp2 P=0 C=68%. (430 aa)
MYPU_6650CARDIOLIPIN SYNTHETASE; Identified by sequence similarity; putative; similar to SWISS-PROT:P31071 (CLS_ECOLI) Blastp2 P=3e-29 C=37% Pfscan: pos. 241-268 PS50035 | PLD_DOMAIN Phospholipase D/Transphosphatidylase pos. 241-268 PF00614 | PLDC Phospholipase D. Active site motif. (501 aa)
MYPU_6660CTP SYNTHASE (UTP--AMMONIA LIGASE) (CTP SYNTHETASE); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (539 aa)
MYPU_6810GLUTAMYL TRNA SYNTHETASE (FRAGMENT) (GLUTAMATE--TRNA LIGASE) (GLURS); Identified by sequence similarity; probable; similar to TREMBL:Q50355 (Q50355) Blastp2 P=2e-66 C=100%; Dybvig K., Yu H; Regulation of a restriction and modification system via DNA inversion in Mycoplasma pulmonis.; Mol. Microbiol. 12:547-560(1994). (126 aa)
MYPU_6820GLUTAMYL-TRNA SYNTHETASE (GLUTAMATE--TRNA LIGASE) (GLURS); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (468 aa)
MYPU_6830RIBULOSE-PHOSPHATE 3-EPIMERASE (PENTOSE-5-PHOSPHATE 3-EPIMERASE) (PPE) (R5P3E); Identified by sequence similarity; possible; similar to SWISS-PROT:Q9ZJ75 (RPE_HELPJ) Blastp2 P=9e-25 C=52%. (215 aa)
MYPU_6840Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (272 aa)
MYPU_6870GUANYLATE KINASE (GMP KINASE); Essential for recycling GMP and indirectly, cGMP. (196 aa)
MYPU_6920MGPA-LIKE (Mycoplasma genitalium) PROTEIN; Identified by sequence similarity; probable; similar to SWISS-PROT:P75144 (MGPA_MYCPN) Blastp2 P=3e-75 C=64%; Sperker, B. et al., 1991. Molecular Microbiology. 5:299-306. Inamine, I. et al., 1988. Gene. 73:175-183. (324 aa)
MYPU_6990ATP SYNTHASE BETA CHAIN; Identified by sequence similarity; probable; similar to SWISS-PROT:P43451 (ATPB_ENTHR) Blastp2 P=1e-99 C=59%. (468 aa)
MYPU_7000ATP SYNTHASE ALPHA CHAIN; Identified by sequence similarity; possible; similar to SWISS-PROT:P29706 (ATPA_PROMO) Blastp2 P=2e-62 C=45%. (509 aa)
MYPU_7020S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (376 aa)
MYPU_7180PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THII; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (379 aa)
MYPU_7210Conserved hypothetical protein; Identified by sequence similarity; similar to TREMBL:O25502 Blastp2 P=2e-9 score=62.5 Pfscan: pos. 1-171 PF01121 | UPF0038 Uncharacterized protein family UPF0038 (PDOC00996) pos. 6-13 PS00017 | ATP_GTP_A ATP/GTP-binding site motif A (P-loop); Belongs to the CoaE family. (172 aa)
MYPU_7250MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE); Identified by sequence similarity; possible; similar to SWISS-PROT:Q59935 (MANA_STRMU) Blastp2 P=1e-31 C=40%. (303 aa)
MYPU_7260AMINOPEPTIDASE (LEUCINE AMINOPEPTIDASE) (LAP); Identified by sequence similarity; probable; similar to SWISS-PROT:P47707 (AMPL_MYCSA) Blastp2 P=0 C=66%; Pfscan: pos. 24-429 PF00883 | PEPTIDASE_M17 Cytosol aminopeptidase family (PDOC00548) pos. 310-317 PS00631 | CYTOSOL_AP Cytosol aminopeptidase signature. (454 aa)
MYPU_7500MANNITOL-1-PHOSPHATE 5-DEHYROGENASE; Identified by sequence similarity; possible; similar to SWISS-PROT:P78008 (MTLD_MYCPN) Blastp2 P=2e-65 C=61%. (360 aa)
MYPU_7510Mannitol PTS system EIICBA or EIICB component; Identified by sequence similarity; possible; similar to SWISS-PROT:P50852 (PTMB_BACST) Blastp2 P=3e-49 C=50%. (342 aa)
MYPU_7590L-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa)
MYPU_7610DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF PYRUVATE COMPLEX); Identified by sequence similarity; possible; similar to SWISS-PROT:P47513 (DLDH_MYCGE) Blastp2 P=0 C=45%. (627 aa)
MYPU_7620DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; Identified by sequence similarity; possible; similar to SWISS-PROT:P21883 (ODP2_BACSU) Blastp2 P=4e-54 C=53%. (315 aa)
MYPU_7630PYRUVATE DEHYDROGENASE E1 COMPONENT, BETA SUBUNIT; Identified by sequence similarity; probable; similar to SWISS-PROT:P75391 (ODPB_MYCPN) Blastp2 P=0 C=74%. (332 aa)
MYPU_7640PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (368 aa)
Your Current Organism:
Mycoplasma pulmonis
NCBI taxonomy Id: 272635
Other names: M. pulmonis UAB CTIP, Mycoplasma pulmonis UAB CTIP, Mycoplasma pulmonis str. UAB CTIP, Mycoplasma pulmonis strain UAB CTIP
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