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trpC trpC trpD trpD trpE trpE trpG trpG trpF trpF trpB1 trpB1 trpA trpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpCtrpC indole-3-glycerol phosphate synthase (EC 4.1.1.48) (IGPS); Belongs to the TrpC family. (229 aa)
trpDtrpD anthranilate synthase component II (EC 4.1.3.27); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa)
trpEtrpE anthranilate synthase component I (EC 4.1.3.27); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismat [...] (434 aa)
trpGtrpG anthranilate synthase component II (EC 4.1.3.27). (190 aa)
trpFtrpF phosphoribosyl anthranilate isomerase (EC 5.3.1.24); Belongs to the TrpF family. (208 aa)
trpB1trpB tryptophan synthase, subunit beta (EC 4.2.1.20); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (388 aa)
trpAtrpA tryptophan synthase, subunit alpha (EC 4.2.1.20); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (248 aa)
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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