STRINGSTRING
cdc6 cdc6 rps15P rps15P rpl37AE rpl37AE rps24E rps24E rpl39E rpl39E hpyA1-2 hpyA1-2 han1 han1 PAB3084 PAB3084 rpl14 rpl14 top6A top6A rps4e rps4e rpl22 rpl22 PAB2357 PAB2357 rpl11 rpl11 nusG nusG priS priS priL priL PAB2180 PAB2180 rpl15 rpl15 rpl30 rpl30 rps5 rps5 rpl18 rpl18 rpl19e rpl19e rpl32e rpl32e rpl6 rpl6 rps8 rps8 rpl5 rpl5 rpl24 rpl24 rps17 rps17 rps3 rps3 rps19 rps19 rpl2 rpl2 rpl4 rpl4 rpl3 rpl3 PAB2119 PAB2119 smc smc PAB2107 PAB2107 PAB2042 PAB2042 nep1 nep1 cetZ cetZ rps19e rps19e rbcL rbcL rpl10e rpl10e topA topA rps6e rps6e rpl44e rpl44e rpl12 rpl12 rpl10 rpl10 rpl1 rpl1 polI polI PAB0838 PAB0838 rad32 rad32 rps8E rps8E PAB0737 PAB0737 rpl21E rpl21E PAB0642 PAB0642 rpl15E rpl15E obg-like obg-like rps10P rps10P rpl7AE rpl7AE rps7P rps7P rps12P rps12P PAB0418 PAB0418 top6B top6B PAB0406 PAB0406 rps2P rps2P rps9P rps9P rpl13P rpl13P rpl18E rpl18E rps11P rps11P rps4P rps4P rps13P rps13P PAB0329 PAB0329 dnaG dnaG rps3AE rps3AE PAB0258 PAB0258 PAB0176 PAB0176 PAB0113 PAB0113 PAB0112 PAB0112 rfcL rfcL rfcS rfcS rpl24E rpl24E rpl29 rpl29 rps27e rps27e rplXA rplXA rpl31E rpl31E rpl14E rpl14E rpL34E rpL34E nop10 nop10 rpl40E rpl40E rps17e rps17e rps28E rps28E rpl37E rpl37E rpl30E rpl30E albA albA rpl35ae rpl35ae rpl23 rpl23 rps14 rps14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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cdc6Cdc6/orc1 cell division control protein 6; Involved in regulation of DNA replication (By similarity). Binds specifically to the oriC region. (432 aa)
rps15Prps15P SSU ribosomal protein S15P. (158 aa)
rpl37AErpl37AE LSU ribosomal protein L37AE; Binds to the 23S rRNA. (83 aa)
rps24Erps24E SSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (99 aa)
rpl39Erpl39E LSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
hpyA1-2hpyA1-2 archaeal histone a1/a2; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (67 aa)
han1Han1 histone-like protein han1 subunit; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (67 aa)
PAB3084Hypothetical protein. (94 aa)
rpl14rpl14P LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
top6ATop6A DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (382 aa)
rps4erps4E SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa)
rpl22rpl22P LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (155 aa)
PAB2357Component of the U3 small nucleolar ribonucleoprotein, imp4 homolog; Probably involved in the biogenesis of the ribosome. (224 aa)
rpl11rpl11P LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (164 aa)
nusGnusG transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa)
priSDNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own, synthesizing DNA strands up to 3 kB. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability for RNA fragments up to 150 bases. The DNA polymerase activity may enable DNA primase t [...] (345 aa)
priLEukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Displays gap-filling and strand-displacement activities. (393 aa)
PAB2180Hypothetical protein, containing ATP/GTP-binding site motif A; Belongs to the UPF0273 family. (247 aa)
rpl15rpl15P LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpl30rpl30P LSU ribosomal protein L30P. (155 aa)
rps5rps5P SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (236 aa)
rpl18rpl18P LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (203 aa)
rpl19erpl19E LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (151 aa)
rpl32erpl32E LSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (130 aa)
rpl6rpl6P LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa)
rps8rps8E SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl5rpl5P LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (188 aa)
rpl24rpl24P LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa)
rps17rps17P SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (116 aa)
rps3rps3P SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (210 aa)
rps19rps19P SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (132 aa)
rpl2rpl2P LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rpl4rpl4P LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa)
rpl3rpl3P LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (361 aa)
PAB2119Hypothetical protein. (258 aa)
smcSmc1 chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1177 aa)
PAB2107TBP-interacting protein, TIP49 homolog. (441 aa)
PAB2042Hypothetical protein, containing PIN domain. (139 aa)
nep1Hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA (By similarity). (232 aa)
cetZftsZ-3 cell division GTPase, ftsZ homolog; Involved in cell shape control; Belongs to the CetZ family. (365 aa)
rps19erps19E SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
rbcLrbcL ribulose bisphosphate carboxylase, large subunit (EC 4.1.1.39); Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (424 aa)
rpl10erpl10E ribosomal protein L10; Belongs to the universal ribosomal protein uL16 family. (181 aa)
topAtopA DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] (685 aa)
rps6erps6E SSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa)
rpl44erpl44E LSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa)
rpl12rpl12A LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (107 aa)
rpl10rpl10E LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (341 aa)
rpl1LSU ribosomal protein L1P (rpl1P); Binds directly to 23S rRNA. Probably involved in E site tRNA release. (219 aa)
polIpolI DNA polymerase I. (771 aa)
PAB0838Hypothetical protein, contains helix-turn-helix motif. (271 aa)
rad32Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (423 aa)
rps8Erps8E SSU ribosomal protein S8E. (127 aa)
PAB0737Hypothetical protein, containing vinyl 4 reductase domain. (399 aa)
rpl21Erpl21E LSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa)
PAB0642recA family AAA ATPase. (240 aa)
rpl15Erpl15E LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa)
obg-likeGTP-binding protein, putative. (357 aa)
rps10Prps10P SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpl7AErpl7AE LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (128 aa)
rps7Prps7P SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
rps12Prps12P SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
PAB0418Hypothetical protein; Belongs to the SDO1/SBDS family. (236 aa)
top6BTop6B DNA topoisomerase VI, subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (564 aa)
PAB0406Predicted RNA-binding protein. (221 aa)
rps2Prps2P SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (202 aa)
rps9Prps9P SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa)
rpl13Prpl13P LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpl18Erpl18E LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (120 aa)
rps11Prps11P SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (137 aa)
rps4Prps4P SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rps13Prps13P SSU ribosomal protein S13P/S18E; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (148 aa)
PAB0329Glutamyl tRNA (GLN) amidotransferase, putative; Belongs to the UPF0145 family. (117 aa)
dnaGPrimase dnaG-like; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (447 aa)
rps3AErps3AE SSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa)
PAB0258Hypothetical protein. (110 aa)
PAB0176Protein involved in ribosomal biogenesis. (166 aa)
PAB0113recA superfamily ATPase implicated in signal transduction. (251 aa)
PAB0112recA superfamily ATPase implicated in signal transduction. (251 aa)
rfcLrfcL activator 1, replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-independent ATPase activity; Belongs to the activator 1 small subunits family. RfcL subfamily. (479 aa)
rfcSrfcS intein containing activator 1, replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-independent ATPase activity; Belongs to the activator 1 small subunits family. RfcS subfamily. (1437 aa)
rpl24Erpl24E LSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa)
rpl29rpl29P LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (60 aa)
rps27erps27E SSU ribosomal protein S27E. (65 aa)
rplXArplXA LSU ribosomal protein LXA. (77 aa)
rpl31Erpl31E LSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (94 aa)
rpl14Erpl14E LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (82 aa)
rpL34Erpl34E LSU ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (91 aa)
nop10Small nucleolar ribonucleoprotein, trans-acting factor intervening in ribosome biogenesis; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (60 aa)
rpl40Erpl40E LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa)
rps17erps17E SSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa)
rps28Erps28E SSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (71 aa)
rpl37Erpl37E LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (62 aa)
rpl30Erpl30E LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
albAConserved hypothetical protein, DUF78 family; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (93 aa)
rpl35aerpl35AE LSU ribosomal protein L35AE; Belongs to the eukaryotic ribosomal protein eL33 family. (87 aa)
rpl23rpl23P LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rps14rps14P SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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