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guaA guaA ureB ureB ureA ureA purA purA adk-2 adk-2 cpdB cpdB RSP_0782 RSP_0782 RSP_0955 RSP_0955 ade ade purH purH ham1 ham1 amn amn RSP_1552 RSP_1552 RSP_1553 RSP_1553 RSP_1555 RSP_1555 purK purK purE purE sopT sopT deoB deoB add add RSP_1621 RSP_1621 spoT/relA spoT/relA adk adk pykA pykA apt apt PurD PurD RSP_1848 RSP_1848 RSP_1896 RSP_1896 purM purM purN purN purC purC purS purS purQ purQ deoD deoD purB purB purC1 purC1 prsA prsA gpt gpt purF purF nrd nrd surE surE dgt dgt RSP_2771 RSP_2771 HPRT HPRT guaB guaB pgm pgm ndk ndk RSP_2912 RSP_2912 RSP_2914 RSP_2914 gmk gmk purL purL RSP_3204 RSP_3204 RSP_3205 RSP_3205 RSP_3206 RSP_3206 RSP_3334 RSP_3334 RSP_3547 RSP_3547 xdhA xdhA xdhB xdhB RSP_3644 RSP_3644 ureC ureC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (518 aa)
ureBUrease, beta subunit; IMG reference gene:2512955317; PFAM: Urease beta subunit; TIGRFAM: urease, beta subunit; Belongs to the urease beta subunit family. (101 aa)
ureAUrease, gamma subunit; IMG reference gene:2512955318; PFAM: Urease, gamma subunit; TIGRFAM: urease, gamma subunit; Belongs to the urease gamma subunit family. (100 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
adk-2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (226 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; IMG reference gene:2512955730; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; TIGRFAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (630 aa)
RSP_0782Ppx/GppA phosphatase; IMG reference gene:2512955809; PFAM: Ppx/GppA phosphatase family; TIGRFAM: exopolyphosphatase. (513 aa)
RSP_09555'-nucleotidase; IMG reference gene:2512955991; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. (523 aa)
adeAdenine deaminase; IMG reference gene:2512956023; PFAM: Amidohydrolase family; TIGRFAM: adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (565 aa)
purHIMG reference gene:2512956145; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (529 aa)
ham1dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (203 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (492 aa)
RSP_1552Ureidoglycolate hydrolase; IMG reference gene:2512953448; PFAM: Ureidoglycolate hydrolase. (163 aa)
RSP_1553Putative glyoxylate induced protein; IMG reference gene:2512953449; PFAM: Cupin domain; TIGRFAM: putative allantoin catabolism protein. (278 aa)
RSP_1555Transthyretin-like protein; IMG reference gene:2512953451; PFAM: HIUase/Transthyretin family; TIGRFAM: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (117 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
sopTSulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate. (568 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (398 aa)
addAdenosine deaminase; IMG reference gene:2512953494; PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase. (327 aa)
RSP_1621Deoxyguanosinetriphosphate triphosphohydrolase-like protein; IMG reference gene:2512953521; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative. (487 aa)
spoT/relARelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (705 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
pykAPyruvate kinase; IMG reference gene:2512953671; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (178 aa)
PurDPhosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (420 aa)
RSP_1848Pyruvate kinase; IMG reference gene:2512953757; PFAM: Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family. (508 aa)
RSP_1896Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (428 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2512953883; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase. (348 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa)
purCIMG reference gene:2512954050; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (250 aa)
purSComponent of phosphoribosylformylglycinamidine (FGAM) synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] (79 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa)
deoDPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (266 aa)
purBIMG reference gene:2512954150; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (434 aa)
purC1IMG reference gene:2512954187; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (319 aa)
prsAPhosphoribosyl pyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (487 aa)
nrdRibonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1218 aa)
surE5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa)
dgtIMG reference gene:2512954604; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (378 aa)
RSP_2771Putative Exopolyphosphatase; IMG reference gene:2512954721; PFAM: Ppx/GppA phosphatase family. (378 aa)
HPRTHypoxanthine-guanine phosphoribosyltransferase; IMG reference gene:2512954736; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (482 aa)
pgmPhosphoglucomutase; IMG reference gene:2512954845; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I. (544 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
RSP_2912Putative pyrophosphatase; IMG reference gene:2512954874; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein. (268 aa)
RSP_2914Nucleoside hydrolase; IMG reference gene:2512954876; PFAM: Inosine-uridine preferring nucleoside hydrolase. (313 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (720 aa)
RSP_3204Putative Oxidoreductase; IMG reference gene:2512956716; PFAM: 2Fe-2S iron-sulfur cluster binding domain; [2Fe-2S] binding domain. (173 aa)
RSP_3205Putative oxidoreductase subunit; IMG reference gene:2512956717; PFAM: FAD binding domain in molybdopterin dehydrogenase; CO dehydrogenase flavoprotein C-terminal domain. (327 aa)
RSP_3206Xanthine dehydrogenase, molybdenum binding subunit apoprotein; IMG reference gene:2512956718; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. (739 aa)
RSP_3334HyuE hydantoin racemase; IMG reference gene:2512956843; PFAM: Asp/Glu/Hydantoin racemase; extended by 13 aa. (218 aa)
RSP_3547Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (755 aa)
xdhAXanthine dehydrogenase, small subunit; IMG reference gene:2512957064; PFAM: 2Fe-2S iron-sulfur cluster binding domain; FAD binding domain in molybdopterin dehydrogenase; [2Fe-2S] binding domain; CO dehydrogenase flavoprotein C-terminal domain; TIGRFAM: xanthine dehydrogenase, small subunit. (485 aa)
xdhBXanthine dehydrogenase, large subunit; IMG reference gene:2512957065; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. (825 aa)
RSP_3644Metal dependent phosphohydrolase; IMG reference gene:2512957178; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (473 aa)
ureCIMG reference gene:2512955314; PFAM: Urease alpha-subunit, N-terminal domain; Amidohydrolase family; TIGRFAM: urease, alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (568 aa)
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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