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moaA moaA folA folA mobA mobA ribBA ribBA RSP_0816 RSP_0816 RSP_0817 RSP_0817 ribA ribA DCOHM DCOHM folC folC moaE moaE FolK FolK mogA mogA folE2 folE2 RSP_1861 RSP_1861 RSP_1862 RSP_1862 RSP_1936 RSP_1936 RSP_1998 RSP_1998 moaC moaC moeA moeA moaA-2 moaA-2 exsB exsB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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moaACyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (344 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
mobAMolybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (193 aa)
ribBABifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (367 aa)
RSP_0816IMG reference gene:2512955844; PFAM: Aminotransferase class IV; extended by 19 aa. (213 aa)
RSP_0817Aminodeoxychorismate synthase, subunit I; IMG reference gene:2512955845; PFAM: chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade; truncated by 9 aa. (381 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (362 aa)
DCOHMPterin dehydratase; IMG reference gene:2512955930; PFAM: Pterin 4 alpha carbinolamine dehydratase. (92 aa)
folCFolylpolyglutamate synthetase; IMG reference gene:2512955963; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (424 aa)
moaEMolybdopterin converting factor subunit 2; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family. (146 aa)
FolKIMG reference gene:2512953572; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (178 aa)
mogAIMG reference gene:2512953731; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (181 aa)
folE2GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. (359 aa)
RSP_1861IMG reference gene:2512953770; PFAM: Dihydroneopterin aldolase; TIGRFAM: dihydroneopterin aldolase; FolB domain. (300 aa)
RSP_1862Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (345 aa)
RSP_1936Molybdopterin biosynthesis protein; IMG reference gene:2512953849. (334 aa)
RSP_1998Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (394 aa)
moaCCyclic pyranopterin monophosphate synthase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (159 aa)
moeAMolybdenum cofactor biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (410 aa)
moaA-2Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (338 aa)
exsBpreQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (207 aa)
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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