STRINGSTRING
RP609 RP609 RP057 RP057 RP063 RP063 RP067 RP067 RP070 RP070 RP102 RP102 RP117 RP117 RP118 RP118 RP121 RP121 RP154 RP154 RP160 RP160 RP163 RP163 RP168 RP168 RP171 RP171 RP183 RP183 RP200 RP200 RP201 RP201 RP206 RP206 RP227 RP227 RP247 RP247 RP248 RP248 RP249 RP249 RP250 RP250 RP258 RP258 RP263 RP263 RP268 RP268 RP274 RP274 RP280 RP280 RP304 RP304 RP320 RP320 RP322 RP322 RP323 RP323 RP326 RP326 RP330 RP330 RP348 RP348 RP385 RP385 RP386 RP386 RP389 RP389 RP390 RP390 RP410 RP410 RP411 RP411 RP412 RP412 RP435 RP435 RP447 RP447 RP484 RP484 RP485 RP485 RP486 RP486 RP524 RP524 RP529 RP529 RP536 RP536 RP540 RP540 RP542 RP542 RP544 RP544 RP545 RP545 RP554 RP554 RP555 RP555 RP565 RP565 RP569 RP569 RP579 RP579 RP580 RP580 RP588 RP588 RP590 RP590 RP593 RP593 RP595 RP595 RP596 RP596 RP597 RP597 RP598 RP598 RP628 RP628 RP666 RP666 RP667 RP667 RP672 RP672 RP674 RP674 RP677 RP677 RP703 RP703 RP725 RP725 RP734 RP734 RP741 RP741 RP747 RP747 RP794 RP794 RP807 RP807 RP811 RP811 RP830 RP830 RP843 RP843 RP846 RP846
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RP609CYANELLE 50S RIBOSOMAL PROTEIN L20 (rplT); Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (117 aa)
RP057GLUCOSE INHIBITED DIVISION PROTEIN B (gidB); Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (191 aa)
RP063HESB PROTEIN (hesB1); Belongs to the HesB/IscA family. (110 aa)
RP067TOPOISOMERASE IV SUBUNIT A (parC); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (738 aa)
RP070PROTEIN-EXPORT PROTEIN SECB (secB); One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (152 aa)
RP102Unknown; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (214 aa)
RP117RIBONUCLEASE III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (225 aa)
RP118GTP-BINDING PROTEIN ERA (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (295 aa)
RP121Unknown; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (318 aa)
RP154RIBOSOME RECYCLING FACTOR (rrf); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (186 aa)
RP160OUTER MEMBRANE PROTEIN OMP1 (omp1); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (768 aa)
RP163CELL DIVISION PROTEIN FTSJ (ftsJ); Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (227 aa)
RP168Unknown; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity). (198 aa)
RP171DNA-BINDING PROTEIN HU (hupA); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (110 aa)
RP183Unknown; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (251 aa)
RP200HEAT SHOCK PROTEIN HSCA (hscA); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity). (593 aa)
RP201Unknown; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (139 aa)
RP206DNA GYRASE SUBUNIT A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (905 aa)
RP227DNA GYRASE SUBUNIT B (gyrB1); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (662 aa)
RP247UDP-N-ACETYLMURAMATE--ALANINE LIGASE (murC); Cell wall formation; Belongs to the MurCDEF family. (495 aa)
RP248UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE (murB); Cell wall formation. (310 aa)
RP249D-ALANINE--D-ALANINE LIGASE (ddlB); Cell wall formation. (321 aa)
RP250CELL DIVISION PROTEIN FTSQ (ftsQ); Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (267 aa)
RP258Unknown; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family. (303 aa)
RP263Unknown. (605 aa)
RP268HAEM EXPORTER PROTEIN B (ccmB). (215 aa)
RP274PEPTIDE CHAIN RELEASE FACTOR 2 (prfB); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (369 aa)
RP280ROD SHAPE-DETERMINING PROTEIN RODA (rodA); Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (383 aa)
RP304CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11 (cox11); Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I; Belongs to the COX11/CtaG family. (178 aa)
RP320HEAT SHOCK PROTEIN HSLU (hslU); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (450 aa)
RP322Unknown; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (340 aa)
RP323CYAY PROTEIN (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (104 aa)
RP326DNA TOPOISOMERASE I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] (776 aa)
RP330Unknown; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (156 aa)
RP348Unknown; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (165 aa)
RP385HOLLIDAY JUNCTION DNA HELICASE RUVA (ruvA); The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
RP386HOLLIDAY JUNCTION DNA HELICASE RUVB (ruvB); The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. Belongs to the RuvB family. (342 aa)
RP389PENICILLIN-BINDING PROTEIN DACF PRECURSOR (dacF); Belongs to the peptidase S11 family. (306 aa)
RP390RARE LIPOPROTEIN A PRECURSOR (rlpA); Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (320 aa)
RP410UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE (murD); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (445 aa)
RP411CELL DIVISION PROTEIN FTSW (ftsW); Belongs to the SEDS family. (377 aa)
RP412MURG PROTEIN (murG); Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (385 aa)
RP435RIBOSOME-BINDING FACTOR A (rbfA); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (128 aa)
RP447DNA HELICASE II (uvrD); Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity); Belongs to the helicase family. UvrD subfamily. (658 aa)
RP484HESB PROTEIN (hesB2); Belongs to the HesB/IscA family. (110 aa)
RP485NIFU PROTEIN (nifU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Belongs to the NifU family. (131 aa)
RP486NIFS PROTEIN HOMOLOG (spl1); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (410 aa)
RP524Unknown; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (80 aa)
RP529PEPTIDE CHAIN RELEASE FACTOR 1 (prfA); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa)
RP536FOLYLPOLYGLUTAMATE SYNTHASE (folC); Belongs to the folylpolyglutamate synthase family. (433 aa)
RP540POSSIBLE PRIMOSOMAL PROTEIN N (priA); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (648 aa)
RP542PROBABLE REPLICATIVE DNA HELICASE (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (486 aa)
RP544Unknown. (235 aa)
RP545Unknown. (236 aa)
RP554Unknown; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (117 aa)
RP555HEMOLYSIN (tlyA). (251 aa)
RP565PENICILLIN-BINDING PROTEIN (pbpA1). (594 aa)
RP569Unknown; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (306 aa)
RP579UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE (murA); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
RP580DNA GYRASE SUBUNIT B (gyrB2); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (807 aa)
RP588CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCME (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (128 aa)
RP590VIRULENCE FACTOR MVIN (mviN); Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (507 aa)
RP593ATP-DEPENDENT DNA HELICASE RECG (recG). (724 aa)
RP595PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE- TRANSFERASE (mraY1); First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
RP596UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2, 6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE (murF); Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (449 aa)
RP597UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2, 6-DIAMINOPIMELATE LIGASE (murE); Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (480 aa)
RP598TRANSCRIPTION-REPAIR COUPLING FACTOR (mfd); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the N-terminal section; belongs to the UvrB family. (1120 aa)
RP628RIBONUCLEASE PH (rph); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (240 aa)
RP666CELL DIVISION PROTEIN FTSZ (ftsZ); Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (452 aa)
RP667Unknown. (190 aa)
RP672DIMETHYLADENOSINE TRANSFERASE (ksgA); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (268 aa)
RP674Unknown; Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane; Belongs to the LptD family. (711 aa)
RP677Unknown; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (447 aa)
RP703CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF (ccmF). (670 aa)
RP725Unknown. (100 aa)
RP734ATP-DEPENDENT NUCLEASE SUBUNIT A (addA). (822 aa)
RP741Unknown; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (180 aa)
RP747Unknown; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (280 aa)
RP794HEME EXPORTER PROTEIN A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (197 aa)
RP807PENICILLIN-BINDING PROTEIN 1A (mrcA); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (787 aa)
RP811Unknown; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (108 aa)
RP830HEME EXPORTER PROTEIN C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (230 aa)
RP843Unknown; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (331 aa)
RP846SFHB PROTEIN HOMOLOG (sfhB); Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (313 aa)
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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