STRINGSTRING
RP044 RP044 RP055 RP055 RP091 RP091 RP126 RP126 RP127 RP127 RP128 RP128 RP148 RP148 RP179 RP179 RP180 RP180 RP190 RP190 RP220 RP220 RP239 RP239 RP241 RP241 RP242 RP242 RP257 RP257 RP261 RP261 RP262 RP262 RP265 RP265 RP299 RP299 RP316 RP316 RP325 RP325 RP332 RP332 RP346 RP346 RP365 RP365 RP376 RP376 RP415 RP415 RP424 RP424 RP425 RP425 RP428 RP428 RP429 RP429 RP432 RP432 RP433 RP433 RP442 RP442 RP449 RP449 RP452 RP452 RP460 RP460 RP466 RP466 RP469 RP469 RP479 RP479 RP492 RP492 RP509 RP509 RP510 RP510 RP530 RP530 RP539 RP539 RP541 RP541 RP560 RP560 RP561 RP561 RP618 RP618 RP619 RP619 RP622 RP622 RP623 RP623 RP638 RP638 RP665 RP665 RP680 RP680 RP686 RP686 RP706 RP706 RP735 RP735 RP737 RP737 RP743 RP743 RP753 RP753 RP762 RP762 RP763 RP763 RP799 RP799 RP805 RP805 RP819 RP819 RP821 RP821 RP841 RP841 RP844 RP844 RP882 RP882 RP883 RP883 RP884 RP884 RP885 RP885
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RP044SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (261 aa)
RP055NUCLEOSIDE DIPHOSPHATE KINASE (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
RP091ASPARTATE AMINOTRANSFERASE A (aatA); Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (412 aa)
RP126SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT (sdhC); Membrane-anchoring subunit of succinate dehydrogenase (SDH). (124 aa)
RP127SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN (sdhD); Membrane-anchoring subunit of succinate dehydrogenase (SDH). (125 aa)
RP128SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT (sdhA). (596 aa)
RP148DIHYDRODIPICOLINATE REDUCTASE (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (239 aa)
RP179DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT (sucB); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (401 aa)
RP1802-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT (sucA); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (936 aa)
RP190UBIQUINONE BIOSYNTHESIS PROTEIN COQ7 (coq7); Belongs to the COQ7 family. (178 aa)
RP220PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (purC); Belongs to the SAICAR synthetase family. (236 aa)
RP239EXTRAGENIC SUPPRESSOR PROTEIN SUHB (suhB). (245 aa)
RP241Unknown; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (231 aa)
RP242CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE (pssA); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (224 aa)
RP257CYTOCHROME C OXIDASE ASSEMBLY PROTEI (coxW); Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (334 aa)
RP261PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT PRECURSOR (pdhA); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (326 aa)
RP262PYRUVATE DEHYDROGENASE E1 COMPONENT, BETA SUBUNIT PRECURSOR (pdhB); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (326 aa)
RP265ISOCITRATE DEHYDROGENASE (icd); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (483 aa)
RP299GALACTOSE-6-PHOSPHATE ISOMERASE LACB SUBUNIT (lacA); Belongs to the LacAB/RpiB family. (144 aa)
RP316ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
RP325GLUTAMYL-TRNA SYNTHETASE (gltX1); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (447 aa)
RP332Unknown; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (284 aa)
RP346CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (310 aa)
RP365PUTATIVE ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (fabI); Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (261 aa)
RP376MALATE DEHYDROGENASE (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa)
RP415DIAMINOPIMELATE EPIMERASE (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (270 aa)
RP424PHOSPHATIDATE CYTIDYLYLTRANSFERASE (cdsA). (228 aa)
RP425Unknown; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (226 aa)
RP428BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE (ilvE); Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa)
RP429DIHYDRODIPICOLINATE SYNTHASE (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
RP432SUCCINYL-COA LIGASE (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
RP433SUCCINYL-COA SYNTHETASE BETA CHAIN (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
RP442GLYCEROL-3-PHOSPHATE DEHYDROGENASE (gpsA); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (316 aa)
RP449THREONINE DEHYDRATASE (tdcB). (333 aa)
RP452Unknown; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (342 aa)
RP460DIHYDROLIPOAMIDE DEHYDROGENASE PRECURSOR (pdhD). (453 aa)
RP466PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (299 aa)
RP469POSSIBLE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (plsC). (243 aa)
RP479OCTAPRENYL-DIPHOSPHATE SYNTHASE (ispB); Belongs to the FPP/GGPP synthase family. (327 aa)
RP492PYRUVATE,PHOSPHATE DIKINASE PRECURSOR (ppdK); Catalyzes the reversible phosphorylation of pyruvate and phosphate; Belongs to the PEP-utilizing enzyme family. (880 aa)
RP509PHOSPHOMANNOMUTASE (exoC). (508 aa)
RP510TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE (miaA); Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (311 aa)
RP530DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT (pdhC); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (408 aa)
RP539DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. (330 aa)
RP5413-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE (ubiX); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa)
RP560PROBABLE 3-HYDROXYACYL-COA DEHYDROGENASE B0272.3 (fadB); In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (720 aa)
RP561Unknown. (302 aa)
RP618PROPIONYL-COA CARBOXYLASE ALPHA CHAIN PRECURSOR (pccA). (665 aa)
RP619PROPIONYL-COA CARBOXYLASE BETA CHAIN PRECURSOR (pccB). (514 aa)
RP6223-DEMETHYLUBIQUINONE-9 3-METHYLTRANSFERASE (ubiG); O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (252 aa)
RP623GLUTAMYL-TRNA SYNTHETASE (gltX2); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (470 aa)
RP638ADENYLATE KINASE (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (213 aa)
RP665FUMARATE HYDRATASE (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
RP680UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHLYTRANSFERASE UBIE (ubiE); Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (265 aa)
RP6864-HYDROXYBENZOATE OCTAPRENYLTRANSFERASE (ubiA); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (282 aa)
RP706Unknown. (314 aa)
RP735MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (fabD). (319 aa)
RP737ACETYL-COA ACETYLTRANSFERASE (fadA); Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
RP743SERINE HYDROXYMETHYLTRANSFERASE (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
RP753ASPARTOKINASE (lysC); Belongs to the aspartokinase family. (446 aa)
RP7623-OXOACYL REDUCTASE (fabG); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (241 aa)
RP763ACYL CARRIER PROTEIN (acpP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (86 aa)
RP799ACONITATE HYDRATASE (acnA); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. (878 aa)
RP805DIHYDROLIPOAMIDE DEHYDROGENASE (pdhD). (459 aa)
RP819Unknown; Could be a virulence factor; Belongs to the phospholipase D family. (205 aa)
RP821Unknown; Belongs to the UbiD family. (492 aa)
RP8415-AMINOLEVULINIC ACID SYNTHASE (hemA); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (414 aa)
RP844CITRATE SYNTHASE (gltA). (436 aa)
RP882COPROPORPHYRINOGEN III OXIDASE PRECURSOR (hemF); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (279 aa)
RP883Unknown; Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX. Is involved in the biosynthesis of tetrapyrrole molecules like heme. Does not use oxygen or artificial electron acceptors such as menadione or benzoquinone. Belongs to the HemJ family. (145 aa)
RP884PROBABLE FERROCHELATASE (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (346 aa)
RP885UROPORPHYRINOGEN DECARBOXYLASE (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (345 aa)
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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