(11 nodes) Ligase activity, forming carbon-nitrogen bonds network (Spiroplasma kunkelii)

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	nadE	NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (249 aa)
	fhs	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (535 aa)
	guaA	GMP synthase; Catalyzes the synthesis of GMP from XMP. (512 aa)
	purA	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (433 aa)
	pyrG	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)
	asnA	Asparagine synthetase AsnA. (334 aa)
	folC	Folylpolyglutamate synthase. (374 aa)
	gatB	aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (480 aa)
	pncB	Nicotinate phosphoribosyltransferase; Belongs to the NAPRTase family. (341 aa)
	mesJ	tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (435 aa)
	ALA97041.1	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (160 aa)

Your Current Organism:

Spiroplasma kunkelii

NCBI taxonomy Id: 273035
Other names: S. kunkelii CR2-3x, Spiroplasma kunkelii CR2-3x, Spiroplasma kunkelii str. CR2-3x, Spiroplasma kunkelii strain CR2-3x

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALA97041.1	fhs	SKUN_00117	SKUN_00708	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.409
asnA	purA	SKUN_001697	SKUN_00195	Asparagine synthetase AsnA.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.902
fhs	ALA97041.1	SKUN_00708	SKUN_00117	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.409
fhs	folC	SKUN_00708	SKUN_00152	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Folylpolyglutamate synthase.	0.687
fhs	guaA	SKUN_00708	SKUN_00300	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.589
folC	fhs	SKUN_00152	SKUN_00708	Folylpolyglutamate synthase.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.687
folC	guaA	SKUN_00152	SKUN_00300	Folylpolyglutamate synthase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.532
gatB	guaA	SKUN_001481	SKUN_00300	aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.675
guaA	fhs	SKUN_00300	SKUN_00708	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.589
guaA	folC	SKUN_00300	SKUN_00152	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Folylpolyglutamate synthase.	0.532
guaA	gatB	SKUN_00300	SKUN_001481	GMP synthase; Catalyzes the synthesis of GMP from XMP.	aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	0.675
guaA	mesJ	SKUN_00300	SKUN_0012	GMP synthase; Catalyzes the synthesis of GMP from XMP.	tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.	0.458
guaA	nadE	SKUN_00300	SKUN_001195	GMP synthase; Catalyzes the synthesis of GMP from XMP.	NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.	0.517
guaA	pncB	SKUN_00300	SKUN_001444	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Nicotinate phosphoribosyltransferase; Belongs to the NAPRTase family.	0.444
guaA	purA	SKUN_00300	SKUN_00195	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.683
guaA	pyrG	SKUN_00300	SKUN_00194	GMP synthase; Catalyzes the synthesis of GMP from XMP.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.958
mesJ	guaA	SKUN_0012	SKUN_00300	tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.458
nadE	guaA	SKUN_001195	SKUN_00300	NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.517
nadE	pncB	SKUN_001195	SKUN_001444	NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.	Nicotinate phosphoribosyltransferase; Belongs to the NAPRTase family.	0.492
pncB	guaA	SKUN_001444	SKUN_00300	Nicotinate phosphoribosyltransferase; Belongs to the NAPRTase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.444