STRINGSTRING
fib fib nfo nfo rplL rplL dck dck rplJ rplJ yqeH yqeH rpsO rpsO ALA97605.1 ALA97605.1 fhs fhs ALA97594.1 ALA97594.1 ybeY ybeY rplT rplT rpmI rpmI SKUN_0069 SKUN_0069 rpsB rpsB rnmV rnmV comEB comEB rpmF rpmF tadA tadA rplU rplU SKUN_0055 SKUN_0055 ALA97437.1 ALA97437.1 hupB hupB ALA97308.1 ALA97308.1 rpsD rpsD rpmB rpmB ALA97287.1 ALA97287.1 ALA97275.1 ALA97275.1 ALA97273.1 ALA97273.1 SKUN_0032 SKUN_0032 ALA97215.1 ALA97215.1 ALA97214.1 ALA97214.1 rplS rplS rpsP rpsP rplQ rplQ ALA98388.1 ALA98388.1 rpsK rpsK rpsM rpsM adk adk rplO rplO rpsE rpsE rplR rplR rplF rplF rpsH rpsH crr crr ALA98204.1 ALA98204.1 ALA98197.1 ALA98197.1 pgk pgk ALA98189.1 ALA98189.1 yrvN yrvN ALA98163.1 ALA98163.1 ALA98161.1 ALA98161.1 ALA98144.1 ALA98144.1 yrrK yrrK rplA rplA rplK rplK sufB sufB xseA xseA sufD sufD pfs pfs ALA97933.1 ALA97933.1 rpsI rpsI recO recO dnaG dnaG rplM rplM ALA97176.1 ALA97176.1 rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ dnaC dnaC truA truA ALA97143.1 ALA97143.1 topA topA ALA97114.1 ALA97114.1 engD engD rpsF rpsF rpsR rpsR ALA97092.1 ALA97092.1 ALA98535.1 ALA98535.1 rpmE rpmE ALA98510.1 ALA98510.1 rpsL rpsL rpsG rpsG dnaI dnaI rpsT rpsT dam dam dnaBs dnaBs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fibFibril protein. (501 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (308 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa)
dckDeoxyadenosine/deoxycytidine kinase. (204 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa)
yqeHGTP-binding protein YqeH. (358 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (88 aa)
ALA97605.1Bifunctional riboflavin kinase/FAD synthetase; Belongs to the ribF family. (295 aa)
fhsFormate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (535 aa)
ALA97594.1Diacylglycerol kinase. (142 aa)
ybeYHypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (158 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
SKUN_00694-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Belongs to the GHMP kinase family. IspE subfamily. (248 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (365 aa)
rnmVPrimase-like protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (172 aa)
comEBDeoxycytidylate deaminase. (166 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa)
tadAtRNA-specific adenosine deaminase. (159 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (173 aa)
SKUN_0055DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. (264 aa)
ALA97437.1Putative MoxR-like ATPase. (513 aa)
hupBDNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. (94 aa)
ALA97308.1Hypothetical protein. (571 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (65 aa)
ALA97287.150S ribosomal protein L7Ae. (103 aa)
ALA97275.1Cysteine methyltransferase. (77 aa)
ALA97273.1PTS system IIBC component. (121 aa)
SKUN_0032DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. (265 aa)
ALA97215.1Putative GTPase; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (296 aa)
ALA97214.1Ribosome biogenesis GTPase. (127 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (118 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (119 aa)
rplQ50S ribosomal protein L17. (119 aa)
ALA98388.1HNH endonuclease, putative. (134 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (145 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (204 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (128 aa)
crrPTS system glucose-specific IIA component. (160 aa)
ALA98204.1Deoxynucleoside kinase. (176 aa)
ALA98197.1Deoxynucleoside kinase. (202 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
ALA98189.1DNA methylase. (60 aa)
yrvNRecombination factor protein RarA. (414 aa)
ALA98163.1Hypothetical protein. (117 aa)
ALA98161.1Hypothetical protein. (125 aa)
ALA98144.1Spiroplasmavirus-related protein. (359 aa)
yrrKHolliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (139 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (228 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa)
sufBFeS assembly protein SufB. (470 aa)
xseAPutative exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (430 aa)
sufDABC-type iron-sulfur cluster assembly transport system permease protein. (276 aa)
pfs5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (226 aa)
ALA97933.1DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. (257 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (133 aa)
recODNA repair protein recO. (94 aa)
dnaGPutative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (626 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (146 aa)
ALA97176.130S ribosomal protein S14. (62 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (106 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (336 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (252 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (112 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (208 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (258 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (110 aa)
dnaCReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (458 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (260 aa)
ALA97143.1Hypothetical protein. (107 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (664 aa)
ALA97114.1Hypothetical protein. (409 aa)
engDGTP-dependent nucleic acid-binding protein EngD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (149 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (74 aa)
ALA97092.1Hypothetical protein. (219 aa)
ALA98535.1DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. (242 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (101 aa)
ALA98510.1DHH family protein. (320 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (140 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa)
dnaIPrimosomal protein DnaI. (306 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (83 aa)
damAdenine-specific DNA-methyltransferase; Belongs to the N(4)/N(6)-methyltransferase family. (243 aa)
dnaBsChromosome replication initiation/membrane attachment protein. (415 aa)
Your Current Organism:
Spiroplasma kunkelii
NCBI taxonomy Id: 273035
Other names: S. kunkelii CR2-3x, Spiroplasma kunkelii CR2-3x, Spiroplasma kunkelii str. CR2-3x, Spiroplasma kunkelii strain CR2-3x
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