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purT purT upP upP SSO0233 SSO0233 SSO0234 SSO0234 purB purB purA purA glmS-1 glmS-1 SSO0432 SSO0432 SSO0606 SSO0606 SSO0607 SSO0607 SSO0608 SSO0608 SSO0609 SSO0609 pyrD pyrD pyrC pyrC SSO0612 SSO0612 pyrI pyrI pyrB pyrB pyrE pyrE pyrF pyrF SSO0617 SSO0617 purC purC purQ purQ purL purL purF-1 purF-1 purF-2 purF-2 purD purD purM purM carA carA carB carB pyrH pyrH purE purE purK purK glmS-2 glmS-2 guaA guaA SSO2865 SSO2865 SSO3218 SSO3218 guaA-2 guaA-2 purS purS
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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purTPhosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa)
upPUracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
SSO0233Conserved hypothetical protein; Seems related to pur operon repressor. Similar to PH1691, PAB2035, APE0060. (246 aa)
SSO0234Hypothetical protein. (180 aa)
purBAdenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa)
purAAdenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa)
glmS-1Glutamine-fructose-6-phosphate transaminase (isomerizing) (glmS-1); Amino Acid Biosynthesis, Glutamate. (591 aa)
SSO0432HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
SSO0606Transcriptional regulator, putative; Belongs to ASNC family; Transcription, RNA polymerase and transcription factors. (157 aa)
SSO0607Conserved hypothetical protein; Similarity with AF2111, MJ1677, PAB0863,aq_540. (202 aa)
SSO0608Conserved hypothetical protein; Some similarity with APE1948. (103 aa)
SSO0609Hypothetical protein. (99 aa)
pyrDDihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa)
pyrCDihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa)
SSO0612Hypothetical protein. (208 aa)
pyrIAspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa)
pyrBAspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa)
pyrEOrotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa)
SSO0617Hypothetical protein. (157 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa)
purQPhosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa)
purLPhosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa)
purF-1Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa)
purF-2Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa)
purDPhosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa)
carACarbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa)
carBCarbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa)
pyrHUridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa)
glmS-2Glutamine-fructose-6-phosphate transaminase (isomerizing) (glmS-2); Amino Acid Biosynthesis, Glutamate. (584 aa)
guaAGMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa)
SSO2865Hypothetical protein. (104 aa)
SSO3218Conserved hypothetical protein. (298 aa)
guaA-2GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa)
purSConserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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