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rpoD rpoD rpoA2 rpoA2 rpoA1 rpoA1 rpoB1 rpoB1 tfE tfE rpoG rpoG SSO0280 SSO0280 rpoM-1 rpoM-1 Dph2 Dph2 SSO0313 SSO0313 SSO0396 SSO0396 rpoE1 rpoE1 TFB-1 TFB-1 SSO0473 SSO0473 SSO0475 SSO0475 SSO0605 SSO0605 rpoF rpoF TFB-2 TFB-2 tfIID tfIID SSO0959 SSO0959 SSO1879 SSO1879 rpoB2 rpoB2 rpoN rpoN rpoH rpoH rpoM-like rpoM-like rpoL rpoL rpoP rpoP rpoK rpoK rpoM-2 rpoM-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoDDNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (265 aa)
rpoA2DNA-directed RNA polymerase, subunit A'' (rpoA2); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (395 aa)
rpoA1DNA-directed RNA polymerase, subunit A' (rpoA1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (880 aa)
rpoB1DNA-directed RNA polymerase, subunit B' (rpoB1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (649 aa)
tfETranscription Factor E (TFE), TFIIE alpha subunit homolog (tfE); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and d [...] (178 aa)
rpoGDNA-directed RNA polymerase, subunit G (rpoG); Transcription. (132 aa)
SSO0280Hypothetical protein; Similar to S. shibatae YTF2_SULSH (P46221) protein in TF55 5' region. (170 aa)
rpoM-1DNA-directed RNA polymerase, subunit M (rpoM-1); Possible in-frame shift with SSO5576. Similar to carboxy-end of RPOM_SULAC, but most other thermophilic genes are the same size; Transcription, RNA polymerase and transcription factors; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (114 aa)
Dph2Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (333 aa)
SSO0313DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases. (550 aa)
SSO0396Hypothetical protein. (104 aa)
rpoE1DNA-directed RNA polymerase, subunit E' (rpoE1); Transcription, RNA polymerase and transcription factors. (180 aa)
TFB-1Transcription initiation factor IIB (TFIIB) homolog (TFB-1); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (309 aa)
SSO0473Close hits to probable DNA repair proteins and helicases; Replication and Repair, Helicases. (444 aa)
SSO0475Conserved hypothetical protein; Some homology to B.burgdorferi predicted coding region BB0212. (485 aa)
SSO0605Zn finger protein, hypothetical; Similar to rpoM; Uncategorized. (116 aa)
rpoFDNA-directed RNA polymerase, subunit F (rpoF); Transcription. (113 aa)
TFB-2Transcription initiation factor IIB (TFIIB) homolog (TFB-2); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (293 aa)
tfIIDTATA box binding protein, hypothetical (tfIID); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). (181 aa)
SSO0959DNA repair protein rad25; Replication and Repair, Helicases. (551 aa)
SSO1879ATP-dependent helicase, putative; Contains a DNA/RNA helicase domain (DEAD/DEAH box); Helicases. (665 aa)
rpoB2DNA-directed RNA polymerase, subunit B'' (rpoB2); Transcription, RNA polymerase and transcription factors; Belongs to the RNA polymerase beta chain family. (480 aa)
rpoNDNA-directed RNA polymerase, subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (66 aa)
rpoHDNA-directed RNA polymerase, subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (84 aa)
rpoM-likeDNA-directed RNA polymerase, putative subunit M (rpoM-like); Possible in-frame shift with SSO0291. Similar to amino-end of RPOM_SULAC; Transcription, RNA polymerase and transcription factors. (90 aa)
rpoLDNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (92 aa)
rpoPDNA-directed RNA polymerase, subunit P (rpoP); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (48 aa)
rpoKDNA-directed RNA polymerase subunit K (rpoK); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (95 aa)
rpoM-2DNA-directed RNA polymerase, subunit M (rpoM-2); Transcription, RNA polymerase and transcription factors. (92 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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