Your Input: | |
| | SSO1824 | Conserved hypothetical protein; Similar to SSO3125, SSO0395, SSO8155. (420 aa) |
| | purA | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | purB | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | thiL | Thiamine monophosphate kinase, putative (thiL); Cofactor Biosynthesis, Thiamine. (323 aa) |
| | SSO0233 | Conserved hypothetical protein; Seems related to pur operon repressor. Similar to PH1691, PAB2035, APE0060. (246 aa) |
| | upP | Uracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | SSO0212 | Conserved hypothetical protein; Similarity with MJ0227, MTH743, PAB0313,APE1715, PH1702. (298 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa) |
| | SSO0197 | Conserved hypothetical protein; Similarity with APE1602,AF2426, MJ1073, PAB1013, PH0512. (287 aa) |
| | dcD-1 | Deoxycytidine triphosphate deaminase (dcD-1); Catalyzes the deamination of dCTP to dUTP. (206 aa) |
| | argB | Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | SSO0149 | Conserved hypothetical protein; Archaeal ORF. (262 aa) |
| | gspE-1 | Type II secretion system protein, virB homolog (gspE-1); Transport, Cell membrane transport. (483 aa) |
| | SSO0115 | Hypothetical protein. (194 aa) |
| | cinA | Competence damage protein (cinA); Regulation; Belongs to the CinA family. (272 aa) |
| | SSO0095 | Conserved hypothetical protein; First part 5S rRNA second part probably unidentified r protein. (399 aa) |
| | SSO0094 | Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (228 aa) |
| | hit | HIT-like protein, hypothetical (hit); HIT family hydrolase; Central Intermediary Metabolism. (171 aa) |
| | SSO0064 | Conserved hypothetical protein. (241 aa) |
| | gdS-1 | Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family. (332 aa) |
| | SSO0039 | Conserved hypothetical protein. (190 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | moaB | Cofactor Biosynthesis, Molybdopterin. (182 aa) |
| | rbsK-1 | Ribokinase (rbsK-1); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa) |
| | cyaB | Adenylate cyclase, cyaB-type, putative (cyaB); Cellular Processes, Purines. (186 aa) |
| | SSO0255 | Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides. (117 aa) |
| | SSO0259 | Conserved hypothetical protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (255 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | aroK | Conserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa) |
| | thyX | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (260 aa) |
| | SSO0330 | Conserved hypothetical protein. (344 aa) |
| | thiI | Thiamine biosynthesis protein thiI (thiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (371 aa) |
| | SSO0354 | Nicotinic acid phosphoribosyltransferase, putative; Cofactor Biosynthesis, Pyridine nucleotides. (387 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (308 aa) |
| | folE | GTP cyclohydrolase I (folE); Purines. (208 aa) |
| | SSO0370 | Conserved hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (292 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | SSO0416 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa) |
| | apgM | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa) |
| | SSO0429 | Hypothetical protein. (326 aa) |
| | SSO0432 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa) |
| | SSO0433 | O-sialoglycoprotein endopeptidase; Protein modification. (223 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (267 aa) |
| | SSO0461 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa) |
| | SSO0468 | Conserved hypothetical protein. (314 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | hmgA | 3 hydroxy 3 methylglutaryl coenzyme a reductase; Converts HMG-CoA to mevalonate; Belongs to the HMG-CoA reductase family. (409 aa) |
| | SSO0535 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putataive (pgsA); Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea. (195 aa) |
| | atpF | ATP synthase subunit F (atpF); Energy Metabolism, ATP-Proton Motive Force. (100 aa) |
| | atpE | ATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | atpA | ATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa) |
| | atpB | ATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | ATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | pdxS | Ethylene-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (338 aa) |
| | pdxT | Glutamine amidotransferase, putative; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa) |
| | ilvB-2 | Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa) |
| | ubiA-2 | 4-hydroxybenzoate octaprenyltransferase, putative (ubiA-2); Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use other prenyl donors, i.e. farnesyl diphosphate (FPP) and phytyl diphosphate. Moreover, 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate, and alpha-glycerophosphate do not function as prenyl acceptor substrates. (282 aa) |
| | SSO0584 | Conserved hypothetical protein. (290 aa) |
| | pyrD | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa) |
| | pyrC | Dihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa) |
| | SSO0612 | Hypothetical protein. (208 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purF-1 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa) |
| | purF-2 | Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa) |
| | SSO0648 | Hypothetical protein. (178 aa) |
| | SSO0666 | Glycerate kinase, putative; Uncategorized. (400 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B (mobB); Cofactor Biosynthesis, Molybdopterin. (169 aa) |
| | moeA-1 | Cofactor Biosynthesis, Molybdopterin. (389 aa) |
| | mobA | Molybdopterin guanine dinucleotide biosynthesis; Cofactor Biosynthesis, Molybdopterin. (194 aa) |
| | cmK | Cytidylate kinase (cmK); Pyrimidines. (189 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | SSO0726 | 2-haloalkanoic acid dehalogenase, putative; Uncategorized. (242 aa) |
| | gldA | Glycerol-1-phosphate dehydrogenase (gldA); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (351 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C (moaC); Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (149 aa) |
| | carS | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (166 aa) |
| | tmK-1 | Thymidylate kinase (tmK-1); Pyrimidines. (189 aa) |
| | SSO0869 | Conserved hypothetical protein; Similarity with SSO1527. (356 aa) |
| | akH | Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa) |
| | ppsA-1 | Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | SSO0886 | Conserved hypothetical protein. (360 aa) |
| | SSO0898 | Conserved hypothetical protein. (331 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa) |
| | SSO0950 | Hypothetical protein. (286 aa) |
| | ribK | Hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa) |
| | pyrH | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa) |
| | rpiA | Ribose 5-phosphate isomerase (rpiA); Energy Metabolism. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | NadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (275 aa) |
| | nadB | Aspartate oxidase (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate. (487 aa) |
| | nadA | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (311 aa) |
| | SSO1038 | Conserved hypothetical protein; Similarity with APE1790, PH1307. (256 aa) |
| | adkA-like | Adenylate kinase related protein (adkA-like); Purines; Belongs to the UPF0200 family. (188 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | porD-2 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa) |
| | acd-1 | Acyl-CoA dehydrogenase (acd-1); Lipid metabolism. (363 aa) |
| | acd-like1 | Acyl-CoA dehydrogenase related protein (acd-like1); Lipid metabolism. (266 aa) |
| | SSO1159 | Haloacetate dehalogenase; Uncategorized. (198 aa) |
| | tmk | Thymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa) |
| | tmK-2 | Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa) |
| | porG-1 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa) |
| | SSO12199 | Conserved hypothetical protein. (83 aa) |
| | acsA-1 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-1); Lipid metabolism. (529 aa) |
| | thiC-1 | Thiamine biosynthesis protein (thiC-1); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | acsA-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa) |
| | acsA-2-2 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa) |
| | pdhA-1 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-1); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (345 aa) |
| | pdhB-1 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-1); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | pdhA-2 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-2); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | pdhB-2 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-2); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (324 aa) |
| | acoX | Acetoin catabolism protein X homolog (acoX); Unknown function in acoXABC operon; Energy Metabolism. (339 aa) |
| | pdhC | Dihydrolipoamide S-acetyltransferase, amino-end (pdhC); Probable frameshift with SSO1530; Energy Metabolism. (211 aa) |
| | pdhC-2 | Dihydrolipoamide S-acetyltransferase, carboxy-end (pdhC); Probable frameshift with SSO1529; Energy Metabolism. (177 aa) |
| | glpK1 | Transporter/facilitator; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (501 aa) |
| | uppP | Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). (278 aa) |
| | SSO1896 | 2-haloalkanoic acid dehalogenase; Uncategorized. (212 aa) |
| | thiC-2 | Thiamine biosynthesis protein (thiC-2); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | acsA-4 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment (acsA-4); Possible frameshift with SSO2021; Lipid metabolism. (288 aa) |
| | acsA-4-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment (acsA-4); Possible frameshift with SSO2020 and SSO9518; Lipid metabolism. (267 aa) |
| | SSO2028 | 2-haloalkanoic acid dehalogenase; Uncategorized. (212 aa) |
| | acsA-6 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa) |
| | acd-3 | Acyl-CoA dehydrogenase (acd-3); Lipid metabolism. (371 aa) |
| | iorB | Indolepyruvate ferredoxin oxidoreductase beta subunit (iorB); Energy Metabolism. (194 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | porD-like | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa) |
| | glpK-2 | Glycerol kinase (glpK-2); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (499 aa) |
| | SSO2151 | Conserved hypothetical protein; Similarity with aq_477. (113 aa) |
| | SSO2157 | Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (233 aa) |
| | SSO2159 | 2-haloalkanoic acid dehalogenase; Uncategorized. (222 aa) |
| | SSO2163 | Histidine triad (Hit) family protein, putative; Uncategorized. (139 aa) |
| | SSO2167 | Conserved hypothetical protein. (166 aa) |
| | SSO2171 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (175 aa) |
| | nadE | NH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa) |
| | SSO2230 | Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (176 aa) |
| | SSO2236 | Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa) |
| | nnrD | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] (501 aa) |
| | MeaB | Conserved hypothetical protein; Putative transport system kinase, argK family protein. (315 aa) |
| | SSO2287 | Probable acyl-coenzyme a thioester hydrolase; Lipid metabolism. (318 aa) |
| | SSO2291 | Protein kinase, putative; Serine/threonine-type; Cellular Processes. (554 aa) |
| | FlaI | Flagella-related protein I, putative (FlaI); Also annotated as: type II secretion system protein (MJ0900); Cellular Processes, Motility. (513 aa) |
| | gpT-1 | Purine phosphoribosyltransferase (gpT-1); Purines. (210 aa) |
| | SSO2348 | Geranylgeranyl hydrogenase, putative; Best hit: AF0464; Lipid metabolism. (332 aa) |
| | SSO2353 | Geranylgeranyl hydrogenase, putative; Lipid metabolism. (398 aa) |
| | nagD-like | Phosphatase, putative (nagD-like); Similarity with nag-operon (glucosamine-6P-conversion; E.coli) nagD gene; Central Intermediary Metabolism. (264 aa) |
| | moeA-2 | Cofactor Biosynthesis, Molybdopterin. (550 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa) |
| | SSO2374 | Conserved hypothetical protein; MJ0444. (254 aa) |
| | gspE-3 | Type II secretion system protein, virB homolog (gspE-3); Protein E of general secretion pathway; type II traffic warden ATPase; Transport, Cell membrane transport. (283 aa) |
| | ppa | Inorganic pyrophosphatase, putative (ppa); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (172 aa) |
| | SSO2391 | Conserved hypothetical protein. (182 aa) |
| | moaE | Cofactor Biosynthesis, Molybdopterin. (231 aa) |
| | SSO2397 | Conserved hypothetical protein. (271 aa) |
| | SSO2399 | Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa) |
| | panB | Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa) |
| | imp3 | Inositol monophosphosphatase, putative (imp3); Similar to MJ0109 with IMPase and fructose-1,6-bisphosphatase activities; Energy Metabolism, Sugar metabolism. (264 aa) |
| | SSO2423 | Conserved hypothetical protein; Similar to TM1581. (389 aa) |
| | gpT-2 | Purine phosphoribosyltransferase (gpT-2); Similar to APE2071 and PAB0060; Purines. (179 aa) |
| | Mce | Lactoylglutathione lyase (glyoxalase I), putative; Energy Metabolism. (142 aa) |
| | rbsK-2 | Ribokinase (rbsK-2); Energy Metabolism. (283 aa) |
| | guaA | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | SSO2453 | Conserved hypothetical protein; Putative protein tyrosine phosphatase (PTPase) (EC 3.1.3.48). Similar to PH1732, PAB0279, DR2161. (161 aa) |
| | acd-like2 | Acyl-CoA dehydrogenase related protein (acd-like2); Lipid metabolism. (299 aa) |
| | nrdB | Ribonucleotide reductase small subunit, probable (nrdB); Purines. (308 aa) |
| | acd-4 | Acyl-CoA dehydrogenase (acd-4); Lipid metabolism. (370 aa) |
| | glpA | Glycerol-3-phosphate dehydrogenase chain A (glpA); Energy Metabolism. (445 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa) |
| | SSO2605 | ABC transporter, ABC1 family, putative; Transport. (496 aa) |
| | SSO2634 | Conserved hypothetical protein. (140 aa) |
| | SSO2635 | Hypothetical protein. (465 aa) |
| | gspE-2 | Type II secretion system protein, virB homolog (gspE-2); Transport, Cell membrane transport. (515 aa) |
| | porG-2 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa) |
| | acd-5 | Acyl-CoA dehydrogenase (acd-5); Lipid metabolism. (398 aa) |
| | SSO2776 | Electron transfert oxidoreductase; Energy Metabolism, Electron transport. (407 aa) |
| | SSO2815 | 2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa) |
| | SSO2816 | 2-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa) |
| | fixC | FIXC protein homolog (fixC); Dehydrogenase (flavoprotein); Energy Metabolism. (395 aa) |
| | ppsA-2 | Phosphoenolpyruvate synthase (ppsA-2); Energy Metabolism, Glycolysis. (312 aa) |
| | fdhD | FDHD protein homolog (fdhD); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (257 aa) |
| | SSO2832 | Conserved hypothetical protein. (233 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | SSO2865 | Hypothetical protein. (104 aa) |
| | acd-6 | Acyl-CoA dehydrogenase (acd-6); Lipid metabolism. (400 aa) |
| | dcD-2 | Deoxycytidine triphosphate deaminase (dcD-2); Pyrimidines. (166 aa) |
| | SSO2988 | (Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa) |
| | MvaD | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. (325 aa) |
| | SSO3125 | Conserved hypothetical protein. (413 aa) |
| | SSO3182 | Serine/threonine protein kinase, putative; Regulation. (635 aa) |
| | kdgK | Fructokinase; Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively. (313 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | SSO3207 | Ser/thr protein kinase, putative; Regulation. (669 aa) |
| | SSO3218 | Conserved hypothetical protein. (298 aa) |
| | SSO3226 | Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa) |
| | guaA-2 | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa) |
| | atpG | ATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | porD-1 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa) |
| | acsA-3-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa) |
