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SSO0666 SSO0666 cmK cmK adkA adkA tmK-1 tmK-1 akH akH ppsA-1 ppsA-1 rbsK-1 rbsK-1 SSO0064 SSO0064 SSO0115 SSO0115 gspE-1 gspE-1 SSO0149 SSO0149 argB argB SSO0197 SSO0197 SSO0212 SSO0212 ndk ndk thiL thiL aroK aroK SSO0370 SSO0370 mvk mvk SSO0416 SSO0416 apgM apgM SSO0433 SSO0433 SSO0461 SSO0461 pgk pgk tmK-2 tmK-2 glpK1 glpK1 glpK-2 glpK-2 nadK nadK SSO2236 SSO2236 MeaB MeaB pyrH pyrH pyK pyK SSO1038 SSO1038 adkA-like adkA-like prs prs tmk tmk SSO2291 SSO2291 FlaI FlaI thrB thrB SSO2374 SSO2374 gspE-3 gspE-3 SSO2397 SSO2397 SSO0950 SSO0950 mptE mptE rbsK-2 rbsK-2 tpiA tpiA SSO2605 SSO2605 SSO2635 SSO2635 gspE-2 gspE-2 ppsA-2 ppsA-2 SSO2988 SSO2988 SSO3182 SSO3182 kdgK kdgK SSO3207 SSO3207 SSO3218 SSO3218 SSO3226 SSO3226 eno eno ribK ribK gap gap
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSO0666Glycerate kinase, putative; Uncategorized. (400 aa)
cmKCytidylate kinase (cmK); Pyrimidines. (189 aa)
adkAAdenylate kinase (adkA); Purines. (195 aa)
tmK-1Thymidylate kinase (tmK-1); Pyrimidines. (189 aa)
akHAspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa)
ppsA-1Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
rbsK-1Ribokinase (rbsK-1); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa)
SSO0064Conserved hypothetical protein. (241 aa)
SSO0115Hypothetical protein. (194 aa)
gspE-1Type II secretion system protein, virB homolog (gspE-1); Transport, Cell membrane transport. (483 aa)
SSO0149Conserved hypothetical protein; Archaeal ORF. (262 aa)
argBAcetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa)
SSO0197Conserved hypothetical protein; Similarity with APE1602,AF2426, MJ1073, PAB1013, PH0512. (287 aa)
SSO0212Conserved hypothetical protein; Similarity with MJ0227, MTH743, PAB0313,APE1715, PH1702. (298 aa)
ndkNucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa)
thiLThiamine monophosphate kinase, putative (thiL); Cofactor Biosynthesis, Thiamine. (323 aa)
aroKConserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa)
SSO0370Conserved hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (292 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa)
SSO0416Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa)
apgMPhosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa)
SSO0433O-sialoglycoprotein endopeptidase; Protein modification. (223 aa)
SSO0461Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa)
pgkPhosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa)
tmK-2Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa)
glpK1Transporter/facilitator; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (501 aa)
glpK-2Glycerol kinase (glpK-2); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (499 aa)
nadKConserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa)
SSO2236Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa)
MeaBConserved hypothetical protein; Putative transport system kinase, argK family protein. (315 aa)
pyrHUridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa)
pyKPyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa)
SSO1038Conserved hypothetical protein; Similarity with APE1790, PH1307. (256 aa)
adkA-likeAdenylate kinase related protein (adkA-like); Purines; Belongs to the UPF0200 family. (188 aa)
prsRibose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa)
tmkThymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa)
SSO2291Protein kinase, putative; Serine/threonine-type; Cellular Processes. (554 aa)
FlaIFlagella-related protein I, putative (FlaI); Also annotated as: type II secretion system protein (MJ0900); Cellular Processes, Motility. (513 aa)
thrBHomoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa)
SSO2374Conserved hypothetical protein; MJ0444. (254 aa)
gspE-3Type II secretion system protein, virB homolog (gspE-3); Protein E of general secretion pathway; type II traffic warden ATPase; Transport, Cell membrane transport. (283 aa)
SSO2397Conserved hypothetical protein. (271 aa)
SSO0950Hypothetical protein. (286 aa)
mptEConserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa)
rbsK-2Ribokinase (rbsK-2); Energy Metabolism. (283 aa)
tpiATriosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa)
SSO2605ABC transporter, ABC1 family, putative; Transport. (496 aa)
SSO2635Hypothetical protein. (465 aa)
gspE-2Type II secretion system protein, virB homolog (gspE-2); Transport, Cell membrane transport. (515 aa)
ppsA-2Phosphoenolpyruvate synthase (ppsA-2); Energy Metabolism, Glycolysis. (312 aa)
SSO2988(Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa)
SSO3182Serine/threonine protein kinase, putative; Regulation. (635 aa)
kdgKFructokinase; Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively. (313 aa)
SSO3207Ser/thr protein kinase, putative; Regulation. (669 aa)
SSO3218Conserved hypothetical protein. (298 aa)
SSO3226Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa)
ribKHypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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