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| | thiD-1 | Phosphomethylpyrimidine kinase (thiD-1); Cofactor Biosynthesis, Thiamine. (400 aa) |
| | rbsK-1 | Ribokinase (rbsK-1); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa) |
| | moaB | Cofactor Biosynthesis, Molybdopterin. (182 aa) |
| | SSO0054 | Conserved hypothetical protein. (179 aa) |
| | gnptA | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (gnptA); Cell Envelope, Surface polysaccharides and lipopolysaccharides. (322 aa) |
| | SSO0064 | Conserved hypothetical protein. (241 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (265 aa) |
| | SSO0076 | Conserved hypothetical protein; Similarity with AF2363, MJ1416, MTH1525. Weakly related to hydrogenase expression/formation protein HypE. (432 aa) |
| | dnaG | Bacterial-like DNA primase (dnaG); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Can use NTPs but not dNTPs. Binds DNA. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine- rich transcripts and the exosome. Belongs to the archaeal DnaG primase family. (406 aa) |
| | dpo3 | DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair. (764 aa) |
| | SSO0086 | Conserved hypothetical protein; APE0213, AF1979, PAB0004, PH0007. (187 aa) |
| | SSO0115 | Hypothetical protein. (194 aa) |
| | SSO0149 | Conserved hypothetical protein; Archaeal ORF. (262 aa) |
| | argB | Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | SSO0197 | Conserved hypothetical protein; Similarity with APE1602,AF2426, MJ1073, PAB1013, PH0512. (287 aa) |
| | SSO0212 | Conserved hypothetical protein; Similarity with MJ0227, MTH743, PAB0313,APE1715, PH1702. (298 aa) |
| | SSO0213 | Conserved hypothetical protein; Similarity with MJ1086. (299 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A'' (rpoA2); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (395 aa) |
| | rpoA1 | DNA-directed RNA polymerase, subunit A' (rpoA1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (880 aa) |
| | rpoB1 | DNA-directed RNA polymerase, subunit B' (rpoB1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (649 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | thiL | Thiamine monophosphate kinase, putative (thiL); Cofactor Biosynthesis, Thiamine. (323 aa) |
| | SSO0255 | Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides. (117 aa) |
| | rpoG | DNA-directed RNA polymerase, subunit G (rpoG); Transcription. (132 aa) |
| | aroK | Conserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa) |
| | SSO0317 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (361 aa) |
| | thiI | Thiamine biosynthesis protein thiI (thiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (371 aa) |
| | SSO0381 | Sugar phosphate nucleotydyl transferase; Several close hits to other proteins; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (363 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | SSO0396 | Hypothetical protein. (104 aa) |
| | rpoE1 | DNA-directed RNA polymerase, subunit E' (rpoE1); Transcription, RNA polymerase and transcription factors. (180 aa) |
| | SSO0416 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa) |
| | SSO0433 | O-sialoglycoprotein endopeptidase; Protein modification. (223 aa) |
| | SSO0461 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | dpo1 | DNA polymerase I (DNA polymerase B1) (dpo1); This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (882 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putataive (pgsA); Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea. (195 aa) |
| | priL | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. (307 aa) |
| | SSO0664 | SUA5 related conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (358 aa) |
| | SSO0666 | Glycerate kinase, putative; Uncategorized. (400 aa) |
| | cmK | Cytidylate kinase (cmK); Pyrimidines. (189 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | SSO0745 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (407 aa) |
| | rpoF | DNA-directed RNA polymerase, subunit F (rpoF); Transcription. (113 aa) |
| | carS | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (166 aa) |
| | SSO0779 | Conserved hypothetical protein. (360 aa) |
| | tmK-1 | Thymidylate kinase (tmK-1); Pyrimidines. (189 aa) |
| | SSO0813 | UTP-glucose-1-phosphate uridylyltransferase; Central Intermediary Metabolism. (246 aa) |
| | SSO0831 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (344 aa) |
| | SSO0869 | Conserved hypothetical protein; Similarity with SSO1527. (356 aa) |
| | akH | Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa) |
| | ppsA-1 | Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | SSO0950 | Hypothetical protein. (286 aa) |
| | ribK | Hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa) |
| | pyrH | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | SSO0989 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (422 aa) |
| | SSO1038 | Conserved hypothetical protein; Similarity with APE1790, PH1307. (256 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (412 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | priS | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] (330 aa) |
| | tmk | Thymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa) |
| | tmK-2 | Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa) |
| | SSO1251 | Conserved hypothetical protein. (113 aa) |
| | dpo2 | DNA polymerase II (DNA polymerase B2) carboxy-end (dpo2); This polymerase is devoid of exonuclease activity; Belongs to the DNA polymerase type-B family. (561 aa) |
| | acoX | Acetoin catabolism protein X homolog (acoX); Unknown function in acoXABC operon; Energy Metabolism. (339 aa) |
| | SSO1570 | Conserved hypothetical protein; Homology with C-term. domain putative sugar isomerase. (127 aa) |
| | glpK1 | Transporter/facilitator; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (501 aa) |
| | SSO1782 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (344 aa) |
| | SSO1835 | Conserved hypothetical protein; Similarity with PH0403, MJ0604. (126 aa) |
| | SSO1884 | Conserved hypothetical protein; Similarity with AF1613, AF0594, PAB089 and PH0696. (114 aa) |
| | SSO2107 | Hypothetical protein. (106 aa) |
| | glpK-2 | Glycerol kinase (glpK-2); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (499 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa) |
| | SSO2291 | Protein kinase, putative; Serine/threonine-type; Cellular Processes. (554 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa) |
| | SSO2374 | Conserved hypothetical protein; MJ0444. (254 aa) |
| | thiD-2 | Phosphomethylpyrimidine kinase (thiD-2); Cofactor Biosynthesis, Thiamine. (456 aa) |
| | SSO2397 | Conserved hypothetical protein. (271 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa) |
| | dpo4 | DNA polymerase IV (family Y) (dpo4); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. (352 aa) |
| | rbsK-2 | Ribokinase (rbsK-2); Energy Metabolism. (283 aa) |
| | SSO2479 | Similarity with glucose 1 and mannose 1 phosphate nucleotidyl transferases; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (237 aa) |
| | SSO2605 | ABC transporter, ABC1 family, putative; Transport. (496 aa) |
| | SSO2635 | Hypothetical protein. (465 aa) |
| | ppsA-2 | Phosphoenolpyruvate synthase (ppsA-2); Energy Metabolism, Glycolysis. (312 aa) |
| | sat | Sulfate adenylyltransferase (sat); Central Intermediary Metabolism, Sulfur. (406 aa) |
| | SSO2988 | (Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa) |
| | SSO3182 | Serine/threonine protein kinase, putative; Regulation. (635 aa) |
| | kdgK | Fructokinase; Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively. (313 aa) |
| | SSO3207 | Ser/thr protein kinase, putative; Regulation. (669 aa) |
| | SSO3218 | Conserved hypothetical protein. (298 aa) |
| | SSO3219 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (253 aa) |
| | cobS | Cobalamin synthase related protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa) |
| | rpoB2 | DNA-directed RNA polymerase, subunit B'' (rpoB2); Transcription, RNA polymerase and transcription factors; Belongs to the RNA polymerase beta chain family. (480 aa) |
| | rpoN | DNA-directed RNA polymerase, subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (66 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (84 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (92 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P (rpoP); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (48 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K (rpoK); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (95 aa) |
