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| | valS | Valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (842 aa) |
| | SSO0870 | Conserved hypothetical protein; Similar to PAB1504. (206 aa) |
| | argS | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (625 aa) |
| | gatA-1 | Glutamyl-tRNA amidotransferase, subunit A (gatA-1); Translation, .tRNAs. (398 aa) |
| | ileS | Isoleucine-tRNA synthetase (ileS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (986 aa) |
| | SSO0678 | Conserved hypothetical protein. (222 aa) |
| | bioR | Biotin--(acetyl-CoA carboxylase) synthetase (bioR); Cofactor Biosynthesis, Biotin. (233 aa) |
| | SSO0658 | Conserved hypothetical protein. (224 aa) |
| | rimK-2 | Translation, Protein modification. (282 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa) |
| | queC | Transcription regulator (exsB) related protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. (464 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | tyrS | Tyrosyl-tRNA synthetase (tyrS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (366 aa) |
| | lysS | Lysyl-tRNA synthetase (lysS); Translation, Aminoacyl tRNA synthetases. (494 aa) |
| | gltX | Glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (575 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha subunit (pheS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (468 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta subunit (pheT); Translation, Aminoacyl tRNA synthetases. (544 aa) |
| | rimK-1 | Ribosomal protein S6 modification protein (rimK-1); Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma- carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily. (286 aa) |
| | aspS | Aspartyl-tRNA synthetase (aspS); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (429 aa) |
| | lig | DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (601 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa) |
| | gatB-1 | Glutamyl-tRNA -Gln amidotransferase, subunit B (gatB-1); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (458 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | purA | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | tiaS | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (443 aa) |
| | hisS | Histidyl-tRNA synthetase (hisS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-II aminoacyl-tRNA synthetase family. (426 aa) |
| | thiF | Thiamine biosynthesis protein related protein (thiF); Cofactor Biosynthesis, Thiamine. (333 aa) |
| | alaS | Alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (900 aa) |
| | SSO0354 | Nicotinic acid phosphoribosyltransferase, putative; Cofactor Biosynthesis, Pyridine nucleotides. (387 aa) |
| | glnA-1 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-1); Amino Acid Biosynthesis, Glutamate. (471 aa) |
| | fadD-1 | Long-chain-fatty-acid--CoA ligase (fadD-1); Lipid metabolism. (454 aa) |
| | cbiA | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (434 aa) |
| | glyS | Glycyl-tRNA synthetase (glyS); Translation, Aminoacyl tRNA synthetases. (574 aa) |
| | alaS-like1 | Alanyl-tRNA synthetase truncated homolog (alaS-like1); Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala). (236 aa) |
| | trpS | Tryptophanyl-tRNA synthetase (trpS); Homology to human, rabbit and yeast versions of protein; Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (386 aa) |
| | SSO0456 | Conserved hypothetical protein; Match is best in just one domain of protein. (241 aa) |
| | leuS-1 | Leucyl-tRNA synthetase (leuS-1); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (934 aa) |
| | SSO0544 | Conserved hypothetical protein. (245 aa) |
| | metS | Methionyl-tRNA synthetase (metS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (573 aa) |
| | atpE | ATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | atpA | ATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa) |
| | atpB | ATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | ATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | proS | Prolyl -tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa) |
| | leuS-2 | Leucyl-tRNA synthetase (leuS-2); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (944 aa) |
| | serS | Seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (457 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | metS-like | Methionyl-tRNA synthetase N-term homolog (metS-like); Translation, Aminoacyl tRNA synthetases. (162 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa) |
| | argG | Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | acsA-3-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa) |
| | gatC | Glutamyl-tRNA-Gln amidotransferase, subunit C (gatC); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | atpG | ATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa) |
| | guaA-2 | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | lplA-2 | Lipoate-protein ligase A (lplA-2); Cofactor Biosynthesis. (264 aa) |
| | lplA-1 | Lipoate-protein ligase A (lplA-1); Cofactor Biosynthesis. (247 aa) |
| | fadD-3 | Long-chain-fatty-acid--CoA ligase (fadD-3); Lipid metabolism. (513 aa) |
| | alkK-4 | Medium-chain-fatty-acid--CoA ligase (alkK-4); Lipid metabolism. (537 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | alkK-3 | Medium-chain-fatty-acid--CoA ligase (alkK-3); Lipid metabolism. (507 aa) |
| | SSO2627 | CoA-ligase / coenzyme F390 synthetase, putative; C-terminal fragment. Frameshift with SSO10784; Cofactor Biosynthesis. (339 aa) |
| | glnA-3 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-3); Amino Acid Biosynthesis, Glutamate; Belongs to the glutamine synthetase family. (429 aa) |
| | fadD-2 | Long-chain-fatty-acid--CoA ligase (fadD-2); Lipid metabolism. (559 aa) |
| | alkK-2 | Medium-chain-fatty-acid--CoA ligase (alkK-2); Lipid metabolism. (552 aa) |
| | thrS | Threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr); unlike most archaea the editing function is found in a freestanding protein (ACQ980D1). In vitro when both subunits are present, or if the 2 subunits are fused, L-seryl-tRNA(Thr) is no longer produced, the 2 subunits edit incorrectly charged L-seryl- tRNA(Thr). Has no activity on correctly acylated L- seryl-tRNA(Ser) [...] (545 aa) |
| | sucC | Succinyl-CoA synthetase, beta subunit (sucC); Energy Metabolism. (337 aa) |
| | sucD | Succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (260 aa) |
| | accC | Biotin carboxylase a subunit of propionyl-CoA carboxylase (accC); Lipid metabolism. (510 aa) |
| | SSO2464 | Biotin carboxyl carrier protein of propionyl-CoA carboxylase beta subunit; Lipid metabolism. (186 aa) |
| | ppcB | Propionyl-CoA carboxylase beta subunit (ppcB); Lipid metabolism. (523 aa) |
| | guaA | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | rtcA | RNA 3' terminal phosphate cyclase (RNA 3' phosphate cyclase) (RNA cyclase) (rtcA); Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). (345 aa) |
| | glnA-2 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-2); Amino Acid Biosynthesis, Glutamate; Belongs to the glutamine synthetase family. (425 aa) |
| | SSO2399 | Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa) |
| | cysS | Cysteinyl-tRNA synthetase (cysS); Translation, Aminoacyl tRNA synthetases. (470 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | nadE | NH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | acsA-6 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa) |
| | acsA-5 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa) |
| | acsA-4-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment (acsA-4); Possible frameshift with SSO2020 and SSO9518; Lipid metabolism. (267 aa) |
| | acsA-4 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment (acsA-4); Possible frameshift with SSO2021; Lipid metabolism. (288 aa) |
| | acsA-3 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Carboxy-end is SSO9201; Lipid metabolism. (457 aa) |
| | SSO1806 | Conserved hypothetical protein. (660 aa) |
| | acd-2 | Acyl-CoA dehydrogenase (acd-2); Lipid metabolism. (516 aa) |
| | alkK-1 | Medium-chain-fatty-acid--CoA ligase (alkK-1); Lipid metabolism. (475 aa) |
| | acsA-2-2 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa) |
| | acsA-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa) |
| | acsA-1 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-1); Lipid metabolism. (529 aa) |
| | SSO1308 | Conserved hypothetical protein. (449 aa) |
| | lplA-like2 | Lipoate protein ligase A, hypothetical (lplA-like2); Cofactor Biosynthesis. (344 aa) |
| | SSO10784 | CoA-ligase / coenzyme F390 synthetase, putative; N-terminal fragment. Frameshift with SSO2627; Cofactor Biosynthesis. (84 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | lplA-like1 | Lipoate protein ligase A, hypothetical (lplA-like1); Cofactor Biosynthesis. (279 aa) |
| | ThpR | Conserved hypothetical protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (194 aa) |
| | rtcB | Conserved hypothetical protein; Belongs to the RtcB family. (482 aa) |
| | gatA-2 | Glutamyl-tRNA amidotransferase, subunit A (gatA-2); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (478 aa) |
| | ansA | Asparinase (ansA); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (444 aa) |
| | gatB-2 | Glutamyl-tRNA -Gln amidotransferase, subunit B (gatB-2); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (633 aa) |
