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| | thiD-1 | Phosphomethylpyrimidine kinase (thiD-1); Cofactor Biosynthesis, Thiamine. (400 aa) |
| | queC | Transcription regulator (exsB) related protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. (464 aa) |
| | moaB | Cofactor Biosynthesis, Molybdopterin. (182 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | SSO0054 | Conserved hypothetical protein. (179 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (265 aa) |
| | SSO0076 | Conserved hypothetical protein; Similarity with AF2363, MJ1416, MTH1525. Weakly related to hydrogenase expression/formation protein HypE. (432 aa) |
| | dnaG | Bacterial-like DNA primase (dnaG); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Can use NTPs but not dNTPs. Binds DNA. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine- rich transcripts and the exosome. Belongs to the archaeal DnaG primase family. (406 aa) |
| | dpo3 | DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair. (764 aa) |
| | cinA | Competence damage protein (cinA); Regulation; Belongs to the CinA family. (272 aa) |
| | cbiG | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. (293 aa) |
| | SSO0140 | Primase (Carboxy-end fragment); Encoded by Sulfolobus plasmids; Replication and Repair. (532 aa) |
| | SSO0172 | Conserved hypothetical protein. (170 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa) |
| | HemB | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. (341 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase (hemL); Cofactor Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (426 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (293 aa) |
| | SSO0184 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (237 aa) |
| | lig | DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (601 aa) |
| | dcD-1 | Deoxycytidine triphosphate deaminase (dcD-1); Catalyzes the deamination of dCTP to dUTP. (206 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa) |
| | hpS-2 | D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hpS-2); Similar to amino-end of most thermophilic homologues but same size as bacterial homologues. Carboxy-end seems to be upstream in distal SSO0151 orf; Energy Metabolism, Sugar metabolism. (225 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa) |
| | nusA | Transcription termination factor nusA homolog, putative (nusA); Participates in transcription termination. Belongs to the NusA family. (124 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A'' (rpoA2); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (395 aa) |
| | rpoA1 | DNA-directed RNA polymerase, subunit A' (rpoA1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (880 aa) |
| | rpoB1 | DNA-directed RNA polymerase, subunit B' (rpoB1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (649 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | upP | Uracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | SSO0233 | Conserved hypothetical protein; Seems related to pur operon repressor. Similar to PH1691, PAB2035, APE0060. (246 aa) |
| | thiL | Thiamine monophosphate kinase, putative (thiL); Cofactor Biosynthesis, Thiamine. (323 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | purB | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | purA | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | cyaB | Adenylate cyclase, cyaB-type, putative (cyaB); Cellular Processes, Purines. (186 aa) |
| | SSO0255 | Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides. (117 aa) |
| | SSO0260 | Conserved hypothetical protein. (107 aa) |
| | tfE | Transcription Factor E (TFE), TFIIE alpha subunit homolog (tfE); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and d [...] (178 aa) |
| | tgtA | Queuine/archaeosine-tRNA -ribosyltransferase (tgtA); Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (503 aa) |
| | SSO0280 | Hypothetical protein; Similar to S. shibatae YTF2_SULSH (P46221) protein in TF55 5' region. (170 aa) |
| | rpoM-1 | DNA-directed RNA polymerase, subunit M (rpoM-1); Possible in-frame shift with SSO5576. Similar to carboxy-end of RPOM_SULAC, but most other thermophilic genes are the same size; Transcription, RNA polymerase and transcription factors; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (114 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | thyX | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (260 aa) |
| | thiI | Thiamine biosynthesis protein thiI (thiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (371 aa) |
| | SSO0354 | Nicotinic acid phosphoribosyltransferase, putative; Cofactor Biosynthesis, Pyridine nucleotides. (387 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (308 aa) |
| | folE | GTP cyclohydrolase I (folE); Purines. (208 aa) |
| | nirJ-like | Heme biosynthesis related protein (nirJ-like); Only one domain shows homology; Cofactor Biosynthesis, Heme. (322 aa) |
| | SSO0377 | Conserved hypothetical protein. (172 aa) |
| | SSO0381 | Sugar phosphate nucleotydyl transferase; Several close hits to other proteins; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (363 aa) |
| | ribH | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribC | Riboflavin synthase (ribC); Cofactor Biosynthesis, Riboflavin. (155 aa) |
| | ribA | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. (219 aa) |
| | cbiA | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (434 aa) |
| | cbiX | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. (128 aa) |
| | rpoE1 | DNA-directed RNA polymerase, subunit E' (rpoE1); Transcription, RNA polymerase and transcription factors. (180 aa) |
| | SSO0416 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa) |
| | SSO0429 | Hypothetical protein. (326 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (267 aa) |
| | TFB-1 | Transcription initiation factor IIB (TFIIB) homolog (TFB-1); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (309 aa) |
| | SSO0456 | Conserved hypothetical protein; Match is best in just one domain of protein. (241 aa) |
| | SSO0461 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa) |
| | proC | Pyrroline-5-carboxylate reductase (P5CR) (P5C reductase) (proC); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa) |
| | dpo1 | DNA polymerase I (DNA polymerase B1) (dpo1); This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (882 aa) |
| | priL | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. (307 aa) |
| | atpF | ATP synthase subunit F (atpF); Energy Metabolism, ATP-Proton Motive Force. (100 aa) |
| | atpE | ATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | atpA | ATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa) |
| | atpB | ATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | ATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | pdxS | Ethylene-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (338 aa) |
| | pdxT | Glutamine amidotransferase, putative; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa) |
| | ilvB-2 | Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa) |
| | SSO0588 | Conserved hypothetical protein; Similar to SSO0377. (174 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. (232 aa) |
| | serS | Seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (457 aa) |
| | SSO0605 | Zn finger protein, hypothetical; Similar to rpoM; Uncategorized. (116 aa) |
| | pyrD | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa) |
| | pyrC | Dihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa) |
| | SSO0612 | Hypothetical protein. (208 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa) |
| | queE | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (211 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purF-1 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa) |
| | purF-2 | Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa) |
| | ctaB | Cytochrome C oxidase folding protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (286 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B (mobB); Cofactor Biosynthesis, Molybdopterin. (169 aa) |
| | moeA-1 | Cofactor Biosynthesis, Molybdopterin. (389 aa) |
| | mobA | Molybdopterin guanine dinucleotide biosynthesis; Cofactor Biosynthesis, Molybdopterin. (194 aa) |
| | cmK | Cytidylate kinase (cmK); Pyrimidines. (189 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | SSO0745 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (407 aa) |
| | rpoF | DNA-directed RNA polymerase, subunit F (rpoF); Transcription. (113 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C (moaC); Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (149 aa) |
| | tmK-1 | Thymidylate kinase (tmK-1); Pyrimidines. (189 aa) |
| | SSO0781 | Conserved hypothetical protein; Belongs to the UPF0148 family. (118 aa) |
| | ugd | UDP-glucose 6-dehydrogenase (ugd); Central Intermediary Metabolism. (409 aa) |
| | rfbC-1 | dTDP-4-dehydrorhamnose 3,5 epimerase (rfbC-1); Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (176 aa) |
| | SSO0869 | Conserved hypothetical protein; Similarity with SSO1527. (356 aa) |
| | trpB | Tryptophan synthase beta chain (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (425 aa) |
| | trpA | Tryptophan synthase alpha chain (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (245 aa) |
| | trpD | Anthranilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpF | Phosphoribosyl anthranilate isomerase (trpF); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the TrpF family. (204 aa) |
| | trpE | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (421 aa) |
| | trpGD | Anthranilate synthase component II (trpGD); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (195 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (trpC); Amino Acid Biosynthesis, Aromatic amino acids. (248 aa) |
| | nrd | Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (841 aa) |
| | TFB-2 | Transcription initiation factor IIB (TFIIB) homolog (TFB-2); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (293 aa) |
| | tfIID | TATA box binding protein, hypothetical (tfIID); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). (181 aa) |
| | ribK | Hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa) |
| | pyrH | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa) |
| | NadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (275 aa) |
| | nadB | Aspartate oxidase (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate. (487 aa) |
| | nadA | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (311 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | priS | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] (330 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | porD-2 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa) |
| | trpB-like | Tryptophan synthase beta chain, hypothetical (trpB-like); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (429 aa) |
| | acd-1 | Acyl-CoA dehydrogenase (acd-1); Lipid metabolism. (363 aa) |
| | acd-like1 | Acyl-CoA dehydrogenase related protein (acd-like1); Lipid metabolism. (266 aa) |
| | tmk | Thymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa) |
| | tmK-2 | Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa) |
| | porG-1 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa) |
| | SSO1224 | Conserved hypothetical protein; Putative extracellular protein; hit to glycerol dehydratase. (139 aa) |
| | paaX | Repressor in ring oxydation complex/ phenylacetic acid degradation pathway related protein (paaX); Cellular Processes, Detoxification. (266 aa) |
| | thiC-1 | Thiamine biosynthesis protein (thiC-1); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | acsA-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa) |
| | acsA-2-2 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa) |
| | pdhA-1 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-1); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (345 aa) |
| | pdhB-1 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-1); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | dpo2 | DNA polymerase II (DNA polymerase B2) carboxy-end (dpo2); This polymerase is devoid of exonuclease activity; Belongs to the DNA polymerase type-B family. (561 aa) |
| | pdhA-2 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-2); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | pdhB-2 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-2); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (324 aa) |
| | acoX | Acetoin catabolism protein X homolog (acoX); Unknown function in acoXABC operon; Energy Metabolism. (339 aa) |
| | pqqE-2 | Coenzyme PQQ synthesis protein E (pqqE-2); Multicopy. Similar to SSO1840; Cofactor Biosynthesis, Quinones. (350 aa) |
| | pqqE-3 | Coenzyme PQQ synthesis protein E (pqqE-3); Multicopy. Similar to SSO1839; Cofactor Biosynthesis, Quinones. (378 aa) |
| | pqqE-4 | Coenzyme PQQ synthesis protein E (pqqE-4); Multicopy. Similar to SSO1632; Cofactor Biosynthesis, Quinones. (378 aa) |
| | pqqE-5 | Coenzyme PQQ synthesis protein E (pqqE-5); Cofactor Biosynthesis, Quinones. (350 aa) |
| | rfbC-2 | dTDP-4-dehydrorhamnose 3,5 epimerase (rfbC-2); Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (176 aa) |
| | thiC-2 | Thiamine biosynthesis protein (thiC-2); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | SSO2022 | Ring oxydation complex/ phenylacetic acid degradation related protein; Cellular Processes, Detoxification. (266 aa) |
| | acsA-6 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa) |
| | acd-3 | Acyl-CoA dehydrogenase (acd-3); Lipid metabolism. (371 aa) |
| | iorB | Indolepyruvate ferredoxin oxidoreductase beta subunit (iorB); Energy Metabolism. (194 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | ribD | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. (213 aa) |
| | porD-like | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa) |
| | SSO2151 | Conserved hypothetical protein; Similarity with aq_477. (113 aa) |
| | SSO2169 | Conserved hypothetical protein; Similarity with APE0237. (223 aa) |
| | SSO2171 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (175 aa) |
| | nadE | NH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa) |
| | SSO2187 | Pterin-4-alpha-carbinolamine dehydratase, putative; Cofactor Biosynthesis. (114 aa) |
| | SSO2211 | Conserved hypothetical protein; Similar to AF0577. (350 aa) |
| | SSO2213 | Conserved hypothetical protein; Similar to PH0034, PAB2326, AF0276, MTH1426, APE2029, MJ1598, Ta0078; Belongs to the UPF0284 family. (347 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa) |
| | cbiE | Cobalamin biosynthesis precorrin-6B methylase, putative (cbiE); Cofactor Biosynthesis. (227 aa) |
| | cbiG-like | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. (337 aa) |
| | cbiF | Cobalamin biosynthesis precorrin-3 methylase, putative (cbiF); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. (262 aa) |
| | cbiL | Cobalamin biosynthesis precorrin-2 methyltransferase, putative (cbiL); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. (222 aa) |
| | cbiT | Cobalamin biosynthesis precorrin-8W decarboxylase, putative (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (199 aa) |
| | cbiD | Cobalamin biosynthesis protein D, putative (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (349 aa) |
| | cbiH | Cobalamin biosynthesis precorrin-3 methylase, putative (cbiH); Cofactor Biosynthesis. (250 aa) |
| | cbiC | Cobalamin biosynthesis precorrin isomerase, putative (cbiC); Cofactor Biosynthesis. (332 aa) |
| | SSO2309 | PpqE-type; Cofactor Biosynthesis. (344 aa) |
| | gpT-1 | Purine phosphoribosyltransferase (gpT-1); Purines. (210 aa) |
| | mtaP | 5'-methylthioadenosine phosphorylase (mtaP); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (270 aa) |
| | moeA-2 | Cofactor Biosynthesis, Molybdopterin. (550 aa) |
| | thiD-2 | Phosphomethylpyrimidine kinase (thiD-2); Cofactor Biosynthesis, Thiamine. (456 aa) |
| | moaE | Cofactor Biosynthesis, Molybdopterin. (231 aa) |
| | SSO2397 | Conserved hypothetical protein. (271 aa) |
| | SSO2399 | Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa) |
| | panB | Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa) |
| | SSO2412 | Conserved hypothetical protein; Putative 6-pyruvoyl tetrahydrobiopterin synthase. (138 aa) |
| | gpT-2 | Purine phosphoribosyltransferase (gpT-2); Similar to APE2071 and PAB0060; Purines. (179 aa) |
| | cobA | Uroporphyrinogen III methylase (cobA); Cofactor Biosynthesis. (242 aa) |
| | dpo4 | DNA polymerase IV (family Y) (dpo4); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. (352 aa) |
| | guaA | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | acd-like2 | Acyl-CoA dehydrogenase related protein (acd-like2); Lipid metabolism. (299 aa) |
| | nrdB | Ribonucleotide reductase small subunit, probable (nrdB); Purines. (308 aa) |
| | acd-4 | Acyl-CoA dehydrogenase (acd-4); Lipid metabolism. (370 aa) |
| | SSO2634 | Conserved hypothetical protein. (140 aa) |
| | SSO2705 | Regucalcin homolog; Strong similarity with eukaryotic regucalcin genes. SMP-30 / CGR1 family protein; Uncategorized. (285 aa) |
| | porG-2 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa) |
| | acd-5 | Acyl-CoA dehydrogenase (acd-5); Lipid metabolism. (398 aa) |
| | SSO2815 | 2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa) |
| | SSO2816 | 2-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa) |
| | fdhD | FDHD protein homolog (fdhD); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (257 aa) |
| | SSO2832 | Conserved hypothetical protein. (233 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | SSO2865 | Hypothetical protein. (104 aa) |
| | acd-6 | Acyl-CoA dehydrogenase (acd-6); Lipid metabolism. (400 aa) |
| | cysG | Uroporphyrin-III C-methyltransferase (siroheme synthase) (cysG); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. (231 aa) |
| | dcD-2 | Deoxycytidine triphosphate deaminase (dcD-2); Pyrimidines. (166 aa) |
| | SSO3041 | Conserved hypothetical protein. (285 aa) |
| | lipA | Lipoic acid synthetase (lipoate synthase) (lipA); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. (285 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | guaA-2 | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (465 aa) |
| | cobS | Cobalamin synthase related protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa) |
| | cbiB | Cobalamin biosynthesis protein B (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (305 aa) |
| | rpoB2 | DNA-directed RNA polymerase, subunit B'' (rpoB2); Transcription, RNA polymerase and transcription factors; Belongs to the RNA polymerase beta chain family. (480 aa) |
| | rpoN | DNA-directed RNA polymerase, subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (66 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (84 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (92 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P (rpoP); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (48 aa) |
| | atpG | ATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K (rpoK); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (95 aa) |
| | porD-1 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa) |
| | acsA-3-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa) |
| | rpoM-2 | DNA-directed RNA polymerase, subunit M (rpoM-2); Transcription, RNA polymerase and transcription factors. (92 aa) |
