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| | SSO0051 | Conserved hypothetical protein. (336 aa) |
| | soj | SOJ protein (soj); Regulation. (220 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | moaB | Cofactor Biosynthesis, Molybdopterin. (182 aa) |
| | SSO0017 | Lhr-like protein; Helicases. (739 aa) |
| | queC | Transcription regulator (exsB) related protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. (464 aa) |
| | rbsK-1 | Ribokinase (rbsK-1); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa) |
| | SSO0473 | Close hits to probable DNA repair proteins and helicases; Replication and Repair, Helicases. (444 aa) |
| | SSO0470 | Conserved hypothetical protein; Might have a GTP binding domain. (301 aa) |
| | SSO0461 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa) |
| | SSO1939 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2139,SSO2730,SSO2101,SSO1545,SSO1196,SSO1330/SSO3257. (387 aa) |
| | SSO1963 | Hypothetical protein; Some similarity with PH0691, PAB1420 and MJ1544. (141 aa) |
| | SSO1994 | Conserved hypothetical protein; Putative ATPase. (328 aa) |
| | SSO1999 | ATP-dependent RNA helicase homolog; Helicases, Helicases. (515 aa) |
| | acsA-4 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment (acsA-4); Possible frameshift with SSO2021; Lipid metabolism. (288 aa) |
| | acsA-4-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment (acsA-4); Possible frameshift with SSO2020 and SSO9518; Lipid metabolism. (267 aa) |
| | SSO2030 | ABC transporter; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (530 aa) |
| | SSO2036 | ATP-dependent RNA helicase; DEAD-family; Helicases; Belongs to the DEAD box helicase family. (360 aa) |
| | acsA-5 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa) |
| | SSO2101 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2139,SSO2730,SSO1545,SSO1939,SSO1196,SSO1330/SSO3257. (360 aa) |
| | SSO2116 | Cobalt transport ATP-binding protein (cbiO-2) homolog, putative; ABC transporter, ATP-binding protein; Transport. (257 aa) |
| | glpK-2 | Glycerol kinase (glpK-2); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (499 aa) |
| | SSO2137 | ABC transporter, ATP binding protein; Transport. (339 aa) |
| | SSO2139 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2730,SSO2101,SSO1545,SSO1939,SSO1196,SSO1330/SSO3257. (395 aa) |
| | SSO2171 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (175 aa) |
| | nadE | NH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa) |
| | cdc6-3 | Cell division control 6/orc1 protein homolog (cdc6-3); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Inhibits the DNA- binding activity of Cdc6-1 and Cdc6-2. (394 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa) |
| | bps2 | BPS2 protein homolog (bps2); Very strong similarity withe BSP2 protein from Desulfurolobus ambivalens; Uncategorized. (587 aa) |
| | rad50 | Purine NTPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (864 aa) |
| | herA | Conserved hypothetical protein; Involved in DNA double-strand break (DSB) repair. Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity. Belongs to the HerA family. (500 aa) |
| | nnrD | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] (501 aa) |
| | MeaB | Conserved hypothetical protein; Putative transport system kinase, argK family protein. (315 aa) |
| | SSO2277 | Conserved hypothetical protein. (495 aa) |
| | cysS | Cysteinyl-tRNA synthetase (cysS); Translation, Aminoacyl tRNA synthetases. (470 aa) |
| | SSO2285 | Hypothetical protein; Some similarity with APE0080. (609 aa) |
| | SSO2291 | Protein kinase, putative; Serine/threonine-type; Cellular Processes. (554 aa) |
| | FlaH | Flagella-related protein H, putative (FlaH); (MJ0899); Cellular Processes, Motility. (234 aa) |
| | SSO2331 | Hypothetical protein. (256 aa) |
| | SSO2332 | Conserved hypothetical protein; Similarity with plasmid partitioning protein (ParA). (255 aa) |
| | SSO2336 | Hypothetical protein. (206 aa) |
| | rimK-3 | Translation, Protein modification. (230 aa) |
| | SSO2363 | Conserved hypothetical protein; Similar to APE1035. (382 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa) |
| | SSO2374 | Conserved hypothetical protein; MJ0444. (254 aa) |
| | SSO2385 | GTP binding conserved hypothetical protein; Belongs to GTP1/OBG family; Uncategorized. (351 aa) |
| | SSO2397 | Conserved hypothetical protein. (271 aa) |
| | SSO2399 | Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa) |
| | SSO2402 | ABC transporter, ATP binding protein; Transport. (248 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa) |
| | SSO2420 | AAA family ATPase; Cellular processes. (607 aa) |
| | tuF-2 | Elongation factor 1-alpha, putative (tuF-2); SSO0216 homolog; Translation, Translation factors. (523 aa) |
| | rtcA | RNA 3' terminal phosphate cyclase (RNA 3' phosphate cyclase) (RNA cyclase) (rtcA); Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). (345 aa) |
| | SSO2450 | TATA binding protein (TBP)-interacting protein (TIP49-like), putative; E. coli ruvB and eucaryotic TIP49 homolog; Transcription. (476 aa) |
| | guaA | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | SSO2452 | Conserved hypothetical protein; Similar to APE0745 amino end, PH0284, APE1505, TM0370, PAB2180, MJ1359. (262 aa) |
| | hel308 | DNA helicase related protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (715 aa) |
| | accC | Biotin carboxylase a subunit of propionyl-CoA carboxylase (accC); Lipid metabolism. (510 aa) |
| | SSO2468 | ABC transporter, putative; Transport. (535 aa) |
| | SSO2469 | ABC transporter, ATP binding protein, putative; Contains WD repeats (TRP ASP domains) signature; Transport. (238 aa) |
| | SSO2475 | Hypothetical protein; Similarity with plasmid partition proteins from B. burgdorferi Orf1, BBN32, BBL32 and orfC. (244 aa) |
| | sucC | Succinyl-CoA synthetase, beta subunit (sucC); Energy Metabolism. (337 aa) |
| | thrS | Threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr); unlike most archaea the editing function is found in a freestanding protein (ACQ980D1). In vitro when both subunits are present, or if the 2 subunits are fused, L-seryl-tRNA(Thr) is no longer produced, the 2 subunits edit incorrectly charged L-seryl- tRNA(Thr). Has no activity on correctly acylated L- seryl-tRNA(Ser) [...] (545 aa) |
| | SSO2492 | Hypothetical protein; Weak similarity with several B. burgdorferi conserved proteins. (201 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (603 aa) |
| | SSO2600 | ABC transporter, ATP binding protein; Transport. (249 aa) |
| | SSO2605 | ABC transporter, ABC1 family, putative; Transport. (496 aa) |
| | dppF-3 | Dipeptide ABC transporter ATP binding protein (dppF-3); Transport, Cell membrane transport. (323 aa) |
| | dppD-3 | Dipeptide ABC transporter ATP binding protein (dppD-3); Transport, Cell membrane transport. (324 aa) |
| | SSO2635 | Hypothetical protein. (465 aa) |
| | SSO2646 | Conserved hypothetical protein; Putative ABC transporter. Similarity with TM1326,TM1304, APE2514, PH1848. (271 aa) |
| | SSO2647 | ABC transporter, ATP binding protein; Transport. (309 aa) |
| | pacS | Cation transporting ATPase (pacS); Transport. (755 aa) |
| | SSO2670 | ABC transporter, ATP binding protein; Transport. (362 aa) |
| | SSO2672 | ABC transporter, ATP binding protein; Transport. (324 aa) |
| | SSO2708 | Hydrogenase expression/formation factor related protein; Protein modification. (341 aa) |
| | SSO2713 | ABC transporter, ATP binding protein; Transport. (314 aa) |
| | SSO2730 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2139,SSO2101,SSO1545,SSO1939,SSO1196,SSO1330/SSO3257. (377 aa) |
| | SSO2831 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes; Belongs to the AAA ATPase family. (585 aa) |
| | SSO2836 | ABC transporter, ATP binding protein (branched chain amino acid); Transport. (248 aa) |
| | SSO2838 | ABC transporter, ATP binding protein (branched chain amino acid); Transport. (236 aa) |
| | glcV | ABC transporter, ATP binding protein (glucose); Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system. In vitro, as a free subunit, exhibits a constitutive ATPase activity. (353 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | CadA | Copper-transporting ATPase; Transport. (695 aa) |
| | sat | Sulfate adenylyltransferase (sat); Central Intermediary Metabolism, Sulfur. (406 aa) |
| | SSO2988 | (Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa) |
| | MvaD | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. (325 aa) |
| | thsC | Thermosome subunit gamma; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. (539 aa) |
| | SSO3012 | ABC transporter, ATP binding protein; Transport. (863 aa) |
| | SSO3045 | ABC transporter, ATP binding protein; Substrate: oligo-/di-peptide, sugar; Transport. (267 aa) |
| | SSO3046 | ABC transporter, ATP binding protein; Substrate: oligo-/di-peptide, sugar; Transport. (331 aa) |
| | SSO3055 | Maltose ABC transporter, ATP-binding protein; Albers, S.-V., Elferink,M.G.L., Konings, W.N., Driessen, A.J.M., pers. comm; Transport. (617 aa) |
| | SSO3069 | Arabinose ABC transporter, ATP-binding protein; Albers, S.-V., Elferink,M.G.L., Konings, W.N., Driessen, A.J.M., pers. comm; Transport. (371 aa) |
| | SSO3083 | ABC transporter, ATP binding protein, putative; Transport. (291 aa) |
| | SSO3093 | ABC transporter, ATP binding protein, putative; Transport. (237 aa) |
| | SSO3169 | ABC transporter, ATP binding protein related protein; Transport. (275 aa) |
| | SSO3182 | Serine/threonine protein kinase, putative; Regulation. (635 aa) |
| | kdgK | Fructokinase; Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively. (313 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | SSO3207 | Ser/thr protein kinase, putative; Regulation. (669 aa) |
| | tmcA-2 | Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (770 aa) |
| | SSO3218 | Conserved hypothetical protein. (298 aa) |
| | guaA-2 | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa) |
| | SSO3248 | Conserved hypothetical protein; Similar to Ta1176. (156 aa) |
| | SSO3257 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted).Possible frameshift with SSO1330. (182 aa) |
| | atpG | ATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa) |
| | hisE | Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis. (97 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | gatC | Glutamyl-tRNA-Gln amidotransferase, subunit C (gatC); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa) |
| | SSO8687 | Partial transposase ISC1190. (88 aa) |
| | acsA-3-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa) |
| | atpK | ATP synthase subunit K (atpK); Energy Metabolism, ATP-Proton Motive Force; Belongs to the V-ATPase proteolipid subunit family. (102 aa) |
| | atpD | ATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | atpB | ATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpA | ATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa) |
| | atpE | ATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | metS | Methionyl-tRNA synthetase (metS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (573 aa) |
| | SSO0544 | Conserved hypothetical protein. (245 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | SSO0485 | ABC transporter; Putative periplasmic-binding protein; Transport. (318 aa) |
| | SSO0487 | Iron (III) ABC transporter, ATP-binding protein; Transport. (219 aa) |
| | pstB | Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa) |
| | leuS-1 | Leucyl-tRNA synthetase (leuS-1); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (934 aa) |
| | mrp | MRP protein homolog, conserved ATPase (mrp); Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP. (296 aa) |
| | trpS | Tryptophanyl-tRNA synthetase (trpS); Homology to human, rabbit and yeast versions of protein; Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (386 aa) |
| | alaS-like1 | Alanyl-tRNA synthetase truncated homolog (alaS-like1); Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala). (236 aa) |
| | glyS | Glycyl-tRNA synthetase (glyS); Translation, Aminoacyl tRNA synthetases. (574 aa) |
| | SSO0433 | O-sialoglycoprotein endopeptidase; Protein modification. (223 aa) |
| | SSO0421 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. (769 aa) |
| | topR-1 | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] (1242 aa) |
| | eif2G | Translation initiation factor eiF 2 gamma (eif2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. (415 aa) |
| | cbiA | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (434 aa) |
| | SSO1038 | Conserved hypothetical protein; Similarity with APE1790, PH1307. (256 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (412 aa) |
| | adkA-like | Adenylate kinase related protein (adkA-like); Purines; Belongs to the UPF0200 family. (188 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | SSO1078 | ABC transporter, ATP binding subunit; Transport. (225 aa) |
| | SSO1144 | ABC transporter, ATP binding protein; Transport. (275 aa) |
| | SSO1155 | Conserved hypothetical protein. (432 aa) |
| | SSO1168 | Sugar ABC transporter; Transport, Cell membrane transport. (368 aa) |
| | tmK-2 | Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa) |
| | SSO1196 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2139,SSO2730,SSO2101,SSO1545,SSO1939,SSO1330/SSO3257. (196 aa) |
| | SSO1204 | Hypothetical protein; Adhesion molecule in mycoplasma. (114 aa) |
| | SSO1224 | Conserved hypothetical protein; Putative extracellular protein; hit to glycerol dehydratase. (139 aa) |
| | SSO1266 | ABC transporter, ATP binding protein; Transport. (286 aa) |
| | SSO1270 | Hypothetical protein. (464 aa) |
| | dppD-1 | Oligo/dipeptide transport, ATP binding protein (dppD-1); Transport, Cell membrane transport. (316 aa) |
| | dppF-1 | Oligo/dipeptide transport, ATP binding protein (dppF-1); Transport, Cell membrane transport. (325 aa) |
| | dppF-2 | Oligo/dipeptide transport, ATP binding protein. carboxy-end fragment. (dppF-2); Interrupted by transposase in orf SSO1280; Transport, Cell membrane transport. (103 aa) |
| | dppF-2-2 | Oligo/dipeptide transport, ATP binding protein. amino-end fragment. (dppF-2); Interrupted by transposase in orf SSO1280; Transport, Cell membrane transport. (245 aa) |
| | dppD-2 | Oligo/dipeptide transport, ATP binding protein. (dppD-2); Transport, Cell membrane transport. (323 aa) |
| | SSO1289 | Conserved hypothetical protein; Similarity with PH0691, MJ1544, PAB1420. (452 aa) |
| | SSO1294 | Hypothetical protein. (247 aa) |
| | SSO1308 | Conserved hypothetical protein. (449 aa) |
| | acsA-1 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-1); Lipid metabolism. (529 aa) |
| | SSO1319 | Antibiotic ABC transporter, ATP binding protein; Several hits to specific antibiotic ABC transporters; Transport. (297 aa) |
| | SSO1327 | Conserved hypothetical protein; Similar to APE0080. (596 aa) |
| | SSO1328 | Restriction endonuclease related protein; Possibly a 5-methylcytosine-specific restriction enzyme. Some similarity with mcrB (E. coli); Replication and Repair. (559 aa) |
| | SSO1330 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted).Possible frameshift with SSO3257. Similar to SSO2139,SSO2730,SSO2101,SSO1545,SSO1939,SSO1196. (162 aa) |
| | acsA-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa) |
| | acsA-2-2 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa) |
| | Cas3 | ATP-dependent RNA helicase related protein; Helicases. (572 aa) |
| | SSO1418 | Conserved hypothetical protein; Similarity with PAB1355, PH0922, PAB0600, PAB1562, PH0837, PAB0083, TM0616. (409 aa) |
| | SSO1440 | ATP-dependent RNA helicase homolog; Helicases, Helicases. (515 aa) |
| | SSO1456 | Hypothetical protein; Similarity with carboxy-end of some DNA helicases. (139 aa) |
| | SSO1468 | Conserved hypothetical protein; Similarity with MJ1544, PH0691, PAB1420 and HI1038 from H. influenzae. (410 aa) |
| | SSO1545 | Conserved hypothetical protein; Possibly an ATPase of the AAA superfamily (COG1672, predicted). Similar to SSO2139,SSO2730,SSO2101,SSO1939,SSO1196,SSO1330/SSO3257. (356 aa) |
| | SSO1562 | Conserved hypothetical protein; N-terminal domain PAB1355 (frameshift?). (287 aa) |
| | SSO1563 | Conserved hypothetical protein; C-terminal domain PAB1355 (frameshift?). (143 aa) |
| | glpK1 | Transporter/facilitator; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (501 aa) |
| | SSO1645 | Best hit: hypothetical protein (APE2242)[Aeropyrum pernix]. (138 aa) |
| | SSO1653 | Helicase of the snf2/rad54 family (amino end fragment), hypothetical; MG018/MG017/MG016 HOMOLOG. Protein is interrupted by orf SSO1654 encoded transposase; Helicases, Helicases. (802 aa) |
| | SSO1655 | Helicase of the snf2/rad54 family (carboxy end fragment), hypothetical; MG018/MG017/MG016 HOMOLOG. Protein is interrupted by orf SSO1654 encoded transposase; Helicases, Helicases. (124 aa) |
| | SSO1680 | Conserved hypothetical protein; Predicted / Conserved with amino end of Thermotoga and Pyrococcus proteins. (99 aa) |
| | SSO1710 | Hypothetical protein; Weak similarity with ABC Transporter. (464 aa) |
| | SSO1739 | Conserved hypothetical protein. (315 aa) |
| | SSO1789 | Hypothetical protein; Multicopy. Similar to SSO1710. (464 aa) |
| | SSO1861 | Conserved hypothetical protein; Belongs to the UPF0273 family. (280 aa) |
| | SSO1879 | ATP-dependent helicase, putative; Contains a DNA/RNA helicase domain (DEAD/DEAH box); Helicases. (665 aa) |
| | SSO1889 | ATP-dependent RNA helicase; DEAD-family; Helicases; Belongs to the DEAD box helicase family. (343 aa) |
| | SSO1893 | ABC transporter, ATP binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (530 aa) |
| | acsA-3 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Carboxy-end is SSO9201; Lipid metabolism. (457 aa) |
| | SSO1918 | Conserved hypothetical protein; Similarity with MJECL04, PAB0571, PH0977, MTH196, PAB1516, PH0976, PAB1598, PAB1516, PH1263, PH0436, PAB1582, PAB2383, PH0846, PH0830, PAB1371, PAB1412, PH0841. (420 aa) |
| | SSO1934 | Several hits to specific antibiotic ABC transporters; Transport. (297 aa) |
| | proS | Prolyl -tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa) |
| | RsgA | GTP binding protein, hypothetical; Regulation; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (267 aa) |
| | SSO0588 | Conserved hypothetical protein; Similar to SSO0377. (174 aa) |
| | leuS-2 | Leucyl-tRNA synthetase (leuS-2); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (944 aa) |
| | hisG | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | serS | Seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (457 aa) |
| | SSO0625 | GTP-binding protein; Uncategorized. (332 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | metS-like | Methionyl-tRNA synthetase N-term homolog (metS-like); Translation, Aminoacyl tRNA synthetases. (162 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | argG | Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa) |
| | rimK-2 | Translation, Protein modification. (282 aa) |
| | SSO0664 | SUA5 related conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (358 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B (mobB); Cofactor Biosynthesis, Molybdopterin. (169 aa) |
| | mobA | Molybdopterin guanine dinucleotide biosynthesis; Cofactor Biosynthesis, Molybdopterin. (194 aa) |
| | SSO0688 | ABC transporter, ATP binding protein; Transport. (246 aa) |
| | cmK | Cytidylate kinase (cmK); Pyrimidines. (189 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | ileS | Isoleucine-tRNA synthetase (ileS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (986 aa) |
| | EF-2 | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (736 aa) |
| | eiF4A | RNA helicase (ATP dependent)/eIF4A (eiF4A); A structure-specific endonuclease, cleaves 5' of ds/ssDNA interfaces in 3' flap structures, although it also cuts bubble, Y-DNA structures and mobile and immobile Holliday junctions. Cuts preferentially after pyrimidines, may continue to progressively cleave substrate upstream of the initial cleavage, at least in vitro. May be involved in nucleotide excision repair. (233 aa) |
| | YchF | GTP binding protein; Uncategorized. (408 aa) |
| | rfc | Activator 1, replication factor C, small subunit (rfc); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity; Belongs to the activator 1 small subunits family. RfcS subfamily. (330 aa) |
| | rfcL | Activator 1, replication factor C (RFC) large subunit (rfcL); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity; Belongs to the activator 1 small subunits family. RfcL subfamily. (405 aa) |
| | cdc6-2 | Cell division control 6/orc1 protein homolog (cdc6-2); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Has a weak ATPase activity. Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM. Also regulates the DNA polymerase and the nuclease activities of PolB1. (413 aa) |
| | MCM | Minichromosome maintenance protein MCM; Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential [...] (686 aa) |
| | radA-like | DNA repair protein radA homolog (radA-like); Bacterial RadA-like (related to bacterial sequences); Replication and Repair. (175 aa) |
| | tmK-1 | Thymidylate kinase (tmK-1); Pyrimidines. (189 aa) |
| | argS | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (625 aa) |
| | thsA | Thermosome subunit alpha; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. (559 aa) |
| | SSO0870 | Conserved hypothetical protein; Similar to PAB1504. (206 aa) |
| | ppsA-1 | Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | valS | Valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (842 aa) |
| | SSO0909 | AAA family ATPase, p60 katanin; Belongs to the AAA family; Cellular Processes. (372 aa) |
| | SufC | ABC transporter; Transport. (162 aa) |
| | nrd | Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (841 aa) |
| | gatB-2 | Glutamyl-tRNA -Gln amidotransferase, subunit B (gatB-2); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (633 aa) |
| | ansA | Asparinase (ansA); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (444 aa) |
| | SSO0950 | Hypothetical protein. (286 aa) |
| | gatA-2 | Glutamyl-tRNA amidotransferase, subunit A (gatA-2); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (478 aa) |
| | SSO0959 | DNA repair protein rad25; Replication and Repair, Helicases. (551 aa) |
| | topR-2 | Reverse gyrase (topR-2); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1166 aa) |
| | SSO0965 | Lhr-like protein; Helicases. (933 aa) |
| | rtcB | Conserved hypothetical protein; Belongs to the RtcB family. (482 aa) |
| | top6B | DNA topoisomerase VI subunit B (top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (530 aa) |
| | top6A | DNA topoisomerase VI subunit A (top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (389 aa) |
| | srp54 | Signal recognition particle protein subunit SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (447 aa) |
| | pyrH | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | SSO1003 | Sugar ABC transporter; Transport, Cell membrane transport. (324 aa) |
| | SSO1034 | ABC transporter, ATP binding protein; Transport. (204 aa) |
| | gch3 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (231 aa) |
| | SSO0394 | Lhr-like protein; Helicases. (913 aa) |
| | tmcA | Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (743 aa) |
| | thrS-like | Threonyl-tRNA synthetase homolog (thrS-like); Freestanding tRNA editing subunit of threonine--tRNA ligase, the catalytic subunit is AC Q97VW8. Deacylates (edits) mischarged L- seryl-tRNA(Thr) in trans, removing L-serine, has no aminoacylation activity. In vitro when both subunits are present, or if the 2 subunits are fused, L-seryl-tRNA(Thr) is no longer produced. Has no activity on correctly acylated L-seryl-tRNA(Ser) or L-threonyl-tRNA(Thr). Editing is probably catalyzed by the 2'-OH of A76 of tRNA(Thr) (By similarity); Belongs to the class-II aminoacyl-tRNA synthetase family. Archae [...] (386 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | SSO0377 | Conserved hypothetical protein. (172 aa) |
| | SSO0370 | Conserved hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (292 aa) |
| | SSO0367 | ABC transporter, ATP binding protein; Transport. (202 aa) |
| | glnA-1 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-1); Amino Acid Biosynthesis, Glutamate. (471 aa) |
| | folE | GTP cyclohydrolase I (folE); Purines. (208 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (308 aa) |
| | srpR | Signal recognition particle protein (docking protein) (srpR); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (266 aa) |
| | alaS | Alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (900 aa) |
| | thiI | Thiamine biosynthesis protein thiI (thiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (371 aa) |
| | SSO0317 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (361 aa) |
| | SSO0313 | DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases. (550 aa) |
| | aroK | Conserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa) |
| | SSO0287 | RNase L inhibitor; Central Intermediary Metabolism, RNA modification. (600 aa) |
| | thsB | Thermosome subunit beta; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. (557 aa) |
| | hisS | Histidyl-tRNA synthetase (hisS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-II aminoacyl-tRNA synthetase family. (426 aa) |
| | pan | AAA family ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome as [...] (393 aa) |
| | hflX | GTP-binding protein (hflX); GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (356 aa) |
| | tiaS | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (443 aa) |
| | cdc6-1 | Cell division control 6/orc1 protein homolog (cdc6-1); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and strongly inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Stimulates the DNA-binding activity of Cdc6-3. Belongs to the CDC6/cdc18 family. (397 aa) |
| | SSO0255 | Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides. (117 aa) |
| | radA | DNA repair protein radA (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (324 aa) |
| | purA | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | gatB-1 | Glutamyl-tRNA -Gln amidotransferase, subunit B (gatB-1); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (458 aa) |
| | upP | Uracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | infB | Translation initiation factor IF2 homolog (infB); Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (600 aa) |
| | tuF-1 | Elongation factor 1-alpha (elongation factor tu) (EF-tu) (tuF-1); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (435 aa) |
| | SSO0212 | Conserved hypothetical protein; Similarity with MJ0227, MTH743, PAB0313,APE1715, PH1702. (298 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa) |
| | maT | S-adenosylmethionine synthetase (maT); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (410 aa) |
| | SSO0197 | Conserved hypothetical protein; Similarity with APE1602,AF2426, MJ1073, PAB1013, PH0512. (287 aa) |
| | lig | DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (601 aa) |
| | SSO0176 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. (769 aa) |
| | aspS | Aspartyl-tRNA synthetase (aspS); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (429 aa) |
| | SSO0167 | Methyl coenzyme M reductase system, component A2 homolog; Cellular Processes. (373 aa) |
| | rimK-1 | Ribosomal protein S6 modification protein (rimK-1); Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma- carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily. (286 aa) |
| | argB | Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | SSO0152 | Hypothetical protein. (600 aa) |
| | SSO0128 | Iron (III) ABC transporter, periplasmic-binding protein, putative; Transport. (273 aa) |
| | SSO0115 | Hypothetical protein. (194 aa) |
| | SSO0112 | Lhr-like protein; Helicases; Belongs to the helicase family. (875 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta subunit (pheT); Translation, Aminoacyl tRNA synthetases. (544 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha subunit (pheS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (468 aa) |
| | gltX | Glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (575 aa) |
| | lysS | Lysyl-tRNA synthetase (lysS); Translation, Aminoacyl tRNA synthetases. (494 aa) |
| | tyrS | Tyrosyl-tRNA synthetase (tyrS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (366 aa) |
| | SSO0064 | Conserved hypothetical protein. (241 aa) |
| | SSO0053 | ABC transporter, ATP binding protein; Transport. (246 aa) |
| | hypE | Hydrogenase expression/formation protein (hypE); Translation, Protein modification. (343 aa) |
