STRINGSTRING
rbsK-1 rbsK-1 dfp dfp SSO0234 SSO0234 tkt-1 tkt-1 tkt-2 tkt-2 aroE aroE aroD aroD apgM apgM pgk pgk gap gap acaB-1 acaB-1 SSO0535 SSO0535 ilvB-2 ilvB-2 hdb-1 hdb-1 paaF-2 paaF-2 ppsA-1 ppsA-1 eno eno pyK pyK SSO1025 SSO1025 fdhF-1 fdhF-1 fabG-2 fabG-2 SSO10784 SSO10784 porD-2 porD-2 acd-1 acd-1 SSO1154 SSO1154 acd-like1 acd-like1 SSO1157 SSO1157 porG-1 porG-1 paaF-3 paaF-3 SSO1312 SSO1312 SSO1313 SSO1313 acsA-1 acsA-1 aceB/mas aceB/mas acsA-2 acsA-2 acsA-2-2 acsA-2-2 SSO1345 SSO1345 pdhA-1 pdhA-1 pdhB-1 pdhB-1 pdhA-2 pdhA-2 pdhB-2 pdhB-2 SSO1531 SSO1531 SSO1537 SSO1537 SSO1567 SSO1567 alkK-1 alkK-1 acd-2 acd-2 pepQ-like1 pepQ-like1 acsA-3 acsA-3 paaF-4 paaF-4 SSO2018 SSO2018 SSO2019 SSO2019 acsA-4 acsA-4 acsA-4-2 acsA-4-2 pepQ-like2 pepQ-like2 acsA-5 acsA-5 hpaA hpaA acsA-6 acsA-6 acd-3 acd-3 acaB-2 acaB-2 acaB-3 acaB-3 iorB iorB acsA-7 acsA-7 porD-like porD-like idh idh acsA-8 acsA-8 SSO2236 SSO2236 SSO2287 SSO2287 SSO2310 SSO2310 acaB-4 acaB-4 panB panB mcmA1 mcmA1 rbsK-2 rbsK-2 SSO2464 SSO2464 acaB-5 acaB-5 acd-like2 acd-like2 abfD-1 abfD-1 acaB-6 acaB-6 alkK-2 alkK-2 acd-4 acd-4 SSO2514 SSO2514 SSO2515 SSO2515 SSO2519 SSO2519 hpcE-1 hpcE-1 fadD-2 fadD-2 pepQ-like3 pepQ-like3 pckG pckG SSO2586 SSO2586 prpB prpB tpiA tpiA paaF-6 paaF-6 paaF-7 paaF-7 acaB-7 acaB-7 SSO2627 SSO2627 acaB-8 acaB-8 SSO2720 SSO2720 abfD-2 abfD-2 porG-2 porG-2 acd-5 acd-5 hpcE-2 hpcE-2 alkK-3 alkK-3 SSO2815 SSO2815 SSO2816 SSO2816 fdhF-2 fdhF-2 SSO2832 SSO2832 acsA-9 acsA-9 hdb-2 hdb-2 acaB-9 acaB-9 alkK-4 alkK-4 acd-6 acd-6 SSO2940 SSO2940 hpcE-3 hpcE-3 hdb-3 hdb-3 fadD-3 fadD-3 acaB-10 acaB-10 SSO3130 SSO3130 SSO3132 SSO3132 SSO3136 SSO3136 lipA lipA glcD glcD SSO3191 SSO3191 gad gad acsA-10 acsA-10 SSO3226 SSO3226 porD-1 porD-1 acsA-3-2 acsA-3-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rbsK-1Ribokinase (rbsK-1); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (293 aa)
dfpDNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa)
SSO0234Hypothetical protein. (180 aa)
tkt-1Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa)
tkt-2Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa)
aroEShikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa)
aroD3-dehydroquinate dehydratase, putative (aroD); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (220 aa)
apgMPhosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa)
pgkPhosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
acaB-1Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. (359 aa)
SSO0535Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa)
ilvB-2Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa)
hdb-13-hydroxyacyl-CoA dehydrogenase (hdb-1); Lipid metabolism. (324 aa)
paaF-2Enoyl CoA hydratase (paaF-2); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (252 aa)
ppsA-1Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa)
pyKPyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa)
SSO1025Conserved hypothetical protein. (213 aa)
fdhF-1Formate dehydrogenase Alpha subunit (fdhF-1); Energy Metabolism. (657 aa)
fabG-23-oxoacyl-(acyl carrier protein) reductase (fabG-2); Lipid metabolism; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
SSO10784CoA-ligase / coenzyme F390 synthetase, putative; N-terminal fragment. Frameshift with SSO2627; Cofactor Biosynthesis. (84 aa)
porD-2Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa)
acd-1Acyl-CoA dehydrogenase (acd-1); Lipid metabolism. (363 aa)
SSO1154Monoamine oxidase regulatory protein; Uncategorized. (163 aa)
acd-like1Acyl-CoA dehydrogenase related protein (acd-like1); Lipid metabolism. (266 aa)
SSO1157Conserved hypothetical protein. (213 aa)
porG-1Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa)
paaF-3Enoyl CoA hydratase (paaF-3); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
SSO1312Ring oxydation complex/ phenylacetic acid degradation related protein; Cellular Processes, Detoxification. (261 aa)
SSO1313Ring oxydation complex/ phenylacetic acid degradation related protein; Cellular Processes, Detoxification. (234 aa)
acsA-1Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-1); Lipid metabolism. (529 aa)
aceB/masMalate synthase, putative (aceB/mas); Energy Metabolism, Tri-Carboxylic Acid Cycle. (826 aa)
acsA-2Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa)
acsA-2-2Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa)
SSO1345Conserved hypothetical protein; Similar to Ta0751. (257 aa)
pdhA-1Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-1); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (345 aa)
pdhB-1Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-1); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa)
pdhA-2Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-2); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa)
pdhB-2Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-2); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (324 aa)
SSO1531Alkyldihydroxyacetonephosphate synthase (precursor); Lipid metabolism. (451 aa)
SSO1537Conserved hypothetical protein. (269 aa)
SSO1567Conserved hypothetical protein; Metallo-beta-lactamase-related protein. (233 aa)
alkK-1Medium-chain-fatty-acid--CoA ligase (alkK-1); Lipid metabolism. (475 aa)
acd-2Acyl-CoA dehydrogenase (acd-2); Lipid metabolism. (516 aa)
pepQ-like1Prolidase (Xaa-Pro dipeptidase) (pepQ-like1); Similar to novel type M. esteraromaticum prolidase; Proteases. (396 aa)
acsA-3Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Carboxy-end is SSO9201; Lipid metabolism. (457 aa)
paaF-4Enoyl CoA hydratase (paaF-4); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa)
SSO2018Ring oxydation complex/ phenylacetic acid degradation related protein; Cellular Processes, Detoxification. (256 aa)
SSO2019Ring oxydation complex/ phenylacetic acid degradation related protein; Cellular Processes, Detoxification. (234 aa)
acsA-4Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment (acsA-4); Possible frameshift with SSO2021; Lipid metabolism. (288 aa)
acsA-4-2Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment (acsA-4); Possible frameshift with SSO2020 and SSO9518; Lipid metabolism. (267 aa)
pepQ-like2Prolidase (Xaa-Pro dipeptidase) (pepQ-like2); Similar to novel type prolidase from A. esteraromaticum; Proteases. (408 aa)
acsA-5Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa)
hpaA4-hydroxyphenylacetate-3-hydroxylase (hpaA); Central Intermediary Metabolism. (508 aa)
acsA-6Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa)
acd-3Acyl-CoA dehydrogenase (acd-3); Lipid metabolism. (371 aa)
acaB-2Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-2); Lipid metabolism. (381 aa)
acaB-3Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-3); Lipid metabolism. (409 aa)
iorBIndolepyruvate ferredoxin oxidoreductase beta subunit (iorB); Energy Metabolism. (194 aa)
acsA-7Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa)
porD-likePyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa)
idhIsocitrate dehydrogenase, probable (idh); Energy Metabolism, Tri-Carboxylic Acid Cycle. (413 aa)
acsA-8Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa)
SSO2236Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa)
SSO2287Probable acyl-coenzyme a thioester hydrolase; Lipid metabolism. (318 aa)
SSO2310Conserved hypothetical protein; Best hits: APE2265, TM0607. (272 aa)
acaB-4Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-4); Lipid metabolism. (397 aa)
panBKetopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa)
mcmA1Methylmalonyl-CoA mutase, alpha-subunit, chain A (mcmA1); Highly conserved with Pyrococcus and Archaeoglobus; Cellular Processes, Detoxification. (561 aa)
rbsK-2Ribokinase (rbsK-2); Energy Metabolism. (283 aa)
SSO2464Biotin carboxyl carrier protein of propionyl-CoA carboxylase beta subunit; Lipid metabolism. (186 aa)
acaB-5Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-5); Lipid metabolism. (395 aa)
acd-like2Acyl-CoA dehydrogenase related protein (acd-like2); Lipid metabolism. (299 aa)
abfD-14-hydroxybutyryl-CoA dehydratase (abfD-1); Amino Acid Biosynthesis. (463 aa)
acaB-6Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-6); Lipid metabolism. (380 aa)
alkK-2Medium-chain-fatty-acid--CoA ligase (alkK-2); Lipid metabolism. (552 aa)
acd-4Acyl-CoA dehydrogenase (acd-4); Lipid metabolism. (370 aa)
SSO2514Contains 3-Hydroxyacyl-CoA dehydrogenase domain at amino terminus and Enoyl CoA hydratase domain at carboxy terminus; Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (663 aa)
SSO2515Conserved hypothetical protein; Similarity with AF0534, APE2585, APE0330, AF2148. (310 aa)
SSO2519Cyclase/dehydrase, putative; Cellular Processes. (308 aa)
hpcE-12-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1); Central Intermediary Metabolism. (318 aa)
fadD-2Long-chain-fatty-acid--CoA ligase (fadD-2); Lipid metabolism. (559 aa)
pepQ-like3Prolidase (Xaa-Pro dipeptidase) (pepQ-like3); Similar to novel type prolidase from A. esteraromaticum; Proteases. (407 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (603 aa)
SSO2586Conserved hypothetical protein; Belongs To The MMGE / PRPD family. Similar to APE2147. (435 aa)
prpBCarboxyphosphonoenolpyruvate phosphonomutase (CPEP Phosphonomutase), putative (prpB); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (285 aa)
tpiATriosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa)
paaF-6Enoyl CoA hydratase (paaF-6); Lipid metabolism. (249 aa)
paaF-7Enoyl CoA hydratase (paaF-7); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa)
acaB-7Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-7); Lipid metabolism. (387 aa)
SSO2627CoA-ligase / coenzyme F390 synthetase, putative; C-terminal fragment. Frameshift with SSO10784; Cofactor Biosynthesis. (339 aa)
acaB-8Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-8); Lipid metabolism. (376 aa)
SSO2720Aminotransferase; Amino Acid Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
abfD-24-hydroxybutyryl-CoA dehydratase (abfD-2); Amino Acid Biosynthesis. (502 aa)
porG-2Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa)
acd-5Acyl-CoA dehydrogenase (acd-5); Lipid metabolism. (398 aa)
hpcE-22-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-2); Central Intermediary Metabolism. (304 aa)
alkK-3Medium-chain-fatty-acid--CoA ligase (alkK-3); Lipid metabolism. (507 aa)
SSO28152-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa)
SSO28162-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa)
fdhF-2Formate dehydrogenase Alpha subunit (fdhF-2); Energy Metabolism. (979 aa)
SSO2832Conserved hypothetical protein. (233 aa)
acsA-9Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa)
hdb-23-hydroxyacyl-CoA dehydrogenase (hdb-2); Lipid metabolism. (370 aa)
acaB-9Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-9); Lipid metabolism. (395 aa)
alkK-4Medium-chain-fatty-acid--CoA ligase (alkK-4); Lipid metabolism. (537 aa)
acd-6Acyl-CoA dehydrogenase (acd-6); Lipid metabolism. (400 aa)
SSO2940Hypothetical protein. (235 aa)
hpcE-32-hydroxyhepta-2, 4-diene-1,7-dioate isomerase (hpcE-3); Central Intermediary Metabolism. (288 aa)
hdb-33-hydroxyacyl-CoA dehydrogenase (hdb-3); Lipid metabolism. (384 aa)
fadD-3Long-chain-fatty-acid--CoA ligase (fadD-3); Lipid metabolism. (513 aa)
acaB-10Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-10); Lipid metabolism. (385 aa)
SSO3130Iron-sulfur protein, conserved putative; Energy Metabolism. (384 aa)
SSO3132Conserved hypothetical protein; COG0491: Zn-dependent hydrolases, including glyoxylases. (209 aa)
SSO3136Regulatory protein, putative; Resembles Monoamine oxidase regulatory protein; Regulation. (161 aa)
lipALipoic acid synthetase (lipoate synthase) (lipA); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. (285 aa)
glcDGlycolate oxidase glcD subunit. (glcD); Energy Metabolism. (467 aa)
SSO3191Formate dehydrogenase (Amino end fragment); Probable frameshift; Energy Metabolism. (370 aa)
gadMuconate cycloisomerase related protein; Involved in the degradation of glucose and galactose via the branched variant of the Entner-Doudoroff pathway. Catalyzes the dehydration of gluconate to produce 2-keto-3-deoxygluconate (KDG). It is also able to catalyze the dehydration of galactonate to produce 2- keto-3-deoxygalactonate (KDGal); Belongs to the mandelate racemase/muconate lactonizing enzyme family. GaD subfamily. (395 aa)
acsA-10Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa)
SSO3226Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa)
porD-1Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa)
acsA-3-2Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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