STRINGSTRING
SSO0017 SSO0017 ntH-1 ntH-1 rad2 rad2 lig lig radA radA SSO0313 SSO0313 sod sod hjc hjc eiF4A eiF4A rfc rfc radA-like radA-like SSO0872 SSO0872 ogG ogG hje hje msr msr SSO1739 SSO1739 SSO1994 SSO1994 SSO2156 SSO2156 nurA nurA rad50 rad50 rad32/mre11 rad32/mre11 herA herA udg1 udg1 SSO2277 SSO2277 Xth Xth SSB SSB rnhB rnhB dpo4 dpo4 nfi nfi hel308 hel308 phrB phrB ntH-2 ntH-2 ogt ogt SSO2733 SSO2733 SSO2743 SSO2743 SSO2744 SSO2744
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSO0017Lhr-like protein; Helicases. (739 aa)
ntH-1DNA endonuclease III, probable (ntH-1); Replication and Repair. (236 aa)
rad2DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...] (302 aa)
ligDNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (601 aa)
radADNA repair protein radA (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (324 aa)
SSO0313DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases. (550 aa)
sodSuperoxide dismutase [Fe] (sod); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (211 aa)
hjcHolliday-junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'- terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. T [...] (143 aa)
eiF4ARNA helicase (ATP dependent)/eIF4A (eiF4A); A structure-specific endonuclease, cleaves 5' of ds/ssDNA interfaces in 3' flap structures, although it also cuts bubble, Y-DNA structures and mobile and immobile Holliday junctions. Cuts preferentially after pyrimidines, may continue to progressively cleave substrate upstream of the initial cleavage, at least in vitro. May be involved in nucleotide excision repair. (233 aa)
rfcActivator 1, replication factor C, small subunit (rfc); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity; Belongs to the activator 1 small subunits family. RfcS subfamily. (330 aa)
radA-likeDNA repair protein radA homolog (radA-like); Bacterial RadA-like (related to bacterial sequences); Replication and Repair. (175 aa)
SSO0872Conserved hypothetical protein; Involved in DNA damage repair. (408 aa)
ogG8-oxoguanine DNA glycosylase (ogG); Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites); Belongs to the type-2 OGG1 family. (207 aa)
hjeHolliday-junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Acts only on 4-way DNA junctions in a sequence non-specific manner; introduces paired nicks in opposing strands 2 bases 3' of the point of strand exchange only on continuous strands of 4-way junction DNA. Cleaves both mobile and immobile junctions; Belongs to the Holliday junction resolvase Hjc family. Hje subfamily. (135 aa)
msrPeptide methionine sulfoxide reductase (msr); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (177 aa)
SSO1739Conserved hypothetical protein. (315 aa)
SSO1994Conserved hypothetical protein; Putative ATPase. (328 aa)
SSO2156Endonuclease IV related protein; Replication and Repair. (283 aa)
nurAConserved hypothetical protein; Involved in DNA double-strand break (DSB) repair. Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Processes linear dsDNA probes with 3' or 5' single-stranded overhangs or blunt ends. (339 aa)
rad50Purine NTPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (864 aa)
rad32/mre11DNA repair protein (rad32/mre11); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (381 aa)
herAConserved hypothetical protein; Involved in DNA double-strand break (DSB) repair. Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity. Belongs to the HerA family. (500 aa)
udg1DNA polymerase phage SPO1 N-terminal domain homolog; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. (216 aa)
SSO2277Conserved hypothetical protein. (495 aa)
XthExodeoxyribonuclease; Replication and Repair. (247 aa)
SSBSingle-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. (148 aa)
rnhBRibonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (212 aa)
dpo4DNA polymerase IV (family Y) (dpo4); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. (352 aa)
nfiEndonuclease V (nfi); DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (198 aa)
hel308DNA helicase related protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (715 aa)
phrBDeoxyribodipyrimidine photolyase (DNA photolyase) (photoreactivating enzyme). (phrB); Replication and Repair; Belongs to the DNA photolyase family. (433 aa)
ntH-2DNA endonuclease III (ntH-2); Replication and Repair. (227 aa)
ogtMethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (151 aa)
SSO2733Conserved hypothetical protein; Possibly an uracil-DNA glycosylase (COG1573). (219 aa)
SSO2743Conserved hypothetical protein; Involved in DNA damage repair. (397 aa)
SSO2744Conserved hypothetical protein. (261 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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