STRINGSTRING
acd-like1 acd-like1 acd-1 acd-1 porD-2 porD-2 purK purK purE purE prs prs pyrH pyrH ribK ribK carB carB carA carA purM purM purD purD purF-2 purF-2 purF-1 purF-1 purL purL purQ purQ purC purC pyrF pyrF pyrE pyrE pyrB pyrB pyrC pyrC pyrD pyrD ilvB-2 ilvB-2 atpD atpD atpB atpB atpA atpA atpE atpE atpF atpF SSO0429 SSO0429 SSO0416 SSO0416 tkt-2 tkt-2 tkt-1 tkt-1 purA purA cyaB cyaB SSO0241 SSO0241 purB purB purP purP SSO0233 SSO0233 upP upP ndk ndk dfp dfp pyrG pyrG purT purT porD-1 porD-1 acsA-3-2 acsA-3-2 purS purS atpG atpG guaA-2 guaA-2 acsA-10 acsA-10 acd-6 acd-6 acsA-9 acsA-9 SSO2816 SSO2816 SSO2815 SSO2815 acd-5 acd-5 porG-2 porG-2 acd-4 acd-4 acd-like2 acd-like2 guaA guaA gpT-2 gpT-2 panB panB SSO2399 SSO2399 SSO2397 SSO2397 gpT-1 gpT-1 acsA-8 acsA-8 porD-like porD-like acsA-7 acsA-7 iorB iorB acd-3 acd-3 acsA-6 acsA-6 pdhB-2 pdhB-2 pdhA-2 pdhA-2 pdhB-1 pdhB-1 pdhA-1 pdhA-1 acsA-2-2 acsA-2-2 acsA-2 acsA-2 porG-1 porG-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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acd-like1Acyl-CoA dehydrogenase related protein (acd-like1); Lipid metabolism. (266 aa)
acd-1Acyl-CoA dehydrogenase (acd-1); Lipid metabolism. (363 aa)
porD-2Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
prsRibose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa)
pyrHUridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa)
ribKHypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa)
carBCarbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa)
carACarbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa)
purDPhosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa)
purF-2Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa)
purF-1Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa)
purLPhosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa)
purQPhosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa)
pyrEOrotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa)
pyrBAspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa)
pyrCDihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa)
pyrDDihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa)
ilvB-2Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa)
atpDATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa)
atpBATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa)
atpAATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa)
atpEATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa)
atpFATP synthase subunit F (atpF); Energy Metabolism, ATP-Proton Motive Force. (100 aa)
SSO0429Hypothetical protein. (326 aa)
SSO0416Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa)
tkt-2Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa)
tkt-1Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa)
purAAdenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa)
cyaBAdenylate cyclase, cyaB-type, putative (cyaB); Cellular Processes, Purines. (186 aa)
SSO0241Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa)
purBAdenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa)
purPConserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa)
SSO0233Conserved hypothetical protein; Seems related to pur operon repressor. Similar to PH1691, PAB2035, APE0060. (246 aa)
upPUracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
ndkNucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa)
dfpDNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa)
pyrGCTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa)
purTPhosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa)
porD-1Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa)
acsA-3-2Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa)
purSConserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa)
atpGATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa)
guaA-2GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa)
acsA-10Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa)
acd-6Acyl-CoA dehydrogenase (acd-6); Lipid metabolism. (400 aa)
acsA-9Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa)
SSO28162-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa)
SSO28152-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa)
acd-5Acyl-CoA dehydrogenase (acd-5); Lipid metabolism. (398 aa)
porG-2Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa)
acd-4Acyl-CoA dehydrogenase (acd-4); Lipid metabolism. (370 aa)
acd-like2Acyl-CoA dehydrogenase related protein (acd-like2); Lipid metabolism. (299 aa)
guaAGMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa)
gpT-2Purine phosphoribosyltransferase (gpT-2); Similar to APE2071 and PAB0060; Purines. (179 aa)
panBKetopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa)
SSO2399Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa)
SSO2397Conserved hypothetical protein. (271 aa)
gpT-1Purine phosphoribosyltransferase (gpT-1); Purines. (210 aa)
acsA-8Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa)
porD-likePyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa)
acsA-7Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa)
iorBIndolepyruvate ferredoxin oxidoreductase beta subunit (iorB); Energy Metabolism. (194 aa)
acd-3Acyl-CoA dehydrogenase (acd-3); Lipid metabolism. (371 aa)
acsA-6Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa)
pdhB-2Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-2); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (324 aa)
pdhA-2Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-2); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa)
pdhB-1Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-1); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa)
pdhA-1Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-1); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (345 aa)
acsA-2-2Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa)
acsA-2Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa)
porG-1Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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