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| | acoX | Acetoin catabolism protein X homolog (acoX); Unknown function in acoXABC operon; Energy Metabolism. (339 aa) |
| | moaB | Cofactor Biosynthesis, Molybdopterin. (182 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | gdS-1 | Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family. (332 aa) |
| | cinA | Competence damage protein (cinA); Regulation; Belongs to the CinA family. (272 aa) |
| | dcD-1 | Deoxycytidine triphosphate deaminase (dcD-1); Catalyzes the deamination of dCTP to dUTP. (206 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | upP | Uracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | SSO0233 | Conserved hypothetical protein; Seems related to pur operon repressor. Similar to PH1691, PAB2035, APE0060. (246 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | purB | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | purA | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | cyaB | Adenylate cyclase, cyaB-type, putative (cyaB); Cellular Processes, Purines. (186 aa) |
| | SSO0255 | Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides. (117 aa) |
| | SSO0259 | Conserved hypothetical protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (255 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | thyX | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (260 aa) |
| | SSO0330 | Conserved hypothetical protein. (344 aa) |
| | thiI | Thiamine biosynthesis protein thiI (thiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (371 aa) |
| | SSO0354 | Nicotinic acid phosphoribosyltransferase, putative; Cofactor Biosynthesis, Pyridine nucleotides. (387 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A (moaA); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (308 aa) |
| | folE | GTP cyclohydrolase I (folE); Purines. (208 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | SSO0416 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa) |
| | SSO0429 | Hypothetical protein. (326 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (267 aa) |
| | SSO0461 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (187 aa) |
| | SSO0535 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa) |
| | acsA-3-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-3); Interrupted by ISC1439 transposase. Amino-end is SSO1903; Lipid metabolism. (74 aa) |
| | porD-1 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | atpG | ATP synthase subunit G (atpG); Energy Metabolism, ATP-Proton Motive Force. (52 aa) |
| | guaA-2 | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | MvaD | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. (325 aa) |
| | SSO2988 | (Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa) |
| | dcD-2 | Deoxycytidine triphosphate deaminase (dcD-2); Pyrimidines. (166 aa) |
| | acd-6 | Acyl-CoA dehydrogenase (acd-6); Lipid metabolism. (400 aa) |
| | SSO2865 | Hypothetical protein. (104 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | fdhD | FDHD protein homolog (fdhD); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (257 aa) |
| | fixC | FIXC protein homolog (fixC); Dehydrogenase (flavoprotein); Energy Metabolism. (395 aa) |
| | SSO2816 | 2-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa) |
| | SSO2815 | 2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa) |
| | SSO2776 | Electron transfert oxidoreductase; Energy Metabolism, Electron transport. (407 aa) |
| | acd-5 | Acyl-CoA dehydrogenase (acd-5); Lipid metabolism. (398 aa) |
| | porG-2 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa) |
| | SSO2634 | Conserved hypothetical protein. (140 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa) |
| | acd-4 | Acyl-CoA dehydrogenase (acd-4); Lipid metabolism. (370 aa) |
| | nrdB | Ribonucleotide reductase small subunit, probable (nrdB); Purines. (308 aa) |
| | acd-like2 | Acyl-CoA dehydrogenase related protein (acd-like2); Lipid metabolism. (299 aa) |
| | guaA | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | gpT-2 | Purine phosphoribosyltransferase (gpT-2); Similar to APE2071 and PAB0060; Purines. (179 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (204 aa) |
| | panB | Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa) |
| | SSO2399 | Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa) |
| | SSO2397 | Conserved hypothetical protein. (271 aa) |
| | moaE | Cofactor Biosynthesis, Molybdopterin. (231 aa) |
| | moeA-2 | Cofactor Biosynthesis, Molybdopterin. (550 aa) |
| | SSO2353 | Geranylgeranyl hydrogenase, putative; Lipid metabolism. (398 aa) |
| | SSO2348 | Geranylgeranyl hydrogenase, putative; Best hit: AF0464; Lipid metabolism. (332 aa) |
| | gpT-1 | Purine phosphoribosyltransferase (gpT-1); Purines. (210 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (249 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | nadE | NH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa) |
| | SSO2171 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (175 aa) |
| | SSO2151 | Conserved hypothetical protein; Similarity with aq_477. (113 aa) |
| | porD-like | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | iorB | Indolepyruvate ferredoxin oxidoreductase beta subunit (iorB); Energy Metabolism. (194 aa) |
| | acd-3 | Acyl-CoA dehydrogenase (acd-3); Lipid metabolism. (371 aa) |
| | acsA-6 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-6); Lipid metabolism. (622 aa) |
| | thiC-2 | Thiamine biosynthesis protein (thiC-2); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | pdhB-2 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-2); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (324 aa) |
| | pdhA-2 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-2); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | pdhB-1 | Pyruvate dehydrogenase, beta subunit (lipoamide). (pdhB-1); Strong similarity to acetoin:DCPIP oxidoreductase-beta (acoB) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (332 aa) |
| | pdhA-1 | Pyruvate dehydrogenase, alpha subunit (lipoamide). (pdhA-1); Strong similarity to acetoin:DCPIP oxidoreductase-alpha (acoA) gene from R. eutropha; Energy Metabolism, Dehydrogenases. (345 aa) |
| | acsA-2-2 | Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Carboxy-end is SSO1340; Lipid metabolism. (287 aa) |
| | acsA-2 | Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2); Interrupted by transposase in ISC1316. Amino-end is SSO1342; Lipid metabolism. (260 aa) |
| | thiC-1 | Thiamine biosynthesis protein (thiC-1); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | porG-1 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa) |
| | tmK-2 | Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa) |
| | tmk | Thymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa) |
| | acd-like1 | Acyl-CoA dehydrogenase related protein (acd-like1); Lipid metabolism. (266 aa) |
| | acd-1 | Acyl-CoA dehydrogenase (acd-1); Lipid metabolism. (363 aa) |
| | porD-2 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | nadA | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (311 aa) |
| | nadB | Aspartate oxidase (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate. (487 aa) |
| | NadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (275 aa) |
| | pyrH | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa) |
| | ribK | Hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (175 aa) |
| | SSO0898 | Conserved hypothetical protein. (331 aa) |
| | SSO0886 | Conserved hypothetical protein. (360 aa) |
| | SSO0869 | Conserved hypothetical protein; Similarity with SSO1527. (356 aa) |
| | tmK-1 | Thymidylate kinase (tmK-1); Pyrimidines. (189 aa) |
| | carS | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (166 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C (moaC); Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (149 aa) |
| | gldA | Glycerol-1-phosphate dehydrogenase (gldA); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (351 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | cmK | Cytidylate kinase (cmK); Pyrimidines. (189 aa) |
| | mobA | Molybdopterin guanine dinucleotide biosynthesis; Cofactor Biosynthesis, Molybdopterin. (194 aa) |
| | moeA-1 | Cofactor Biosynthesis, Molybdopterin. (389 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B (mobB); Cofactor Biosynthesis, Molybdopterin. (169 aa) |
| | SSO0648 | Hypothetical protein. (178 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purF-2 | Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa) |
| | purF-1 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa) |
| | SSO0612 | Hypothetical protein. (208 aa) |
| | pyrC | Dihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa) |
| | pyrD | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa) |
| | SSO0584 | Conserved hypothetical protein. (290 aa) |
| | ubiA-2 | 4-hydroxybenzoate octaprenyltransferase, putative (ubiA-2); Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use other prenyl donors, i.e. farnesyl diphosphate (FPP) and phytyl diphosphate. Moreover, 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate, and alpha-glycerophosphate do not function as prenyl acceptor substrates. (282 aa) |
| | ilvB-2 | Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa) |
| | pdxT | Glutamine amidotransferase, putative; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa) |
| | pdxS | Ethylene-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (338 aa) |
| | atpD | ATP synthase subunit D (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | atpB | ATP synthase subunit B (atpB); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpA | ATP synthase subunit A (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (592 aa) |
| | atpE | ATP synthase subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane. (194 aa) |
| | atpF | ATP synthase subunit F (atpF); Energy Metabolism, ATP-Proton Motive Force. (100 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putataive (pgsA); Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea. (195 aa) |
