(4 nodes) (2020) Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. network (Saccharolobus solfataricus)

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	pcnA-1	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc. (259 aa)
	SSO0313	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases. (550 aa)
	rad2	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...] (302 aa)
	dpo3	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair. (764 aa)

Your Current Organism:

Saccharolobus solfataricus

NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SSO0313	dpo3	SSO0313	SSO0081	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	0.723
SSO0313	pcnA-1	SSO0313	SSO0405	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.687
SSO0313	rad2	SSO0313	SSO0179	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.953
dpo3	SSO0313	SSO0081	SSO0313	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	0.723
dpo3	pcnA-1	SSO0081	SSO0405	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.953
dpo3	rad2	SSO0081	SSO0179	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.930
pcnA-1	SSO0313	SSO0405	SSO0313	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	0.687
pcnA-1	dpo3	SSO0405	SSO0081	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	0.953
pcnA-1	rad2	SSO0405	SSO0179	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.996
rad2	SSO0313	SSO0179	SSO0313	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	DNA helicase; Similar to CHL1 (S.cerevisiae). Belongs to the RAD3/XPD subfamily of helicases; Helicases, Helicases.	0.953
rad2	dpo3	SSO0179	SSO0081	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3); Replication and Repair.	0.930
rad2	pcnA-1	SSO0179	SSO0405	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.996