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pmM pmM fbp fbp apgM apgM pgk pgk gap gap ppsA-1 ppsA-1 eno eno pyK pyK porD-2 porD-2 pdhD-1 pdhD-1 porB-1 porB-1 porG-1 porG-1 pdhD-2 pdhD-2 pdhC pdhC pdhD-3 pdhD-3 adh-5 adh-5 SSO1806 SSO1806 acsA-5 acsA-5 acsA-7 acsA-7 porD-like porD-like porA-like porA-like porB-like porB-like acsA-8 acsA-8 SSO2236 SSO2236 SSO2281 SSO2281 adh-10 adh-10 pckG pckG pdhD-4 pdhD-4 tpiA tpiA SSO2747 SSO2747 porB-2 porB-2 porA-2 porA-2 porG-2 porG-2 SSO2815 SSO2815 SSO2816 SSO2816 acsA-9 acsA-9 gapN-3 gapN-3 SSO3226 SSO3226 porD-1 porD-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pmMPhosphomannomutase (pmM); Cell Envelope, Surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. (455 aa)
fbpConserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (382 aa)
apgMPhosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa)
pgkPhosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
ppsA-1Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa)
pyKPyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa)
porD-2Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa)
pdhD-1Dihydrolipoamide dehydrogenase (pdhD-1); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (446 aa)
porB-1Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-1); Energy Metabolism. (300 aa)
porG-1Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa)
pdhD-2Dihydrolipoamide dehydrogenase (pdhD-2); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (412 aa)
pdhCDihydrolipoamide S-acetyltransferase, amino-end (pdhC); Probable frameshift with SSO1530; Energy Metabolism. (211 aa)
pdhD-3Dihydrolipoamide dehydrogenase (pdhD-3); Highest hit with Thermoplasma; Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (456 aa)
adh-5Alcohol dehydrogenase (Zn containing) (adh-5); Energy Metabolism. (344 aa)
SSO1806Conserved hypothetical protein. (660 aa)
acsA-5Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa)
acsA-7Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa)
porD-likePyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa)
porA-likePyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-like); Energy Metabolism. (415 aa)
porB-likePyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-like); Energy Metabolism. (338 aa)
acsA-8Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa)
SSO2236Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa)
SSO2281Conserved hypothetical protein; Involved in the synthesis of UDP-N-acetylgalactosamine (UDP- GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P). Belongs to the PGI/PMI family. (296 aa)
adh-10Alcohol dehydrogenase (Zn containing) (adh-10); Energy Metabolism; Belongs to the zinc-containing alcohol dehydrogenase family. (347 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (603 aa)
pdhD-4Dihydrolipoamide dehydrogenase (pdhD-4); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (409 aa)
tpiATriosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa)
SSO2747Conserved hypothetical protein. (262 aa)
porB-2Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-2); Energy Metabolism. (299 aa)
porA-2Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-2); Energy Metabolism. (400 aa)
porG-2Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa)
SSO28152-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa)
SSO28162-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa)
acsA-9Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa)
gapN-3Glyceraldehyde-3-phosphate dehydrogenase, NADP dependent (gapN-3); Catalyzes the irreversible NAD(P)-dependent non- phosphorylating oxidation of glyceraldehyde-3-phosphate (GAP) to 3- phosphoglycerate (3PG). It is highly specific for D-GAP. (509 aa)
SSO3226Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa)
porD-1Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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