STRINGSTRING
purT purT pmM pmM ndk ndk purP purP purB purB SSO0241 SSO0241 purA purA hit hit cyaB cyaB SSO0432 SSO0432 iunH-1 iunH-1 purC purC purQ purQ purL purL purF-1 purF-1 purF-2 purF-2 purD purD purM purM adkA adkA nrd nrd pyK pyK prs prs purE purE purK purK SSO1193 SSO1193 deoD deoD SSO2167 SSO2167 SSO2171 SSO2171 SSO2230 SSO2230 iunH-2 iunH-2 guaA guaA sat sat guaA-2 guaA-2 purS purS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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purTPhosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa)
pmMPhosphomannomutase (pmM); Cell Envelope, Surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. (455 aa)
ndkNucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa)
purPConserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa)
purBAdenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa)
SSO0241Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa)
purAAdenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa)
hitHIT-like protein, hypothetical (hit); HIT family hydrolase; Central Intermediary Metabolism. (171 aa)
cyaBAdenylate cyclase, cyaB-type, putative (cyaB); Cellular Processes, Purines. (186 aa)
SSO0432HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
iunH-1Purine nucleosidase, putative (iunH-1); Purines. (311 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa)
purQPhosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa)
purLPhosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa)
purF-1Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa)
purF-2Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa)
purDPhosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa)
adkAAdenylate kinase (adkA); Purines. (195 aa)
nrdRibonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (841 aa)
pyKPyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa)
prsRibose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa)
SSO1193Exopolyphosphatase (metaphosphatase), putative; Central Intermediary Metabolism. (417 aa)
deoDPurine nucleoside phosporylase (deoD); Purines. (274 aa)
SSO2167Conserved hypothetical protein. (166 aa)
SSO2171Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (175 aa)
SSO2230Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (176 aa)
iunH-2Purine nucleosidase, putative (iunH-2); Very similar to ORF2 from Acidianus ambivalens; Purines. (307 aa)
guaAGMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. (188 aa)
satSulfate adenylyltransferase (sat); Central Intermediary Metabolism, Sulfur. (406 aa)
guaA-2GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. (367 aa)
purSConserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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