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dcD-1 dcD-1 pyrG pyrG ndk ndk upP upP thyX thyX pyrD pyrD pyrC pyrC pyrI pyrI pyrB pyrB pyrE pyrE pyrF pyrF carA carA carB carB cmK cmK nrd nrd pyrH pyrH tmk tmk tmK-2 tmK-2 deoD deoD amaB amaB codA codA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dcD-1Deoxycytidine triphosphate deaminase (dcD-1); Catalyzes the deamination of dCTP to dUTP. (206 aa)
pyrGCTP synthetase (UTP-ammonia lyase) (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity). (535 aa)
ndkNucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa)
upPUracil phosphoribosyltransferase (upP); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
thyXConserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (260 aa)
pyrDDihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (290 aa)
pyrCDihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (390 aa)
pyrIAspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (163 aa)
pyrBAspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa)
pyrEOrotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (222 aa)
carACarbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family. (367 aa)
carBCarbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines. (1051 aa)
cmKCytidylate kinase (cmK); Pyrimidines. (189 aa)
nrdRibonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (841 aa)
pyrHUridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. (227 aa)
tmkThymidylate kinase related protein; Extra end piece is homologous to the ribonuclease T2 family; Pyrimidines. (208 aa)
tmK-2Thymidylate kinase (tmK-2); Hits to other hypothetical sulfolobus TMK and extra end region homology with the ribonuclease T2 family; Pyrimidines. (213 aa)
deoDPurine nucleoside phosporylase (deoD); Purines. (274 aa)
amaBN-carbamoyl-L-amino acid amidohydrolase (amaB); Amino Acid Biosynthesis. (401 aa)
codACytosine deaminase (codA); Pyrimidines. (410 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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