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maT maT SSO0265 SSO0265 metE-1 metE-1 metE-2 metE-2 SpeD SpeD speH speH thrA/hom thrA/hom ahcY ahcY speE speE asd-1 asd-1 akH akH aspB-2 aspB-2 serA-1 serA-1 cysA-1 cysA-1 garD garD SSO1260 SSO1260 cysA-2 cysA-2 mtaP mtaP metB metB sqdB-2 sqdB-2 mtaP-2 mtaP-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
maTS-adenosylmethionine synthetase (maT); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (410 aa)
SSO0265DNA modification methylase, type II R/M system; Cytosine-specific methyltransferase; Replication and Repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (325 aa)
metE-15-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-1); Amino Acid Biosynthesis. (330 aa)
metE-25-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-2); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (332 aa)
SpeDConserved hypothetical protein; Specifically catalyzes the decarboxylation of L-arginine to agmatine. Is also able to decarboxylate L-canavanine, although less efficiently. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (134 aa)
speHConserved hypothetical protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. Has no arginine decarboxylase (ArgDC) activity. Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (124 aa)
thrA/homHomoserine dehydrogenase (thrA/hom); Amino Acid Biosynthesis, Aspartate. (314 aa)
ahcYS-adenosyl-L-homocysteine hydrolase (ahcY); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (442 aa)
speESpermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as putrescine (1,4-diaminobutane), 1,3-diaminopropane, sym- norspermidine and spermidine. The biosynthesis of caldopentamine from norspermine has been also ob [...] (301 aa)
asd-1Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (asd-1); Amino Acid Biosynthesis, Aspartate. (350 aa)
akHAspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa)
aspB-2Aspartate aminotransferase (aspB-2); Amino Acid Biosynthesis, Aspartate. (402 aa)
serA-1D-3-phosphoglycerate dehydrogenase (serA-1); Amino Acid Biosynthesis, Histidine; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
cysA-1Thiosulfate sulfurtransferase (cysA-1); Central Intermediary Metabolism, Sulfur. (278 aa)
garDGalactarate dehydratase, putative (garD); Central Intermediary Metabolism. (387 aa)
SSO1260Conserved hypothetical protein; Similar to Ta1392. Similar to Altronate hydrolase Amino-terminus. (99 aa)
cysA-2Thiosulfate sulfurtransferase (cysA-2); Central Intermediary Metabolism, Sulfur. (293 aa)
mtaP5'-methylthioadenosine phosphorylase (mtaP); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (270 aa)
metBO-succinylhomoserine (thiol)-lyase (cystathionine gamma-synthase) (metB); Amino Acid Biosynthesis. (376 aa)
sqdB-2L-lactate dehydrogenase (sqdB); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (327 aa)
mtaP-25'-methylthioadenosine phosphorylase (mtaP); Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Cleaves inosine, guanosine, and adenosine with a better efficiency than MTA. (236 aa)
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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