10 items (Saccharolobus solfataricus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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gene neighborhood

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Your Input:
	dfp	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. (413 aa)
	SSO0416	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa)
	ilvC-1	Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
	ilvB-2	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa)
	ilvC-3	Ketol-acid reductoisomerase (ilvC-3); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family. (332 aa)
	SSO2397	Conserved hypothetical protein. (271 aa)
	SSO2399	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401). (266 aa)
	panB	Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa)
	ilvD	Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family. (558 aa)
	ilvB-6	Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate. (543 aa)

Your Current Organism:

Saccharolobus solfataricus

NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SSO0416	SSO2397	SSO0416	SSO2397	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	Conserved hypothetical protein.	0.553
SSO0416	SSO2399	SSO0416	SSO2399	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	0.637
SSO2397	SSO0416	SSO2397	SSO0416	Conserved hypothetical protein.	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	0.553
SSO2397	SSO2399	SSO2397	SSO2399	Conserved hypothetical protein.	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	0.996
SSO2397	dfp	SSO2397	SSO0210	Conserved hypothetical protein.	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate.	0.606
SSO2397	panB	SSO2397	SSO2400	Conserved hypothetical protein.	Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.451
SSO2399	SSO0416	SSO2399	SSO0416	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	0.637
SSO2399	SSO2397	SSO2399	SSO2397	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	Conserved hypothetical protein.	0.996
SSO2399	dfp	SSO2399	SSO0210	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate.	0.965
SSO2399	panB	SSO2399	SSO2400	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.454
dfp	SSO2397	SSO0210	SSO2397	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate.	Conserved hypothetical protein.	0.606
dfp	SSO2399	SSO0210	SSO2399	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate.	Conserved hypothetical protein; High hit: APE1937 (conserved link with SS2401).	0.965
dfp	panB	SSO0210	SSO2400	DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate.	Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.752
ilvB-2	ilvB-6	SSO0579	SSO3210	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.	Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate.	0.927
ilvB-2	ilvC-1	SSO0579	SSO0576	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.	Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.993
ilvB-2	ilvC-3	SSO0579	SSO1942	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.	Ketol-acid reductoisomerase (ilvC-3); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family.	0.968
ilvB-2	ilvD	SSO0579	SSO3107	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.	Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family.	0.914
ilvB-6	ilvB-2	SSO3210	SSO0579	Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate.	Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.	0.927
ilvB-6	ilvC-1	SSO3210	SSO0576	Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate.	Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.959
ilvB-6	ilvC-3	SSO3210	SSO1942	Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate.	Ketol-acid reductoisomerase (ilvC-3); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family.	0.958