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| | purT | Phosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (409 aa) |
| | gdS-1 | Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family. (332 aa) |
| | fni | FMN-dependent dehydrogenase, conserved hypothetical; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (368 aa) |
| | SSO0064 | Conserved hypothetical protein. (241 aa) |
| | gltX | Glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (575 aa) |
| | SSO0094 | Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (228 aa) |
| | aspB-1 | Aspartate aminotransferase (aspB-1); Amino Acid Biosynthesis, Aspartate. (401 aa) |
| | ubiA-1 | 4-hydroxybenzoate octaprenyltransferase (ubiA-1); Cofactor Biosynthesis, Quinones. (302 aa) |
| | leuA-1 | 2-isopropylmalate synthase, putative (leuA-1); Amino Acid Biosynthesis, Pyruvate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (553 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase (argC); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (352 aa) |
| | argB | Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | argD | Acetylornithine aminotransferase (argD); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (392 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa) |
| | HemB | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. (341 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase (hemL); Cofactor Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (426 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (293 aa) |
| | SSO0184 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (237 aa) |
| | maT | S-adenosylmethionine synthetase (maT); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (410 aa) |
| | pmM | Phosphomannomutase (pmM); Cell Envelope, Surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. (455 aa) |
| | ndk | Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (138 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (356 aa) |
| | purB | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (474 aa) |
| | SSO0241 | Conserved hypothetical protein; Similar to PAB1272, PH0324, MJ0136, MTH1201,AF0256. (349 aa) |
| | pheA | Probable chorismate mutase (CM)/prephenate dehydratase (PDT) (pheA); Amino Acid Biosynthesis. (269 aa) |
| | tdcB | Threonine dehydratase catabolic (threonine deaminase) (tdcB); Amino Acid Biosynthesis, Aspartate. (405 aa) |
| | fbp | Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (382 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | tyrA | Chorismate mutase/prephenate dehydratase, putative (tyrA); Amino Acid Biosynthesis. (346 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Amino Acid Biosynthesis, Aromatic amino acids. (331 aa) |
| | aroB | 3-dehydroquinate synthase (aroB); Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (354 aa) |
| | aroE | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroC | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | aroK | Conserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | aroD | 3-dehydroquinate dehydratase, putative (aroD); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (220 aa) |
| | SSO0317 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (361 aa) |
| | SSO0330 | Conserved hypothetical protein. (344 aa) |
| | SSO0381 | Sugar phosphate nucleotydyl transferase; Several close hits to other proteins; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (363 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | ribH | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribC | Riboflavin synthase (ribC); Cofactor Biosynthesis, Riboflavin. (155 aa) |
| | ribA | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. (219 aa) |
| | metE-1 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-1); Amino Acid Biosynthesis. (330 aa) |
| | metE-2 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-2); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (332 aa) |
| | apgM | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (209 aa) |
| | hisC-like | Histidinol-phosphate aminotransferase, putative (hisC-like); Amino Acid Biosynthesis, Histidine. (326 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. (433 aa) |
| | hmgA | 3 hydroxy 3 methylglutaryl coenzyme a reductase; Converts HMG-CoA to mevalonate; Belongs to the HMG-CoA reductase family. (409 aa) |
| | acaB-1 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. (359 aa) |
| | SSO0535 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa) |
| | ilvC-1 | Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa) |
| | ilvB-2 | Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa) |
| | hisC | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. (376 aa) |
| | hisG | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. (232 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (251 aa) |
| | hisD | Histidinol dehydrogenase (HDH) (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (398 aa) |
| | hisH | Amidotransferase hisH (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (199 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family. (233 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (224 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] (709 aa) |
| | purF-1 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (450 aa) |
| | purF-2 | Amidophosphoribosyltransferase; Purines; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa) |
| | purD | Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family. (483 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase) (AIRS) (purM); Purines. (323 aa) |
| | argG | Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argH | Argininosuccinate lyase (argH); Amino Acid Biosynthesis, Glutamate. (459 aa) |
| | ctaB | Cytochrome C oxidase folding protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (286 aa) |
| | thrA/hom | Homoserine dehydrogenase (thrA/hom); Amino Acid Biosynthesis, Aspartate. (314 aa) |
| | SSO0666 | Glycerate kinase, putative; Uncategorized. (400 aa) |
| | adkA | Adenylate kinase (adkA); Purines. (195 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (leuB); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (336 aa) |
| | SSO0745 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (407 aa) |
| | argF | Ornithine carbamoyltransferase (argF); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | asd-1 | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (asd-1); Amino Acid Biosynthesis, Aspartate. (350 aa) |
| | akH | Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa) |
| | thrC-2 | Threonine synthase (thrC-2); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (396 aa) |
| | SSO0879 | Conserved hypothetical protein. (488 aa) |
| | ppsA-1 | Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | SSO0886 | Conserved hypothetical protein. (360 aa) |
| | trpB | Tryptophan synthase beta chain (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (425 aa) |
| | trpA | Tryptophan synthase alpha chain (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (245 aa) |
| | trpD | Anthranilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpF | Phosphoribosyl anthranilate isomerase (trpF); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the TrpF family. (204 aa) |
| | trpE | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (421 aa) |
| | trpGD | Anthranilate synthase component II (trpGD); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (195 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (trpC); Amino Acid Biosynthesis, Aromatic amino acids. (248 aa) |
| | aspB-2 | Aspartate aminotransferase (aspB-2); Amino Acid Biosynthesis, Aspartate. (402 aa) |
| | serA-1 | D-3-phosphoglycerate dehydrogenase (serA-1); Amino Acid Biosynthesis, Histidine; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa) |
| | gcvPB | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (508 aa) |
| | gcvPA | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (455 aa) |
| | GcvT | Aminomethyltransferase; Energy Metabolism. (346 aa) |
| | gcvH1 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (137 aa) |
| | SSO0954 | Conserved hypothetical protein. (226 aa) |
| | fabG-1 | 3-oxoacyl-(acyl carrier protein) reductase (fabG-1); Lipid metabolism. (265 aa) |
| | leuA-2 | 2-isopropylmalate synthase (leuA-2); Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. (461 aa) |
| | rpiA | Ribose 5-phosphate isomerase (rpiA); Energy Metabolism. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | SSO0987 | Glycogen synthase; Energy Metabolism, Sugar metabolism. (566 aa) |
| | SSO0988 | Alpha amylase; Energy Metabolism, Sugar metabolism. (447 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | gcvH2 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (148 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (365 aa) |
| | fumC | Fumarate hydratase classe II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate. (445 aa) |
| | AcnA | Aconitate hydratase; Energy Metabolism, Tri-Carboxylic Acid Cycle. (855 aa) |
| | gcvH3 | Glycine cleavage system protein H, hypothetical; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (140 aa) |
| | porD-2 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa) |
| | pdhD-1 | Dihydrolipoamide dehydrogenase (pdhD-1); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (446 aa) |
| | trpB-like | Tryptophan synthase beta chain, hypothetical (trpB-like); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (429 aa) |
| | porB-1 | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-1); Energy Metabolism. (300 aa) |
| | porG-1 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa) |
| | deoD | Purine nucleoside phosporylase (deoD); Purines. (274 aa) |
| | pdhD-2 | Dihydrolipoamide dehydrogenase (pdhD-2); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (412 aa) |
| | pdhC | Dihydrolipoamide S-acetyltransferase, amino-end (pdhC); Probable frameshift with SSO1530; Energy Metabolism. (211 aa) |
| | pdhD-3 | Dihydrolipoamide dehydrogenase (pdhD-3); Highest hit with Thermoplasma; Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (456 aa) |
| | adh-5 | Alcohol dehydrogenase (Zn containing) (adh-5); Energy Metabolism. (344 aa) |
| | tynA | Amine oxidase (copper-containing) (tynA); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the copper/topaquinone oxidase family. (660 aa) |
| | rfbB-2 | dTDP-Glucose 4,6-dehydratase (rfbB-2); Energy Metabolism, Sugar metabolism. (350 aa) |
| | rfbB-3 | dTDP-Glucose 4,6-dehydratase (rfbB-3); Multicopy. Similar to SSO0830, SSO1734; Energy Metabolism, Sugar metabolism. (312 aa) |
| | SSO1782 | Sugar phosphate nucleotydyl transferase; Cell Envelope, Surface polysaccharides and lipopolysaccharides. (344 aa) |
| | rfbD-2 | dTDP-4-dehydrorhamnose reductase (rfbD-2); Cell Envelope, Surface polysaccharides and lipopolysaccharides. (207 aa) |
| | SSO1808 | Ubiquinone/menaquinone biosynthesis methyltransferase; Cofactor Biosynthesis, Quinones. (232 aa) |
| | pqqE-4 | Coenzyme PQQ synthesis protein E (pqqE-4); Multicopy. Similar to SSO1632; Cofactor Biosynthesis, Quinones. (378 aa) |
| | pqqE-5 | Coenzyme PQQ synthesis protein E (pqqE-5); Cofactor Biosynthesis, Quinones. (350 aa) |
| | rfbC-2 | dTDP-4-dehydrorhamnose 3,5 epimerase (rfbC-2); Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (176 aa) |
| | ilvC-3 | Ketol-acid reductoisomerase (ilvC-3); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family. (332 aa) |
| | acsA-5 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa) |
| | acaB-2 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-2); Lipid metabolism. (381 aa) |
| | acaB-3 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-3); Lipid metabolism. (409 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | treZ | Malto-oligosyltrehalose trehalohydrolase (treZ); Energy Metabolism, Sugar metabolism. (561 aa) |
| | treX | Glycogen debranching enzyme (treX); Energy Metabolism, Sugar metabolism. (718 aa) |
| | treY | Maltooligosyltrehalose synthase (treY); Energy Metabolism, Sugar metabolism. (732 aa) |
| | porD-like | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa) |
| | porA-like | Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-like); Energy Metabolism. (415 aa) |
| | porB-like | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-like); Energy Metabolism. (338 aa) |
| | rfbD-3 | dTDP-4-dehydrorhamnose reductase (rfbD-3); Cell Envelope, Surface polysaccharides and lipopolysaccharides. (255 aa) |
| | idh | Isocitrate dehydrogenase, probable (idh); Energy Metabolism, Tri-Carboxylic Acid Cycle. (413 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | SSO2236 | Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa) |
| | dapA-1 | Dihydrodipicolinate synthase (dapA-1); Amino Acid Biosynthesis, Aspartate. (289 aa) |
| | fabG-5 | 3-oxoacyl-(acyl carrier protein) reductase (fabG-5); Lipid metabolism. (261 aa) |
| | SSO2281 | Conserved hypothetical protein; Involved in the synthesis of UDP-N-acetylgalactosamine (UDP- GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P). Belongs to the PGI/PMI family. (296 aa) |
| | gdS-2 | Geranylgeranyl pyrophosphate synthetase, putative (gdS-2); Catalyzes consecutive E-type condensation of two isopentenyl pyrophosphate (IPP) molecules with an allylic substrate such as geranylgeranyl diphosphate (GGPP), farnesyl diphosphate (FPP) or geranyl diphosphate (GPP) to yield the medium-chain product trans-C30- hexaprenyl pyrophosphate (HexPP). GGPP is the physiological substrate. (281 aa) |
| | ansA-like | Asparinase, putative (ansA-like); Amino Acid Biosynthesis, Aspartate. (276 aa) |
| | sdhA | Succinate dehydrogenase subunit A (sdhA); Flavoprotein subunit; Energy Metabolism, Electron transport. (566 aa) |
| | sdhB | Succinate dehydrogenase subunit B (sdhB); Iron-sulfur subunit B; Energy Metabolism, Electron transport. (316 aa) |
| | sdhC | Succinate dehydrogenase subunit C (sdhC); Iron-sulfur subunit C; also hit with htrB2 subunit of heterodisulfide reductase; Energy Metabolism, Electron transport. (293 aa) |
| | sdhD | Succinate dehydrogenase subunit D (sdhD); Subunit D; Energy Metabolism, Electron transport. (121 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa) |
| | metB | O-succinylhomoserine (thiol)-lyase (cystathionine gamma-synthase) (metB); Amino Acid Biosynthesis. (376 aa) |
| | acaB-4 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-4); Lipid metabolism. (397 aa) |
| | panB | Ketopantoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (267 aa) |
| | leuA-3 | 2-isopropylmalate synthase, putative (leuA-3); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. (347 aa) |
| | imp3 | Inositol monophosphosphatase, putative (imp3); Similar to MJ0109 with IMPase and fructose-1,6-bisphosphatase activities; Energy Metabolism, Sugar metabolism. (264 aa) |
| | cobA | Uroporphyrinogen III methylase (cobA); Cofactor Biosynthesis. (242 aa) |
| | ppcB | Propionyl-CoA carboxylase beta subunit (ppcB); Lipid metabolism. (523 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | sucD | Succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (260 aa) |
| | acaB-5 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-5); Lipid metabolism. (395 aa) |
| | fabG-7 | 3-oxoacyl-(acyl carrier protein) reductase (fabG-7); Lipid metabolism; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa) |
| | SSO2519 | Cyclase/dehydrase, putative; Cellular Processes. (308 aa) |
| | glpA | Glycerol-3-phosphate dehydrogenase chain A (glpA); Energy Metabolism. (445 aa) |
| | adh-10 | Alcohol dehydrogenase (Zn containing) (adh-10); Energy Metabolism; Belongs to the zinc-containing alcohol dehydrogenase family. (347 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (603 aa) |
| | glgP | Glucan phosphorylase, putative (glgP or malP); Most similar to maltodextrin and alpha glucan phosphorylases from T. litoralis and T. maritima; Energy Metabolism. (465 aa) |
| | pdhD-4 | Dihydrolipoamide dehydrogenase (pdhD-4); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (409 aa) |
| | sqdB-2 | L-lactate dehydrogenase (sqdB); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (327 aa) |
| | gltA | Citrate synthase; Energy Metabolism; Belongs to the citrate synthase family. (377 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa) |
| | paaF-7 | Enoyl CoA hydratase (paaF-7); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa) |
| | acaB-7 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-7); Lipid metabolism. (387 aa) |
| | glpC | Glycerol-3-phosphate dehydrogenase chain C (anaerobic) (glpC); Energy Metabolism. (395 aa) |
| | acaB-8 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-8); Lipid metabolism. (376 aa) |
| | SSO2747 | Conserved hypothetical protein. (262 aa) |
| | porB-2 | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-2); Energy Metabolism. (299 aa) |
| | porA-2 | Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-2); Energy Metabolism. (400 aa) |
| | porG-2 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa) |
| | SSO2815 | 2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa) |
| | SSO2816 | 2-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | acaB-9 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-9); Lipid metabolism. (395 aa) |
| | crtB | Phytoene synthetase (crtB); Cofactor Biosynthesis, Caretenoid Biosynthesis. (277 aa) |
| | crtZ | Beta carotene hydroxylase (crtZ); Cofactor Biosynthesis. (151 aa) |
| | crtI | Phytoene dehydrogenase (desaturase) (crtI); Cofactor Biosynthesis, Caretenoid Biosynthesis. (454 aa) |
| | cysG | Uroporphyrin-III C-methyltransferase (siroheme synthase) (cysG); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. (231 aa) |
| | sat | Sulfate adenylyltransferase (sat); Central Intermediary Metabolism, Sulfur. (406 aa) |
| | SSO2988 | (Phospho) mevalonate kinase, putative; Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. (323 aa) |
| | MvaD | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. (325 aa) |
| | dhg-1 | Glucose 1-dehydrogenase (dhg-1); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (366 aa) |
| | SSO3032 | Beta-xylosidase; Glycosyl hydrolase family 3; Central Intermediary Metabolism, Cytoplasmic polysaccharides. (754 aa) |
| | dapA-2 | Dihydrodipicolinate synthase (dapA-2); Amino Acid Biosynthesis, Aspartate. (302 aa) |
| | gusB | Beta-glucuronidase (gusB); Glycosyl hydrolase family 2; Central Intermediary Metabolism, Cytoplasmic polysaccharides. (570 aa) |
| | dhg-2 | Glucose 1-dehydrogenase (dhg-2); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (386 aa) |
| | malA | Alpha-glucosidase (malA); Major soluble alpha-glucosidase. (693 aa) |
| | dapA-3 | Dihydrodipicolinate synthase (dapA-3); Amino Acid Biosynthesis, Aspartate. (302 aa) |
| | ilvD | Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family. (558 aa) |
| | fabG-10 | 3-oxoacyl-(acyl carrier protein) reductase (fabG-10); Lipid metabolism. (252 aa) |
| | acd-7 | Acyl-CoA dehydrogenase (acd-7); Lipid metabolism. (389 aa) |
| | wrbA | Tryptophan repressor binding protein (wrbA); Transcription. (197 aa) |
| | glcD | Glycolate oxidase glcD subunit. (glcD); Energy Metabolism. (467 aa) |
| | dhg-3 | Glucose 1-dehydrogenase (dhg-3); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (360 aa) |
| | ilvB-6 | Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate. (543 aa) |
| | SSO3226 | Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa) |
| | hisE | Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis. (97 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase (hisI); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (85 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | porD-1 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa) |
