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| | hpS-1 | D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hpS-1); Energy Metabolism. (209 aa) |
| | hpS-2 | D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hpS-2); Similar to amino-end of most thermophilic homologues but same size as bacterial homologues. Carboxy-end seems to be upstream in distal SSO0151 orf; Energy Metabolism, Sugar metabolism. (225 aa) |
| | tdcB | Threonine dehydratase catabolic (threonine deaminase) (tdcB); Amino Acid Biosynthesis, Aspartate. (405 aa) |
| | fbp | Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (382 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | apgM | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. (433 aa) |
| | hdb-1 | 3-hydroxyacyl-CoA dehydrogenase (hdb-1); Lipid metabolism. (324 aa) |
| | paaF-2 | Enoyl CoA hydratase (paaF-2); Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (252 aa) |
| | SSO0666 | Glycerate kinase, putative; Uncategorized. (400 aa) |
| | adh-2 | Alcohol dehydrogenase (Zn containing) (adh-2); Energy Metabolism. (333 aa) |
| | ppsA-1 | Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa) |
| | serA-1 | D-3-phosphoglycerate dehydrogenase (serA-1); Amino Acid Biosynthesis, Histidine; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa) |
| | gcvPB | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (508 aa) |
| | gcvPA | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (455 aa) |
| | GcvT | Aminomethyltransferase; Energy Metabolism. (346 aa) |
| | gcvH1 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (137 aa) |
| | rpiA | Ribose 5-phosphate isomerase (rpiA); Energy Metabolism. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | fdhF-1 | Formate dehydrogenase Alpha subunit (fdhF-1); Energy Metabolism. (657 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | gcvH2 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (148 aa) |
| | fumC | Fumarate hydratase classe II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate. (445 aa) |
| | AcnA | Aconitate hydratase; Energy Metabolism, Tri-Carboxylic Acid Cycle. (855 aa) |
| | gcvH3 | Glycine cleavage system protein H, hypothetical; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (140 aa) |
| | porD-2 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2); Energy Metabolism. (94 aa) |
| | pdhD-1 | Dihydrolipoamide dehydrogenase (pdhD-1); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (446 aa) |
| | hdrC-1 | Heterodisulfide reductase, subunit C (hdrC-1); Energy Metabolism. (280 aa) |
| | hdrB-1 | Heterodisulfite reductase, subunit B (hdrB-1); Energy Metabolism. (437 aa) |
| | hdrA | Heterodisulfide reductase, subunit A (hdrA); Energy Metabolism. (368 aa) |
| | hdrC-2 | Heterodisulfide reductase subunit C (hdrC-2); Energy Metabolism. (230 aa) |
| | hdrB-2 | Heterodisulfide reductase, subunit B (hdrB-2); Energy Metabolism, Electron transport. (305 aa) |
| | SSO1154 | Monoamine oxidase regulatory protein; Uncategorized. (163 aa) |
| | porB-1 | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-1); Energy Metabolism. (300 aa) |
| | porG-1 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-1); Energy Metabolism. (190 aa) |
| | gdhA-1 | NAD specific glutamate dehydrogenase (gdhA-1); Amino Acid Biosynthesis, Glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (419 aa) |
| | pdhD-2 | Dihydrolipoamide dehydrogenase (pdhD-2); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (412 aa) |
| | pdhC | Dihydrolipoamide S-acetyltransferase, amino-end (pdhC); Probable frameshift with SSO1530; Energy Metabolism. (211 aa) |
| | pdhD-3 | Dihydrolipoamide dehydrogenase (pdhD-3); Highest hit with Thermoplasma; Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (456 aa) |
| | gdhA-2 | NAD specific glutamate dehydrogenase (gdhA-2); Amino Acid Biosynthesis, Glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (420 aa) |
| | gdhA-3 | NAD specific glutamate dehydrogenase (gdhA-3); Amino Acid Biosynthesis, Glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (434 aa) |
| | acsA-5 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism. (498 aa) |
| | acaB-2 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-2); Lipid metabolism. (381 aa) |
| | acaB-3 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-3); Lipid metabolism. (409 aa) |
| | acsA-7 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-7); Lipid metabolism. (608 aa) |
| | porD-like | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-like); Contains long amino-end extension, only present in M. thermoautrophicum MTH1740 gene; Energy Metabolism. (363 aa) |
| | porA-like | Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-like); Energy Metabolism. (415 aa) |
| | porB-like | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-like); Energy Metabolism. (338 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (asd-2); Amino Acid Biosynthesis, Aspartate. (356 aa) |
| | idh | Isocitrate dehydrogenase, probable (idh); Energy Metabolism, Tri-Carboxylic Acid Cycle. (413 aa) |
| | acsA-8 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-8); Lipid metabolism. (571 aa) |
| | SSO2236 | Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa) |
| | ppcA | Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (511 aa) |
| | mcmA2 | Methylmalonyl-CoA mutase, alpha-subunit, chain B (mcmA2); Cellular Processes, Detoxification. (141 aa) |
| | SSO2281 | Conserved hypothetical protein; Involved in the synthesis of UDP-N-acetylgalactosamine (UDP- GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P). Belongs to the PGI/PMI family. (296 aa) |
| | sdhA | Succinate dehydrogenase subunit A (sdhA); Flavoprotein subunit; Energy Metabolism, Electron transport. (566 aa) |
| | sdhB | Succinate dehydrogenase subunit B (sdhB); Iron-sulfur subunit B; Energy Metabolism, Electron transport. (316 aa) |
| | sdhC | Succinate dehydrogenase subunit C (sdhC); Iron-sulfur subunit C; also hit with htrB2 subunit of heterodisulfide reductase; Energy Metabolism, Electron transport. (293 aa) |
| | sdhD | Succinate dehydrogenase subunit D (sdhD); Subunit D; Energy Metabolism, Electron transport. (121 aa) |
| | acaB-4 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-4); Lipid metabolism. (397 aa) |
| | mcmA1 | Methylmalonyl-CoA mutase, alpha-subunit, chain A (mcmA1); Highly conserved with Pyrococcus and Archaeoglobus; Cellular Processes, Detoxification. (561 aa) |
| | Mce | Lactoylglutathione lyase (glyoxalase I), putative; Energy Metabolism. (142 aa) |
| | ppcB | Propionyl-CoA carboxylase beta subunit (ppcB); Lipid metabolism. (523 aa) |
| | sucD | Succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (260 aa) |
| | SSO2514 | Contains 3-Hydroxyacyl-CoA dehydrogenase domain at amino terminus and Enoyl CoA hydratase domain at carboxy terminus; Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family. (663 aa) |
| | pdhD-4 | Dihydrolipoamide dehydrogenase (pdhD-4); Energy Metabolism, Dehydrogenases; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (409 aa) |
| | sqdB-2 | L-lactate dehydrogenase (sqdB); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (327 aa) |
| | gltA | Citrate synthase; Energy Metabolism; Belongs to the citrate synthase family. (377 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa) |
| | acaB-7 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-7); Lipid metabolism. (387 aa) |
| | cutB-2 | Carbon monoxide dehydrogenase, medium chain. (cutB-2); Energy Metabolism. (282 aa) |
| | cutC-2-2 | Carbon monoxide dehydrogenase, small chain. Amino-end fragment (cutC-2); Probable frameshift with SSO10802; Energy Metabolism. (163 aa) |
| | cutA-4 | Carbon monoxide dehydrogenase, large chain (cutA-4); Energy Metabolism. (749 aa) |
| | fabG-8 | 3-oxoacyl-(acyl carrier protein) reductase (fabG-8); Lipid metabolism. (252 aa) |
| | abfD-2 | 4-hydroxybutyryl-CoA dehydratase (abfD-2); Amino Acid Biosynthesis. (502 aa) |
| | porB-2 | Pyruvate synthase beta chain (Pyruvic-ferredoxin oxidoreductase beta chain) (porB-2); Energy Metabolism. (299 aa) |
| | porA-2 | Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (porA-2); Energy Metabolism. (400 aa) |
| | porG-2 | Pyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2); Energy Metabolism. (184 aa) |
| | SSO2815 | 2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism. (632 aa) |
| | SSO2816 | 2-oxoacid--ferredoxin oxidoreductase, beta chain; Energy Metabolism. (316 aa) |
| | fdhF-2 | Formate dehydrogenase Alpha subunit (fdhF-2); Energy Metabolism. (979 aa) |
| | acsA-9 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-9); Lipid metabolism. (666 aa) |
| | SSO2869 | NAD-dependent malic enzyme (malate oxidoreductase); Energy Metabolism. (432 aa) |
| | hdb-2 | 3-hydroxyacyl-CoA dehydrogenase (hdb-2); Lipid metabolism. (370 aa) |
| | acaB-9 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-9); Lipid metabolism. (395 aa) |
| | hdb-3 | 3-hydroxyacyl-CoA dehydrogenase (hdb-3); Lipid metabolism. (384 aa) |
| | SSO2998 | Conserved hypothetical protein; Probably belongs to mandelate racemase / muconate lactonizing enzyme family. (419 aa) |
| | dhg-1 | Glucose 1-dehydrogenase (dhg-1); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (366 aa) |
| | dhg-2 | Glucose 1-dehydrogenase (dhg-2); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (386 aa) |
| | gapN-3 | Glyceraldehyde-3-phosphate dehydrogenase, NADP dependent (gapN-3); Catalyzes the irreversible NAD(P)-dependent non- phosphorylating oxidation of glyceraldehyde-3-phosphate (GAP) to 3- phosphoglycerate (3PG). It is highly specific for D-GAP. (509 aa) |
| | kdgK | Fructokinase; Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal), respectively. (313 aa) |
| | eda | 2-keto-3-deoxy gluconate aldolase (eda); Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto- 3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2- keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3- deoxygalactonate (KDGal). (308 aa) |
| | gad | Muconate cycloisomerase related protein; Involved in the degradation of glucose and galactose via the branched variant of the Entner-Doudoroff pathway. Catalyzes the dehydration of gluconate to produce 2-keto-3-deoxygluconate (KDG). It is also able to catalyze the dehydration of galactonate to produce 2- keto-3-deoxygalactonate (KDGal); Belongs to the mandelate racemase/muconate lactonizing enzyme family. GaD subfamily. (395 aa) |
| | acsA-10 | Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-10); Lipid metabolism. (652 aa) |
| | dhg-3 | Glucose 1-dehydrogenase (dhg-3); Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. (360 aa) |
| | SSO3226 | Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa) |
| | porD-1 | Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-1); Energy Metabolism. (88 aa) |
