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| | leuA-1 | 2-isopropylmalate synthase, putative (leuA-1); Amino Acid Biosynthesis, Pyruvate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (553 aa) |
| | hpS-1 | D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hpS-1); Energy Metabolism. (209 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase (argC); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (352 aa) |
| | argB | Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | rimK-1 | Ribosomal protein S6 modification protein (rimK-1); Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma- carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily. (286 aa) |
| | argD | Acetylornithine aminotransferase (argD); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (392 aa) |
| | lysK | Conserved hypothetical protein; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (346 aa) |
| | maT | S-adenosylmethionine synthetase (maT); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (410 aa) |
| | hpS-2 | D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hpS-2); Similar to amino-end of most thermophilic homologues but same size as bacterial homologues. Carboxy-end seems to be upstream in distal SSO0151 orf; Energy Metabolism, Sugar metabolism. (225 aa) |
| | pheA | Probable chorismate mutase (CM)/prephenate dehydratase (PDT) (pheA); Amino Acid Biosynthesis. (269 aa) |
| | tdcB | Threonine dehydratase catabolic (threonine deaminase) (tdcB); Amino Acid Biosynthesis, Aspartate. (405 aa) |
| | fbp | Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (382 aa) |
| | tkt-1 | Transketolase, N-terminal section (tkt-1); Energy Metabolism, Sugar metabolism. (281 aa) |
| | tkt-2 | Transketolase, C-terminal section (tkt-2); Energy Metabolism, Sugar metabolism. (313 aa) |
| | tyrA | Chorismate mutase/prephenate dehydratase, putative (tyrA); Amino Acid Biosynthesis. (346 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Amino Acid Biosynthesis, Aromatic amino acids. (331 aa) |
| | aroB | 3-dehydroquinate synthase (aroB); Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (354 aa) |
| | aroE | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroC | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | aroK | Conserved hypothetical protein; Similarity with AF0250, MJ1440, PAB0301, MTH805. Distantly related to homoserine/aspartokinases. (275 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | aroD | 3-dehydroquinate dehydratase, putative (aroD); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (220 aa) |
| | glnA-1 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-1); Amino Acid Biosynthesis, Glutamate. (471 aa) |
| | metE-1 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-1); Amino Acid Biosynthesis. (330 aa) |
| | metE-2 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-2); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (332 aa) |
| | apgM | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa) |
| | hisC-like | Histidinol-phosphate aminotransferase, putative (hisC-like); Amino Acid Biosynthesis, Histidine. (326 aa) |
| | pgk | Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. (433 aa) |
| | ilvC-1 | Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa) |
| | ilvB-2 | Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate. (572 aa) |
| | hisC | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. (376 aa) |
| | hisG | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. (232 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (251 aa) |
| | hisD | Histidinol dehydrogenase (HDH) (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (398 aa) |
| | hisH | Amidotransferase hisH (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (199 aa) |
| | argG | Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argH | Argininosuccinate lyase (argH); Amino Acid Biosynthesis, Glutamate. (459 aa) |
| | rimK-2 | Translation, Protein modification. (282 aa) |
| | thrA/hom | Homoserine dehydrogenase (thrA/hom); Amino Acid Biosynthesis, Aspartate. (314 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (leuB); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (336 aa) |
| | argF | Ornithine carbamoyltransferase (argF); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | asd-1 | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (asd-1); Amino Acid Biosynthesis, Aspartate. (350 aa) |
| | akH | Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family. (446 aa) |
| | thrC-2 | Threonine synthase (thrC-2); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (396 aa) |
| | trpB | Tryptophan synthase beta chain (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (425 aa) |
| | trpA | Tryptophan synthase alpha chain (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (245 aa) |
| | trpD | Anthranilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpF | Phosphoribosyl anthranilate isomerase (trpF); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the TrpF family. (204 aa) |
| | trpE | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (421 aa) |
| | trpGD | Anthranilate synthase component II (trpGD); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (195 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (trpC); Amino Acid Biosynthesis, Aromatic amino acids. (248 aa) |
| | aspB-2 | Aspartate aminotransferase (aspB-2); Amino Acid Biosynthesis, Aspartate. (402 aa) |
| | serA-1 | D-3-phosphoglycerate dehydrogenase (serA-1); Amino Acid Biosynthesis, Histidine; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (419 aa) |
| | leuA-2 | 2-isopropylmalate synthase (leuA-2); Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. (461 aa) |
| | rpiA | Ribose 5-phosphate isomerase (rpiA); Energy Metabolism. (227 aa) |
| | pyK | Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family. (452 aa) |
| | argE-2 | Acetylornithine deacetylase (argE-2); Amino Acid Biosynthesis. (376 aa) |
| | prs | Ribose phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (294 aa) |
| | AcnA | Aconitate hydratase; Energy Metabolism, Tri-Carboxylic Acid Cycle. (855 aa) |
| | trpB-like | Tryptophan synthase beta chain, hypothetical (trpB-like); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (429 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase (dapE); Amino Acid Biosynthesis. (410 aa) |
| | ilvC-3 | Ketol-acid reductoisomerase (ilvC-3); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family. (332 aa) |
| | idh | Isocitrate dehydrogenase, probable (idh); Energy Metabolism, Tri-Carboxylic Acid Cycle. (413 aa) |
| | SSO2236 | Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism. (216 aa) |
| | dapA-1 | Dihydrodipicolinate synthase (dapA-1); Amino Acid Biosynthesis, Aspartate. (289 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa) |
| | metB | O-succinylhomoserine (thiol)-lyase (cystathionine gamma-synthase) (metB); Amino Acid Biosynthesis. (376 aa) |
| | leuA-3 | 2-isopropylmalate synthase, putative (leuA-3); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. (347 aa) |
| | glnA-2 | Glutamine synthetase (glutamate ammonia ligase) (GS). (glnA-2); Amino Acid Biosynthesis, Glutamate; Belongs to the glutamine synthetase family. (425 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | gltA | Citrate synthase; Energy Metabolism; Belongs to the citrate synthase family. (377 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (227 aa) |
| | dapA-2 | Dihydrodipicolinate synthase (dapA-2); Amino Acid Biosynthesis, Aspartate. (302 aa) |
| | dapA-3 | Dihydrodipicolinate synthase (dapA-3); Amino Acid Biosynthesis, Aspartate. (302 aa) |
| | ilvD | Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family. (558 aa) |
| | ilvB-6 | Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate. (543 aa) |
| | SSO3226 | Conserved hypothetical protein; Belongs to the DeoC/FbaB aldolase family. (272 aa) |
| | hisE | Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis. (97 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase (hisI); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (85 aa) |
