10 items (Saccharolobus solfataricus) - STRING interaction network

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	ntH-1	DNA endonuclease III, probable (ntH-1); Replication and Repair. (236 aa)
	rad2	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...] (302 aa)
	lig	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (601 aa)
	pcnA-like	Proliferating cell nuclear antigen putative homolog (PCNA-like) (pcnA-like); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (249 aa)
	pcnA-1	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc. (259 aa)
	pcnA-2	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-2); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. (246 aa)
	SSO2156	Endonuclease IV related protein; Replication and Repair. (283 aa)
	udg1	DNA polymerase phage SPO1 N-terminal domain homolog; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. (216 aa)
	Xth	Exodeoxyribonuclease; Replication and Repair. (247 aa)
	SSO2733	Conserved hypothetical protein; Possibly an uracil-DNA glycosylase (COG1573). (219 aa)

Your Current Organism:

Saccharolobus solfataricus

NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SSO2156	Xth	SSO2156	SSO2290	Endonuclease IV related protein; Replication and Repair.	Exodeoxyribonuclease; Replication and Repair.	0.881
SSO2156	lig	SSO2156	SSO0189	Endonuclease IV related protein; Replication and Repair.	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.417
SSO2156	ntH-1	SSO2156	SSO0116	Endonuclease IV related protein; Replication and Repair.	DNA endonuclease III, probable (ntH-1); Replication and Repair.	0.922
SSO2156	pcnA-1	SSO2156	SSO0405	Endonuclease IV related protein; Replication and Repair.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.448
SSO2156	rad2	SSO2156	SSO0179	Endonuclease IV related protein; Replication and Repair.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.661
SSO2733	udg1	SSO2733	SSO2275	Conserved hypothetical protein; Possibly an uracil-DNA glycosylase (COG1573).	DNA polymerase phage SPO1 N-terminal domain homolog; Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.	0.907
Xth	SSO2156	SSO2290	SSO2156	Exodeoxyribonuclease; Replication and Repair.	Endonuclease IV related protein; Replication and Repair.	0.881
Xth	lig	SSO2290	SSO0189	Exodeoxyribonuclease; Replication and Repair.	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.970
Xth	ntH-1	SSO2290	SSO0116	Exodeoxyribonuclease; Replication and Repair.	DNA endonuclease III, probable (ntH-1); Replication and Repair.	0.969
Xth	pcnA-1	SSO2290	SSO0405	Exodeoxyribonuclease; Replication and Repair.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.831
Xth	pcnA-2	SSO2290	SSO1047	Exodeoxyribonuclease; Replication and Repair.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-2); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.831
Xth	pcnA-like	SSO2290	SSO0397	Exodeoxyribonuclease; Replication and Repair.	Proliferating cell nuclear antigen putative homolog (PCNA-like) (pcnA-like); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.831
Xth	rad2	SSO2290	SSO0179	Exodeoxyribonuclease; Replication and Repair.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.984
lig	SSO2156	SSO0189	SSO2156	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	Endonuclease IV related protein; Replication and Repair.	0.417
lig	Xth	SSO0189	SSO2290	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	Exodeoxyribonuclease; Replication and Repair.	0.970
lig	ntH-1	SSO0189	SSO0116	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	DNA endonuclease III, probable (ntH-1); Replication and Repair.	0.577
lig	pcnA-1	SSO0189	SSO0405	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-1); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.	0.997
lig	pcnA-2	SSO0189	SSO1047	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	Proliferating cell nuclear antigen homolog (PCNA) (pcnA-2); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.996
lig	pcnA-like	SSO0189	SSO0397	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	Proliferating cell nuclear antigen putative homolog (PCNA-like) (pcnA-like); One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	0.986
lig	rad2	SSO0189	SSO0179	DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.	DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]	0.986