STRINGSTRING
carB carB thyX thyX ST1632 ST1632 tmk-2 tmk-2 ST1542 ST1542 carA carA pyrF pyrF dut dut pyrG pyrG ndk ndk upp upp tmk tmk ST1011 ST1011 ST1020 ST1020 pydB pydB pydA pydA pyrH pyrH pyrD pyrD pyrC pyrC pyrK pyrK pyrI pyrI pyrB pyrB pyrE pyrE
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
carBCarbamoyl-phosphate synthase large chain. (1049 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (257 aa)
ST1632Putative dUTP diphosphatase; N-term changed (-24); protein synonym:dUTPase. (159 aa)
tmk-2Probable thymidylate kinase; Protein synonym:dTMP kinase. (213 aa)
ST1542Hypothetical protein; N-term changed (+111). (205 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (372 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa)
dutdUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. (183 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (147 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
tmkProbable thymidylate kinase; Protein synonym:dTMP kinase. (190 aa)
ST1011Putative dihydropyrimidinase; Protein synonym:hydantoinase. (433 aa)
ST1020Putative dihydropyrimidinase; Protein synonym:hydantoinase. (413 aa)
pydBDihydropyrimidinase; Protein synonym:hydantoinase. (464 aa)
pydADihydropyrimidine dehydrogenase. (350 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (226 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (288 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (389 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; N-term changed (+351). (195 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (160 aa)
pyrBAspartate carbamoyltransferase. (298 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa)
Your Current Organism:
Sulfurisphaera tokodaii
NCBI taxonomy Id: 273063
Other names: S. tokodaii str. 7, Sulfolobus sp. (strain 7), Sulfolobus sp. 7, Sulfolobus tokodaii str. 7, Sulfurisphaera tokodaii str. 7, Sulfurisphaera tokodaii strain 7
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