STRINGSTRING
dut dut pyrG pyrG ndk ndk upp upp cmk cmk tmk tmk ST1011 ST1011 ST1014 ST1014 pydC pydC ST1020 ST1020 pydB pydB pydA pydA pydC-2 pydC-2 nrd nrd pyrH pyrH pyrD pyrD pyrC pyrC pyrI pyrI pyrB pyrB pyrE pyrE pyrF pyrF carA carA carB carB ST1542 ST1542 tmk-2 tmk-2 ST1620 ST1620 ST1632 ST1632 thyX thyX codA codA ST2449 ST2449
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
dutdUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. (183 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (147 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
cmkPutative cytidylate kinase. (180 aa)
tmkProbable thymidylate kinase; Protein synonym:dTMP kinase. (190 aa)
ST1011Putative dihydropyrimidinase; Protein synonym:hydantoinase. (433 aa)
ST1014Putative cytosine deaminase. (355 aa)
pydCBeta-alanine synthase; Protein synonym:beta-ureidopropionase. (264 aa)
ST1020Putative dihydropyrimidinase; Protein synonym:hydantoinase. (413 aa)
pydBDihydropyrimidinase; Protein synonym:hydantoinase. (464 aa)
pydADihydropyrimidine dehydrogenase. (350 aa)
pydC-2Beta-alanine synthase; N-term changed (-9); N-terminus of this ORF was identified by Edman sequencing; protein synonym:beta-ureidopropionase. (278 aa)
nrdRibonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (831 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (226 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (288 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (389 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (160 aa)
pyrBAspartate carbamoyltransferase. (298 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (372 aa)
carBCarbamoyl-phosphate synthase large chain. (1049 aa)
ST1542Hypothetical protein; N-term changed (+111). (205 aa)
tmk-2Probable thymidylate kinase; Protein synonym:dTMP kinase. (213 aa)
ST1620Hypothetical protein. (212 aa)
ST1632Putative dUTP diphosphatase; N-term changed (-24); protein synonym:dUTPase. (159 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (257 aa)
codACytosine deaminase. (412 aa)
ST2449Hypothetical protein. (266 aa)
Your Current Organism:
Sulfurisphaera tokodaii
NCBI taxonomy Id: 273063
Other names: S. tokodaii str. 7, Sulfolobus sp. (strain 7), Sulfolobus sp. 7, Sulfolobus tokodaii str. 7, Sulfurisphaera tokodaii str. 7, Sulfurisphaera tokodaii strain 7
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