STRINGSTRING
PykF PykF BmrU BmrU BaeS12 BaeS12 ThrB ThrB TTE2616 TTE2616 FruK FruK PtsN3 PtsN3 FruA FruA BaeS11 BaeS11 IspE IspE BaeS10 BaeS10 BaeS9 BaeS9 coaX coaX LytS2 LytS2 mcsB mcsB ThiM ThiM KdpD2 KdpD2 KdpD KdpD GlpK GlpK Dak1.2 Dak1.2 Dak1 Dak1 TTE1995 TTE1995 HprK HprK NagC4 NagC4 XylB XylB GalK GalK TTE1833 TTE1833 PfkA PfkA BaeS8 BaeS8 BaeS7 BaeS7 Sps1 Sps1 TTE1493 TTE1493 CheA2 CheA2 RibF RibF RsbW3 RsbW3 nadK nadK AroK AroK AarF AarF CheA CheA NagC NagC TTE0182 TTE0182 TTE0193 TTE0193 RbsK RbsK anmK anmK LytS LytS PtsN4 PtsN4 SgaB SgaB CelB CelB CelA CelA MtlA MtlA TTE0340 TTE0340 CobU CobU PtsG PtsG BaeS BaeS BaeS2 BaeS2 TTE0598 TTE0598 CelA2 CelA2 CelB2 CelB2 Mrp2 Mrp2 RfaE RfaE BaeS3 BaeS3 TTE0871 TTE0871 CoaE CoaE TTE0916 TTE0916 TTE0980 TTE0980 BaeS5 BaeS5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PykFPyruvate kinase; Best Blastp hit = gi|10175785|dbj|BAB06882.1| (AP001517) pyruvate kinase [Bacillus halodurans], score 674, E-value 0; Belongs to the pyruvate kinase family. (583 aa)
BmrUConserved hypothetical protein; Best Blastp hit = gi|10174571|dbj|BAB05672.1| (AP001513) BH1953; unknown conserved protein [Bacillus halodurans], score 141, E-value 1.00E-32. (291 aa)
BaeS12Sensory transduction histidine kinases; Best Blastp hit = gi|7475968|pir||F70089 two-component sensor histidine kinase homolog yycG - Bacillus subtilis gi|1064813|dbj|BAA11299.1| (D78193) homologous to sp:PHOR_BACSU [Bacillus subtilis] gi|2636587|emb|CAB16077.1| (Z99124) similar to two-component sensor histidine kinase [YycF] [Bacillus subtilis], score 363, E-value 3.00E-99. (577 aa)
ThrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
TTE2616Glycerate kinase; Best Blastp hit = gi|12723784|gb|AAK04954.1|AE006320_3 (AE006320) conserved hypothetical protein [Lactococcus lactis subsp. lactis], score 343, E-value 3.00E-93; Belongs to the glycerate kinase type-1 family. (377 aa)
FruKFructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Best Blastp hit = gi|11259262|pir||C82450 1-phosphofructokinase VCA0517 [imported] - Vibrio cholerae (group O1 strain N16961) gi|9657922|gb|AAF96420.1| (AE004382) 1-phosphofructokinase [Vibrio cholerae], score 169, E-value 3.00E-41; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (316 aa)
PtsN3Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Best Blastp hit = gi|13622026|gb|AAK33783.1| '(AE006535) putative fructose-specific enzyme II, PTS system BC component [Streptococcus pyogenes]', score 117, E-value 6.00E-26. (151 aa)
FruABest Blastp hit = gi|131491|sp|P23387|PTFB_RHOCA 'PTS SYSTEM, FRUCTOSE-SPECIFIC IIBC COMPONENT (EIIBC-FRU) (FRUCTOSE-PERMEASE IIBC COMPONENT) (PHOSPHOTRANSFERASE ENZYME II, BC COMPONENT) (EII-FRU)' gi|97494|pir||B37852 'phosphotransferase system enzyme II (EC 2.7.1.69), fructose-specific - Rhodobacter capsulatus' gi|46021|emb|CAA37303.1| (X53150) fructose enzyme II [Rhodobacter capsulatus], score 537, E-value 1.00E-152. (452 aa)
BaeS11Sensory transduction histidine kinases; Best Blastp hit = gi|10174563|dbj|BAB05664.1| (AP001513) two-component sensor histidine kinase [Bacillus halodurans], score 221, E-value 2.00E-56. (469 aa)
IspE4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa)
BaeS10Sensory transduction histidine kinases; Best Blastp hit = gi|10174563|dbj|BAB05664.1| (AP001513) two-component sensor histidine kinase [Bacillus halodurans], score 181, E-value 2.00E-44. (451 aa)
BaeS9Sensory transduction histidine kinases; Best Blastp hit = gi|732226|sp|Q06067|ATOS_ECOLI SENSOR PROTEIN ATOS gi|7466912|pir||A64992 sensor protein AtoS (EC 2.7.3.-) - Escherichia coli (strain K-12) gi|290419|gb|AAA23449.1| (L13078) ORF-1 [Escherichia coli] gi|1736874|dbj|BAA16015.1| (D90851) Sensor protein AtoS (EC 2.7.3.-). [Escherichia coli] gi|1788549|gb|AAC75279.1| (AE000311) sensor protein AtoS for response regulator AtoC [Escherichia coli K12], score 129, E-value 1.00E-28. (462 aa)
coaXPutative transcriptional regulator, homologs of Bvg accessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (255 aa)
LytS2Predicted ATPase; Best Blastp hit = gi|10176070|dbj|BAB07166.1| (AP001518) two-component sensor histidine kinase [Bacillus halodurans], score 236, E-value 6.00E-61. (593 aa)
mcsBCreatine kinase; Catalyzes the specific phosphorylation of arginine residues in proteins. (337 aa)
ThiMHydroxyethylthiazole kinase, sugar kinase family; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa)
KdpD2Osmosensitive K+ channel His kinase sensor domain protein; Best Blastp hit = gi|13472735|ref|NP_104302.1| two-component sensor KdpD [Mesorhizobium loti] gi|14023482|dbj|BAB50088.1| (AP003001) two-component sensor; KdpD [Mesorhizobium loti], score 366, E-value 1.00E-100. (380 aa)
KdpDOsmosensitive K+ channel His kinase sensor domain protein; Best Blastp hit = gi|11281914|pir||T46849 K+-transporting ATPase (EC 3.6.1.-) chain D' [imported] - Anabaena sp gi|6635817|gb|AAF19990.1|AF213466_5 (AF213466) potassium-dependent ATPase subunit D' [Anabaena sp. L-31], score 312, E-value 4.00E-84. (365 aa)
GlpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (497 aa)
Dak1.2Dihydroxyacetone kinase; Best Blastp hit = gi|10176020|dbj|BAB07116.1| (AP001518) dihydroxyacetone kinase [Bacillus halodurans], score 320, E-value 1.00E-86. (332 aa)
Dak1Dihydroxyacetone kinase; Best Blastp hit = gi|10186493|gb|AAG14892.1|AF297121_5 (AF297121) unknown [Selenomonas ruminantium subsp. ruminantium], score 196, E-value 2.00E-49. (212 aa)
TTE1995Conserved hypothetical protein; Best Blastp hit = gi|2506647|sp|P37349|YCGC_ECOLI HYPOTHETICAL 51.6 KDA PROTEIN IN TREA-PTH INTERGENIC REGION gi|7466956|pir||C64866 trehalase precursor - Escherichia coli gi|1787448|gb|AAC74282.1| (AE000218) putative PTS system enzyme I [Escherichia coli K12] gi|4062781|dbj|BAA36055.1| (D90754) Hypothetical protein in treA 5'region. [Escherichia coli], score 80.5, E-value 8.00E-15. (135 aa)
HprKSerine kinase of the HPr protein, regulates carbohydrate metabolism; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence [...] (305 aa)
NagC4Transcriptional regulator; Best Blastp hit = gi|7442875|pir||F72246 glucokinase - Thermotoga maritima (strain MSB8) gi|4982035|gb|AAD36537.1|AE001798_2 (AE001798) glucokinase [Thermotoga maritima], score 223, E-value 3.00E-57. (312 aa)
XylBSugar (pentulose and hexulose) kinases; Best Blastp hit = gi|12725247|gb|AAK06282.1|AE006447_3 (AE006447) gluconate kinase (EC 2.7.1.12) [Lactococcus lactis subsp. lactis], score 250, E-value 3.00E-65; Belongs to the FGGY kinase family. (494 aa)
GalKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa)
TTE1833Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (318 aa)
PfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa)
BaeS8Sensory transduction histidine kinases; Best Blastp hit = gi|10176253|dbj|BAB07348.1| (AP001519) two-component sensor histidine kinase involved in degradative enzyme [Bacillus halodurans], score 256, E-value 3.00E-67. (388 aa)
BaeS7Sensory transduction histidine kinases; Best Blastp hit = gi|10175778|dbj|BAB06875.1| (AP001517) two-component sensor histidine kinase involved in phosphate regulation [Bacillus halodurans], score 262, E-value 6.00E-69. (456 aa)
Sps1Serine/threonine protein kinase; Best Blastp hit = gi|10175124|dbj|BAB06223.1| (AP001515) serine/threonine protein kinase [Bacillus halodurans], score 319, E-value 7.00E-86; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (625 aa)
TTE1493Predicted kinase related to dihydroxyacetone kinase; Best Blastp hit = gi|7429544|pir||E69879 conserved hypothetical protein yloV - Bacillus subtilis gi|2337813|emb|CAA74257.1| (Y13937) YloV protein [Bacillus subtilis] gi|2633956|emb|CAB13457.1| (Z99112) similar to hypothetical proteins [Bacillus subtilis], score 438, E-value 1.00E-122. (525 aa)
CheA2Chemotaxis protein histidine kinase and related kinases; Best Blastp hit = gi|10175592|dbj|BAB06689.1| (AP001517) two-component sensor histidine kinase involved in chemotaxis [Bacillus halodurans], score 542, E-value 1.00E-153. (646 aa)
RibFFAD synthase; Best Blastp hit = gi|7444639|pir||D70313 riboflavin kinase - Aquifex aeolicus gi|2982868|gb|AAC06488.1| (AE000675) riboflavin kinase [Aquifex aeolicus], score 193, E-value 3.00E-48; Belongs to the ribF family. (316 aa)
RsbW3Anti-sigma regulatory factor (Ser/Thr protein kinase); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (143 aa)
nadKPredicted kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (283 aa)
AroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
AarFPredicted unusual protein kinase; Best Blastp hit = gi|10175329|dbj|BAB06427.1| (AP001516) ABC transporter [Bacillus halodurans], score 318, E-value 1.00E-85. (555 aa)
CheAChemotaxis protein histidine kinase and related kinases; Best Blastp hit = gi|11354461|pir||E82205 chemotaxis protein CheA VC1397 [imported] - Vibrio cholerae (group O1 strain N16961) gi|9655892|gb|AAF94554.1| (AE004218) chemotaxis protein CheA [Vibrio cholerae], score 326, E-value 8.00E-88. (803 aa)
NagCTranscriptional regulator; Best Blastp hit = gi|13476027|ref|NP_107597.1| glucose kinase [Mesorhizobium loti] gi|14026787|dbj|BAB53383.1| (AP003011) glucose kinase [Mesorhizobium loti], score 250, E-value 2.00E-65. (315 aa)
TTE0182Best Blastp hit = gi|10172803|dbj|BAB03910.1| '(AP001507) PTS system, galactitol-specific enzyme II, B component [Bacillus halodurans]', score 91.3, E-value 2.00E-18. (97 aa)
TTE0193Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Best Blastp hit = gi|1142714|gb|AAB04152.1| (U28163) phosphoenolpyruvate:mannose phosphotransferase element IIB [Lactobacillus curvatus], score 105, E-value 3.00E-22. (167 aa)
RbsKSugar kinases, ribokinase family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (396 aa)
LytSPredicted ATPase; Best Blastp hit = gi|10176466|dbj|BAB07560.1| (AP001520) two-component sensor histidine kinase [Bacillus halodurans], score 264, E-value 2.00E-69. (493 aa)
PtsN4Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Best Blastp hit = gi|10172832|dbj|BAB03939.1| (AP001507) BH0220; unknown conserved protein [Bacillus halodurans], score 308, E-value 1.00E-82. (693 aa)
SgaBPhosphotransferase system component IIB of unknown specificity; Best Blastp hit = gi|13469797|gb|AAK27336.1| (AF286670) unknown [Escherichia coli], score 66.2, E-value 1.00E-10. (103 aa)
CelBPhosphotransferase system cellobiose-specific component IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (429 aa)
CelABest Blastp hit = gi|11497017|ref|NP_046992.1| 'PTS system, cellobiose-specific IIB component (celA) [Borrelia burgdorferi]' gi|7450521|pir||B70217 'PTS system, cellobiose-specific IIB component (celA) homolog - Lyme disease spirochete plasmid B/cp26' gi|2689898|gb|AAC66322.1| '(AE000792) PTS system, cellobiose-specific IIB component (celA) [Borrelia burgdorferi]' gi|4101692|gb|AAD01257.1| (AF006036) unknown [Borrelia burgdorferi], score 86.7, E-value 8.00E-17. (103 aa)
MtlAPhosphotransferase system, mannitol-specific IIBC component; Best Blastp hit = gi|3025454|gb|AAC12848.1| (U53868) MtlA [Clostridium acetobutylicum], score 544, E-value 1.00E-154. (477 aa)
TTE0340Putative transcriptional regulator; Best Blastp hit = gi|3025455|gb|AAC12849.1| (U53868) MtlR [Clostridium acetobutylicum], score 481, E-value 1.00E-134. (673 aa)
CobUBest Blastp hit = gi|7471254|pir||G75594 cobinamide kinase/cobinamide phosphate guanylyltransferase - Deinococcus radiodurans (strain R1) gi|6460576|gb|AAF12282.1|AE001862_108 (AE001862) cobinamide kinase/cobinamide phosphate guanylyltransferase [Deinococcus radiodurans], score 147, E-value 1.00E-34. (182 aa)
PtsGPhosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Best Blastp hit = gi|10173035|dbj|BAB04141.1| '(AP001508) PTS system, N-acetylglucosamine-specific enzyme II, ABC component [Bacillus halodurans]', score 418, E-value 1.00E-116. (449 aa)
BaeSSensory transduction histidine kinases; Best Blastp hit = gi|10174563|dbj|BAB05664.1| (AP001513) two-component sensor histidine kinase [Bacillus halodurans], score 186, E-value 4.00E-46. (468 aa)
BaeS2Sensory transduction histidine kinases; Best Blastp hit = gi|13701832|dbj|BAB43125.1| (AP003135) accessory gene regulator C [Staphylococcus aureus] gi|13873740|dbj|BAB44964.1| (AP003364) accessory gene regulator protein C [Staphylococcus aureus], score 74.7, E-value 1.00E-12. (289 aa)
TTE0598Putative transcriptional regulator; Best Blastp hit = gi|1480429|gb|AAC44464.1| (U18943) putative transcriptional regulator [Bacillus stearothermophilus], score 297, E-value 3.00E-79. (694 aa)
CelA2Best Blastp hit = gi|11280254|pir||D82219 'PTS system, cellobiose-specific IIB component VC1281 [imported] - Vibrio cholerae (group O1 strain N16961)' gi|9655767|gb|AAF94440.1| '(AE004207) PTS system, cellobiose-specific IIB component [Vibrio cholerae]', score 70.9, E-value 4.00E-12. (108 aa)
CelB2Phosphotransferase system cellobiose-specific component IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (436 aa)
Mrp2ATPases involved in chromosome partitioning; Best Blastp hit = gi|7450015|pir||G70066 capsular polysaccharide biosynthesis homolog ywqD - Bacillus subtilis gi|1894742|emb|CAB07457.1| (Z92952) product similar to Staphilococcus aureus CapB protein [Bacillus subtilis] gi|2636150|emb|CAB15642.1| (Z99122) similar to capsular polysaccharide biosynthesis [Bacillus subtilis], score 189, E-value 4.00E-47. (236 aa)
RfaEADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase; Best Blastp hit = gi|7514234|pir||H70350 ADP-heptose synthase - Aquifex aeolicus gi|2983198|gb|AAC06797.1| (AE000696) ADP-heptose synthase [Aquifex aeolicus], score 89.4, E-value 7.00E-17. (349 aa)
BaeS3Sensory transduction histidine kinases; Best Blastp hit = gi|3687664|gb|AAC62214.1| (AF049873) sensor protein [Lactococcus lactis], score 148, E-value 2.00E-34. (448 aa)
TTE0871Regulator of cell autolysis; Best Blastp hit = gi|7429363|pir||A69655 two-component sensor histidine kinase lytS-involved - Bacillus subtilis gi|1770001|emb|CAA99610.1| (Z75208) autolysin sensor kinase [Bacillus subtilis] gi|2635358|emb|CAB14853.1| (Z99118) two-component sensor histidine kinase [Bacillus subtilis], score 395, E-value 1.00E-108. (579 aa)
CoaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa)
TTE0916Hypothetical protein. (79 aa)
TTE0980Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
BaeS5Sensory transduction histidine kinases; Best Blastp hit = gi|10172986|dbj|BAB04092.1| (AP001508) two-component sensor histidine kinase [Bacillus halodurans], score 243, E-value 4.00E-63. (462 aa)
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.