STRINGSTRING
Ta0011 Ta0011 Ta0013 Ta0013 Ta0050 Ta0050 Ta0053 Ta0053 Ta0054 Ta0054 Ta0055 Ta0055 Ta0091 Ta0091 Ta0092 Ta0092 Ta0322 Ta0322 Ta0323 Ta0323 Ta0343 Ta0343 Ta0358 Ta0358 Ta0359 Ta0359 Ta0360 Ta0360 Ta0361 Ta0361 Ta0432 Ta0432 Ta0433 Ta0433 Ta0434 Ta0434 Ta0444 Ta0444 Ta0445 Ta0445 Ta0515 Ta0515 Ta0534 Ta0534 Ta0566 Ta0566 Ta0589 Ta0589 Ta0605 Ta0605 Ta0937 Ta0937 Ta0942 Ta0942 Ta0948 Ta0948 Ta1031 Ta1031 Ta1033 Ta1033 Ta1057 Ta1057 Ta1059 Ta1059 Ta1073 Ta1073 Ta1084 Ta1084 Ta1092 Ta1092 Ta1098 Ta1098 Ta1112 Ta1112 Ta1114 Ta1114 Ta1115 Ta1115 Ta1116 Ta1116 Ta1131 Ta1131 Ta1167 Ta1167 Ta1190 Ta1190 Ta1203 Ta1203 Ta1205 Ta1205 Ta1241 Ta1241 Ta1249 Ta1249 Ta1250 Ta1250 Ta1251 Ta1251 Ta1252 Ta1252 Ta1253 Ta1253 Ta1254 Ta1254 Ta1255 Ta1255 Ta1256 Ta1256 Ta1257 Ta1257 Ta1258 Ta1258 Ta1259 Ta1259 Ta1261 Ta1261 Ta1262 Ta1262 Ta1265 Ta1265 Ta1266 Ta1266 Ta1267 Ta1267 Ta1268 Ta1268 Ta1269 Ta1269 Ta1270 Ta1270 Ta1271 Ta1271 Ta1286 Ta1286 Ta1291 Ta1291 Ta1295 Ta1295 Ta1297 Ta1297 Ta1439 Ta1439 Ta1492 Ta1492
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ta0011Similarity to known protein: UDP-GLUCOSE 4-EPIMERASE (EC 5.1.3.2) (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) - Corynebacterium diphtheriae; SWISSPROT:GALE_CORDIFunction: Galactose metabolism, Nucleotide sugars metabolism. (312 aa)
Ta0013Probable Fe-superoxide dismutase (sod); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (205 aa)
Ta0050Ribosomal protein S19 related protein; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
Ta0053Strong similarity to known protein: ribosomal protein L39, cytosolic [validated] - rat; PIR1:R6RT39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
Ta0054Similarity to known protein: 60S RIBOSOMAL PROTEIN L31 - Nicotiana glutinosa (Tobacco); SWISSPROT:RL31_NICGU; Belongs to the eukaryotic ribosomal protein eL31 family. (92 aa)
Ta0055Translation initiation factor eIF-6 related protein; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (189 aa)
Ta0091Probable ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa)
Ta0092Probable 30S RIBOSOMAL PROTEIN S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (184 aa)
Ta0322Probable translation initiation factor aIF-2, gamma chain; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (411 aa)
Ta0323Similarity to known protein: ribosomal protein S6.1, cytosolic - maize; PIR2:T04334; Belongs to the eukaryotic ribosomal protein eS6 family. (124 aa)
Ta0343Similarity to known protein: Vibrio vulnificus nucleotide sugar epimerase gene, complete cds; TREMBL:AF059755_1. (307 aa)
Ta0358Probable 50S ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa)
Ta0359Acidic ribosomal protein P0 related protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (314 aa)
Ta0360Probable 50S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (217 aa)
Ta0361Probable 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (152 aa)
Ta0432Probable 30S ribosomal protein S9; Strong similarity to known protein; Belongs to the universal ribosomal protein uS9 family. (129 aa)
Ta0433Probable 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (136 aa)
Ta0434Strong similarity to known protein: 50S RIBOSOMAL PROTEIN L18E (HL29) (L19) - Haloarcula marismortui (Halobacterium marismortui); SWISSPROT:R18E_HALMA; Belongs to the eukaryotic ribosomal protein eL18 family. (120 aa)
Ta0444Probable translation elongation factor aEF-1, alpha chain; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (427 aa)
Ta0445Probable 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (104 aa)
Ta0515Probable signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (456 aa)
Ta0534Peptide chain release factor subunit 1 related protein; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (417 aa)
Ta0566Conserved hypothetical protein; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa)
Ta0589Strong similarity to known protein: ssu ribosomal protein s17e (rps17e) PAB7207 - Pyrococcus abyssi (strain Orsay); PIR:F75128; Belongs to the eukaryotic ribosomal protein eS17 family. (75 aa)
Ta0605Translation initiation factor eIF-2, beta chain related protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. (209 aa)
Ta0937prolyl-tRNA synthetase related protein; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (462 aa)
Ta0942glutamyl-tRNA synthetase related protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (550 aa)
Ta0948Similarity to unknown protein: conserved hypothetical protein MTH729 - Methanobacterium thermoautotrophicum (strain Delta H); PIR:D69197. Relation: ethylene-responsive transcriptional coactivator related protein conserved hypothetical protein TREMBLNEW:AF096246_1. (141 aa)
Ta1031Probable 30S ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
Ta1033Probable ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (171 aa)
Ta1057Probable 50S ribosomal protein L10; Strong similarity to known protein: Bos taurus ribosomal protein (QM) mRNA, complete cds; TREMBL:AF143815_1; Belongs to the universal ribosomal protein uL16 family. (169 aa)
Ta1059Translation initiation factor eIF-5a related protein; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (129 aa)
Ta1073Strong similarity to known protein: sulfolipid biosynthesis protein SQD1, chloroplast [validated] - Arabidopsis thaliana; PIR:T05311. (389 aa)
Ta1084Strong similarity to unknown protein: hypothetical protein PH1269 - Pyrococcus horikoshii; PIR:B71072. (161 aa)
Ta1092Similarity to known protein: ribosomal protein S24.e, cytosolic - yeast (Saccharomyces cerevisiae); PIR:S48410; Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa)
Ta1098Cell division protein pelota related protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (339 aa)
Ta1112Translation initiation factor IF-2 related protein; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (589 aa)
Ta1114Probable 50S ribosomal protein L24E; Binds to the 23S rRNA. (67 aa)
Ta1115Probable 30S ribosomal protein S28; Strong similarity to known protein: Prunus persica rps28.2 genegene: rps28.2; product: ribosomal protein S28; Prunus persica rps28.2 gene; TREMBL:PPE012656_1; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
Ta1116Probable 50S ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (121 aa)
Ta1131Strong similarity to known protein: 40s ribosomal protein s13 - fission yeast (Schizosaccharomyces pombe); PIR:S26296. (145 aa)
Ta1167Similarity to known protein: ribosomal protein S0.e.B, cytosolic - yeast (Saccharomyces cerevisiae); PIR:S14051; Belongs to the eukaryotic ribosomal protein eS1 family. (215 aa)
Ta1190Strong similarity to known protein: ribosomal protein S2 [validated] - Haloarcula marismortui; PIR:G41715; Belongs to the universal ribosomal protein uS2 family. (199 aa)
Ta1203Translation initiation factor eIF-2, alpha subunit related protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (254 aa)
Ta120550S ribosomal protein L44 related protein; Binds to the 23S rRNA. (93 aa)
Ta1241Probable ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (54 aa)
Ta1249Ribosomal protein L15 related protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
Ta1250Similarity to known protein: 60S RIBOSOMAL PROTEIN L28 (L27A) (L29) (YL24) (RP62) - Saccharomyces cerevisiae (Baker's yeast); SWISSPROT:RL28_YEAST. (142 aa)
Ta1251Probable 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. (221 aa)
Ta1252Probable 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (163 aa)
Ta1253Probable 50S ribosomal protein L19; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa)
Ta1254Similarity to known protein: 50S RIBOSOMAL PROTEIN L32E - Sulfolobus acidocaldarius; SWISSPROT:RL32_SULAC; Belongs to the eukaryotic ribosomal protein eL32 family. (130 aa)
Ta1255Probable 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
Ta1256Probable 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (129 aa)
Ta1257Probable 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles. (53 aa)
Ta125850S RIBOSOMAL PROTEIN L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (170 aa)
Ta1259Known protein: ribosomal protein s4e - Thermoplasma acidophilum; PIR:T37467; Belongs to the eukaryotic ribosomal protein eS4 family. (237 aa)
Ta1261Probable 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
Ta1262Probable ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (109 aa)
Ta1265Probable 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (225 aa)
Ta1266Probable 50S ribosomal protein L22; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (151 aa)
Ta1267Probable 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (151 aa)
Ta1268Probable 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (233 aa)
Ta1269Probable 50S ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (84 aa)
Ta1270Probable 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa)
Ta127150S ribosomal protein L3 related protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (331 aa)
Ta1286Known protein: ribosomal protein L15.eR - Thermoplasma acidophilum; PIR:JC4150; Belongs to the eukaryotic ribosomal protein eL15 family. (207 aa)
Ta1291Strong similarity to unknown protein: conserved hypothetical protein MTH685 - Methanobacterium thermoautotrophicum (strain Delta H); PIR:C69191. (187 aa)
Ta1295Probable ribosomal protein L37; Binds to the 23S rRNA. (80 aa)
Ta1297Strong similarity to known protein: ribosomal protein L21.eR [validated] - Haloarcula marismortui; PIR1:R5HS31; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa)
Ta1439Methionyl aminopeptidase related protein; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (293 aa)
Ta1492Strong similarity to known protein: RNase L inhibitor (clone 8) - human; PIR:S63672. (589 aa)
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.