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Ta1361 Ta1361 Ta0684 Ta0684 Ta0762 Ta0762 Ta0791 Ta0791 Ta0792 Ta0792 Ta0809 Ta0809 Ta0854 Ta0854 Ta0878 Ta0878 Ta0880 Ta0880 Ta0882 Ta0882 Ta0889 Ta0889 Ta0893 Ta0893 Ta0896 Ta0896 Ta0944 Ta0944 Ta1044 Ta1044 Ta1064 Ta1064 Ta1066 Ta1066 Ta1075 Ta1075 Ta1091 Ta1091 Ta1103 Ta1103 Ta1107 Ta1107 Ta1113 Ta1113 Ta1136 Ta1136 Ta1139 Ta1139 Ta1194 Ta1194 Ta1242 Ta1242 Ta1305 Ta1305 Ta1315 Ta1315 Ta1318 Ta1318 Ta1319 Ta1319 Ta1347 Ta1347 Ta1358 Ta1358 Ta0633 Ta0633 Ta1367 Ta1367 Ta1419 Ta1419 Ta1429 Ta1429 Ta0523 Ta0523 Ta0575 Ta0575 Ta0594 Ta0594 Ta0598 Ta0598 Ta0001 Ta0001 Ta0002 Ta0002 Ta0003 Ta0003 Ta0004 Ta0004 Ta0005 Ta0005 Ta0006 Ta0006 Ta0044 Ta0044 Ta0056 Ta0056 Ta0060 Ta0060 Ta0073 Ta0073 Ta0081 Ta0081 Ta0082 Ta0082 Ta0090 Ta0090 Ta0119 Ta0119 Ta0219 Ta0219 Ta0303 Ta0303 Ta0309 Ta0309 Ta0313 Ta0313 Ta0332 Ta0332 Ta0403 Ta0403 Ta0616 Ta0616 Ta0404 Ta0404 Ta0406 Ta0406 Ta0413 Ta0413 Ta0421 Ta0421 Ta0479 Ta0479 Ta0486 Ta0486
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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Ta1361Probable GMP synthase; Catalyzes the synthesis of GMP from XMP. (310 aa)
Ta0684Deoxyribose-phosphate aldolase related protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (246 aa)
Ta07622-phosphoglycerate kinase related protein; Phosphorylates mevalonate 3-phosphate to form mevalonate 3,5- bisphosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5- phosphate. (202 aa)
Ta0791Probable carbamoyl-phosphate synthase, large subunit; Strong similarity to known protein: carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus caldolyticus; PIR:I40169. (1047 aa)
Ta0792Similarity to known protein: carbamoyl-phosphate synthase, small (or glutamine) subunit (carA) homolog - Archaeoglobus fulgidus; PIR:H69408Function: Urea cycle and metabolism of amino groups, Glutamate metabolism, Arginine and proline metabolism, Nitrogen metabolism; Belongs to the CarA family. (353 aa)
Ta0809Probable aldehyde dehydrogenase; NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes. (493 aa)
Ta0854Probable phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (182 aa)
Ta0878Ribose-5-phosphate isomerase related protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (241 aa)
Ta0880Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...] (287 aa)
Ta0882Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (401 aa)
Ta0889DNA/pantothenate metabolism flavoprotein related protein; Similarity to known protein: Bradyrhizobium japonicum UbiE (ubiE) gene, partial cds; AarF (aarF), panthotenate metabolism flavoprotein (dfp), deoxyuridine-triphosphatase(dut), putative sensor protein (bdfA), GalF-like (galF), hypotheticalprotein genes, complete cds; putative helicase 2 gene, partial cds; andunknown genes; TREMBL:AF042096_2. (394 aa)
Ta0893Hypothetical protein; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. (405 aa)
Ta0896Similarity to known protein: pyruvate kinase (EC 2.7.1.40) [validated] - Bacillus licheniformis; PIR:JC4220. (544 aa)
Ta0944GMP synthase related protein; Catalyzes the synthesis of GMP from XMP. (181 aa)
Ta1044Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa)
Ta1064Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (220 aa)
Ta1066Phosphoribosylformylglycinamidine synthase related protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (759 aa)
Ta1075Probable 3-phosphoglycerate kinase; Strong similarity to known protein: phosphoglycerate kinase (EC 2.7.2.3) [validated] - Methanothermus fervidus (fragment); PIR:PN0008. (408 aa)
Ta1091Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (156 aa)
Ta1103Strong similarity to known protein: glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) - Methanothermus fervidus; PIR:JT0286. (338 aa)
Ta1107Phosphoribosylaminoimidazole carboxylase related protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa)
Ta1113Probable nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (148 aa)
Ta1136Similarity to unknown protein: transmembrane oligosaccharyl transferase homolog - Archaeoglobus fulgidus; PIR:D69297. (2081 aa)
Ta1139Aut related protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (142 aa)
Ta1194Conserved hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. In the N-terminal section; belongs to the eukaryotic CoaD family. (328 aa)
Ta1242Probable amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (474 aa)
Ta1305Hypothetical protein; Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5- phosphate. (318 aa)
Ta1315Probable ribulose-5-phosphate 3-epimerase; Strong similarity to known protein: RIBULOSE-PHOSPHATE 3-EPIMERASE PRECURSOR (EC 5.1.3.1) (PENTOSE-5-PHOSPHATE 3-EPIMERASE) (PPE) (RPE) (R5P3E) - Oryza sativa (Rice); SWISSPROT:RPE_ORYSA. (211 aa)
Ta1318Phosphoribosylformylglycinamidine synthase I related protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...] (289 aa)
Ta1319Cad protein (human), dihydroorotase domain related protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (414 aa)
Ta1347Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. (214 aa)
Ta1358Glycine dehydrogenase (decarboxylating) related protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (433 aa)
Ta0633Similarity to known protein: glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) chain A, anaerobic [validated] - Escherichia coli; PIR:DEECNA. (422 aa)
Ta1367Probable adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (460 aa)
Ta1419Conserved hypothetical protein; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency; Belongs to the PGI/PMI family. (310 aa)
Ta1429Similarity to unknown protein: hypothetical protein CT632 - Chlamydia trachomatis (serotype D, strain UW3/Cx); PIR:D71489; Belongs to the UPF0159 family. (499 aa)
Ta0523Strong similarity to known protein: adenylosuccinate lyase (EC 4.3.2.2) - Bacillus subtilis; PIR1:WZBSDSFunction: Purine metabolism, Alanine and Aspartate metabolism. (455 aa)
Ta0575Strong similarity to known protein: probable aspartate carbamoyltransferase catalytic chain - Pyrococcus horikoshii; PIR:A71119. (305 aa)
Ta0594Similarity to known protein: phosphoribosylamine--glycine ligase (EC 6.3.4.13) - Methanococcus jannaschii; PIR:A64417. (205 aa)
Ta0598dCTP deaminase related protein; Catalyzes the deamination of dCTP to dUTP. (183 aa)
Ta0001ATP synthase (subunit E) related protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa)
Ta0002ATP synthase (subunit C) related protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (356 aa)
Ta0003ATP synthase(subunit F) related protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (104 aa)
Ta0004Probable ATP synthase, subunit A (intein containing); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (764 aa)
Ta0005Probable ATP synthase (subunit B); Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (476 aa)
Ta0006Vacuolar proton-ATPase subunit D related protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa)
Ta0044Probable CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (540 aa)
Ta0056Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (171 aa)
Ta0060Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. (491 aa)
Ta0073Orotidine-5'-monophosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa)
Ta0081Conserved hypothetical protein; Similarity to unknown protein: thymidylate kinase (tmk) homolog - Archaeoglobus fulgidus; PIR:E69257. (193 aa)
Ta0082Strong similarity to known protein: phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) - Arabidopsis thaliana; PIR:S37105. (203 aa)
Ta0090Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. (338 aa)
Ta0119RIBOSE-PHOSPHATE PYROPHOSPHOKINASE related protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (237 aa)
Ta0219Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
Ta0303Probable phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (160 aa)
Ta0309Similarity to known protein: PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (EC 6.3.2.6)(SAICAR SYNTHETASE) - Saccharomyces cerevisiae (Baker's yeast); SWISSPROT:PUR7_YEAST. (314 aa)
Ta0313Triosephosphate isomerase related protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (216 aa)
Ta0332Purine-nucleoside phosphorylase related protein; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (261 aa)
Ta0403Nife hydrogenase gamma subunit related protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (250 aa)
Ta0616Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (223 aa)
Ta0404DIHYDROOROTATE DEHYDROGENASE B related protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (300 aa)
Ta0406Similarity to known protein: hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) - Pseudomonas sp; PIR:A44756. (437 aa)
Ta0413Conserved hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (404 aa)
Ta0421Probable acetyl-coenzyme-A synthetase; Strong similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) [validated] - Methanothrix soehngenii; PIR:A41043. (647 aa)
Ta0479Similarity to known protein: GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING](EC 2.6.1.16) (GFAT) (NODULATION PROTEIN M) - Rhizobium leguminosarum (biovar viciae); SWISSPROT:NODM_RHILVFunction: glutamate metabolism. (346 aa)
Ta0486Uridylate kinase related protein; Catalyzes the reversible phosphorylation of UMP to UDP. (229 aa)
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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