STRINGSTRING
Ta0123 Ta0123 Ta0208 Ta0208 Ta0229 Ta0229 Ta0259 Ta0259 Ta0260 Ta0260 Ta0313 Ta0313 Ta0413 Ta0413 Ta0421 Ta0421 Ta0439 Ta0439 Ta0568 Ta0568 Ta0626 Ta0626 Ta0674 Ta0674 Ta0769 Ta0769 Ta0772 Ta0772 Ta0773 Ta0773 Ta0823 Ta0823 Ta0825 Ta0825 Ta0882 Ta0882 Ta0886 Ta0886 Ta0896 Ta0896 Ta0911 Ta0911 Ta1075 Ta1075 Ta1103 Ta1103 Ta1153 Ta1153 Ta1347 Ta1347 Ta1419 Ta1419 Ta1428 Ta1428 Ta1435 Ta1435 Ta1436 Ta1436 Ta1437 Ta1437 Ta1438 Ta1438 Ta1508 Ta1508
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ta0123Probable phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (614 aa)
Ta0208Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Escherichia coli; PIR:DEECLP. (451 aa)
Ta0229acetyl-CoA synthetase related protein; Similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) - Emericella nidulans; PIR:SYASAA. (619 aa)
Ta0259Probable pyruvate ferredoxin oxidoreductase, alpha subunit; Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) alpha chain [validated] - Sulfolobus sp. (strain 7); PIR:JC4919. (588 aa)
Ta0260Probable pyruvate ferredoxin oxidoreductase, beta subunit; Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) beta chain - Methanobacterium thermoautotrophicum (strain Delta H); PIR:H69170. (285 aa)
Ta0313Triosephosphate isomerase related protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (216 aa)
Ta0413Conserved hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (404 aa)
Ta0421Probable acetyl-coenzyme-A synthetase; Strong similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) [validated] - Methanothrix soehngenii; PIR:A41043. (647 aa)
Ta0439Piperideine-6-carboxilic acid dehydrogenase related protein; Strong similarity to known protein: Malus domestica mRNA for protein abundantly expressed during apple fruitdevelopment, complete cds; TREMBL:D88434_1. Relation: strong similarity to a protein abundantly expressed during apple fruit development, function not known, TREMBL:D88434_1. (512 aa)
Ta0568Similarity to known protein: phosphomannomutase (pmm) homolog - Archaeoglobus fulgidus; PIR:B69307; Belongs to the phosphohexose mutase family. (453 aa)
Ta0626Strong similarity to known protein: PYRUVATE/KETOISOVALERATE OXIDOREDUCTASES COMMON GAMMA SUBUNIT[INCLUDES: PYRUVATE SYNTHASE SUBUNIT PORC (EC 1.2.7.1) (PYRUVATEOXIDOREDUCTASE GAMMA CHAIN) (POR) (PYRUVIC-FERREDOXIN OXIDOREDUCTASEGAMMA SUBUNIT); KETOISOVALERATE OXIDOREDUCTASE SUBUNIT VORC(EC 1.-.-.-) (VOR) (2-OXOISOVALERATE OXIDOREDUCTASE GAMMA CHAIN) (2-OXOISOVALERATE-FERREDOXIN OXIDOREDUCTASE GAMMA SUBUNIT)] - Pyrococcus furiosus; SWISSNEW:PORC_PYRFUFunction: Pyruvate metabolism, Propanoate metabolism, Butanoate metabolism, Reductive carboxylate cycle (CO2 fixation). (195 aa)
Ta0674Conserved hypothetical protein; Weak similarity to unknown protein. (275 aa)
Ta0769Probable acetyl-coenzyme A synthetase; Strong similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) [validated] - Methanothrix soehngenii; PIR:A41043. (599 aa)
Ta0772Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) beta chain - Sulfolobus sp. (strain 7); PIR:JC4920. (309 aa)
Ta0773Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) alpha chain [validated] - Sulfolobus sp. (strain 7); PIR:JC4919. (629 aa)
Ta0823Weak similarity to known protein. (190 aa)
Ta0825Glucose kinase related protein; Similarity to known protein: Bacillus megaterium glk gene; TREMBL:BMGLUCKIN_2. (324 aa)
Ta0882Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (401 aa)
Ta0886Strong similarity to unknown protein: pyruvate, orthophosphate dikinase (EC 2.7.9.1) - Thermotoga maritima (strain MSB8); PIR:F72397Function: Pyruvate metabolism, Carbon ixation. (886 aa)
Ta0896Similarity to known protein: pyruvate kinase (EC 2.7.1.40) [validated] - Bacillus licheniformis; PIR:JC4220. (544 aa)
Ta0911Similarity to unknown protein: hypothetical 34K protein (glnA-fdhE intergenic region) - Escherichia coli; PIR:S40823. (288 aa)
Ta1075Probable 3-phosphoglycerate kinase; Strong similarity to known protein: phosphoglycerate kinase (EC 2.7.2.3) [validated] - Methanothermus fervidus (fragment); PIR:PN0008. (408 aa)
Ta1103Strong similarity to known protein: glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) - Methanothermus fervidus; PIR:JT0286. (338 aa)
Ta1153Probable acetyl-CoA synthetase; Strong similarity to known protein: Giardia intestinalis acetyl-CoA synthetase gene, complete cds; TREMBL:AF107206_1. (698 aa)
Ta1347Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. (214 aa)
Ta1419Conserved hypothetical protein; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency; Belongs to the PGI/PMI family. (310 aa)
Ta1428Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa)
Ta1435Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Bacillus subtilis; PIR:E36718. (436 aa)
Ta1436Probable lipoamide acyltransferase; Strong similarity to known protein: Myxococcus xanthus lipoic acid synthetase precursor, lipoamideacyltransferase, and lipoate-protein ligase B genes, complete cds; andunknown genes; TREMBL:AF153678_2. (400 aa)
Ta1437Strong similarity to known protein: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) chain E1-beta - Pseudomonas putida; PIR:DEPSEB. (319 aa)
Ta1438Strong similarity to known protein: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) alpha chain precursor - human; PIR:DEHUXAORF_prediction: The N-terminus of this protein is short by 60aa compared to other proteins, sequence analysis clearly rules out an elongated N-terminus. (337 aa)
Ta1508Probable SA protein; Strong similarity to known protein: Mus musculus SA mRNA, complete cds; TREMBL:AB022340_1. (528 aa)
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
Server load: low (22%) [HD]