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Ta0045 Ta0045 Ta0229 Ta0229 Ta0413 Ta0413 Ta0421 Ta0421 Ta0425 Ta0425 Ta0453 Ta0453 Ta0626 Ta0626 Ta0769 Ta0769 Ta0811 Ta0811 Ta0823 Ta0823 Ta0858 Ta0858 Ta0882 Ta0882 Ta0936 Ta0936 Ta0952 Ta0952 Ta1109 Ta1109 Ta1347 Ta1347 Ta1428 Ta1428 Ta1432 Ta1432 Ta1508 Ta1508 Ta1509 Ta1509
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ta0045Probable formate dehydrogenase, alpha subunit; Strong similarity to known protein: Methanobacterium thermoformicicum formate dehydrogenase operon and flankingregions, formate transporter (fdhC), formate dehydrogenase alpha subunit(fdhA) and formate dehydrogenase beta subunit (fdhB) genes, complete cds; TREMBL:MT52681_3Function: Glyoxylate and dicarboxylate metabolism, Methane metabolism. (702 aa)
Ta0229acetyl-CoA synthetase related protein; Similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) - Emericella nidulans; PIR:SYASAA. (619 aa)
Ta0413Conserved hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (404 aa)
Ta0421Probable acetyl-coenzyme-A synthetase; Strong similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) [validated] - Methanothrix soehngenii; PIR:A41043. (647 aa)
Ta0425Similarity to known protein: formate dehydrogenase (EC 1.2.1.2) H (hydrogenase-linked) - Escherichia coli; PIR1:DEECFS. (996 aa)
Ta0453Glycerate kinase related protein; Similarity to known protein: Methylobacterium extorquens putative glycerate kinase and pyruvate kinase(pykA) genes, complete cds; TREMBLNEW:MEU87316_4. (396 aa)
Ta0626Strong similarity to known protein: PYRUVATE/KETOISOVALERATE OXIDOREDUCTASES COMMON GAMMA SUBUNIT[INCLUDES: PYRUVATE SYNTHASE SUBUNIT PORC (EC 1.2.7.1) (PYRUVATEOXIDOREDUCTASE GAMMA CHAIN) (POR) (PYRUVIC-FERREDOXIN OXIDOREDUCTASEGAMMA SUBUNIT); KETOISOVALERATE OXIDOREDUCTASE SUBUNIT VORC(EC 1.-.-.-) (VOR) (2-OXOISOVALERATE OXIDOREDUCTASE GAMMA CHAIN) (2-OXOISOVALERATE-FERREDOXIN OXIDOREDUCTASE GAMMA SUBUNIT)] - Pyrococcus furiosus; SWISSNEW:PORC_PYRFUFunction: Pyruvate metabolism, Propanoate metabolism, Butanoate metabolism, Reductive carboxylate cycle (CO2 fixation). (195 aa)
Ta0769Probable acetyl-coenzyme A synthetase; Strong similarity to known protein: acetate--CoA ligase (EC 6.2.1.1) [validated] - Methanothrix soehngenii; PIR:A41043. (599 aa)
Ta0811Similarity to known protein: glycine hydroxymethyltransferase (EC 2.1.2.1) - Methanobacterium thermoautotrophicum (strain Marburg); PIR:S62190Function: involved in glycine, serine and threonine metabolism, also involved in vitamin B6 metabolism. (387 aa)
Ta0823Weak similarity to known protein. (190 aa)
Ta0858Similarity to known protein: GLYCERATE DEHYDROGENASE (EC 1.1.1.29) (NADH-DEPENDENT HYDROXYPYRUVATEREDUCTASE) (HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATEREDUCTASE) (HPR-A) - Methylobacterium extorquens; SWISSPROT:DHGY_METEX; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (303 aa)
Ta0882Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (401 aa)
Ta0936Conserved hypothetical protein; Weak similarity to known protein. Relation: similar to phosphoserine phosphatase PIR:S53931. (212 aa)
Ta0952Probable malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (325 aa)
Ta1109Similarity to unknown protein: hypothetical protein PH1238 - Pyrococcus horikoshii; PIR:H71067. (203 aa)
Ta1347Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. (214 aa)
Ta1428Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa)
Ta1432Similarity to unknown protein: conserved hypothetical protein - Thermotoga maritima (strain MSB8); PIR:F72334; Belongs to the ComB family. (220 aa)
Ta1508Probable SA protein; Strong similarity to known protein: Mus musculus SA mRNA, complete cds; TREMBL:AB022340_1. (528 aa)
Ta1509Probable glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (436 aa)
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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