STRINGSTRING
Ta0026 Ta0026 Ta0059 Ta0059 Ta0080 Ta0080 Ta0112 Ta0112 Ta0113 Ta0113 Ta0116 Ta0116 Ta0117 Ta0117 Ta0119 Ta0119 Ta0139 Ta0139 Ta0169 Ta0169 Ta0247 Ta0247 Ta0282 Ta0282 Ta0283 Ta0283 Ta0284 Ta0284 Ta0285 Ta0285 Ta0313 Ta0313 Ta0315 Ta0315 Ta0363 Ta0363 Ta0364 Ta0364 Ta0413 Ta0413 Ta0414 Ta0414 Ta0495 Ta0495 Ta0529 Ta0529 Ta0530 Ta0530 Ta0531 Ta0531 Ta0535 Ta0535 Ta0616 Ta0616 Ta0617 Ta0617 Ta0618 Ta0618 Ta0649 Ta0649 Ta0650 Ta0650 Ta0669 Ta0669 Ta0691 Ta0691 Ta0788 Ta0788 Ta0803 Ta0803 Ta0804 Ta0804 Ta0805 Ta0805 Ta0806 Ta0806 Ta0807 Ta0807 Ta0808 Ta0808 Ta0811 Ta0811 Ta0819 Ta0819 Ta0823 Ta0823 Ta0824 Ta0824 Ta0878 Ta0878 Ta0882 Ta0882 Ta0896 Ta0896 Ta0915 Ta0915 Ta0934 Ta0934 Ta0936 Ta0936 Ta0977 Ta0977 Ta0978 Ta0978 Ta1075 Ta1075 Ta1103 Ta1103 Ta1179 Ta1179 Ta1315 Ta1315 Ta1330 Ta1330 Ta1347 Ta1347 Ta1428 Ta1428 Ta1498 Ta1498 Ta1509 Ta1509
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ta0026Similarity to known protein: threonine synthase (EC 4.2.99.2) thrC - Bacillus subtilis; PIR2:A25364Function: Glycine, serine and threonine metabolism. (316 aa)
Ta0059Conserved hypothetical protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (400 aa)
Ta0080Similarity to known protein: cystathionine gamma-lyase (EC 4.4.1.1) - rat; PIR:A49864Function: Methionine metabolism, Selenoamino acid metabolism, Nitrogen metabolism. (384 aa)
Ta0112Strong similarity to known protein: aconitate hydratase (EC 4.2.1.3) - Legionella pneumophila; PIR:B48642. (869 aa)
Ta0113Strong similarity to known protein: threonine dehydratase (EC 4.2.1.16), biodegradative [validated] - Escherichia coli; PIR:DWECTD. (406 aa)
Ta0116Hypothetical protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (228 aa)
Ta0117Strong similarity to known protein: isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) - Bacillus subtilis; PIR:I40382. (405 aa)
Ta0119RIBOSE-PHOSPHATE PYROPHOSPHOKINASE related protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (237 aa)
Ta0139Pyrroline-5-carboxylate reductase related protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (279 aa)
Ta0169Known protein: citrate (si)-synthase (EC 4.1.3.7) - Thermoplasma acidophilum; PIR:YKYT. (385 aa)
Ta0247Strong similarity to known protein: Synechocystis sp. ccmA gene for 32.4kD protein and ORF271 for 29.5kDprotein, complete cds; TREMBL:SSCCMA_1. (285 aa)
Ta02823-phosphoshikimate 1-carboxyvinyltransferase related protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (410 aa)
Ta0283Conserved hypothetical protein; Similarity to unknown protein: homoserine kinase PAB0301 - Pyrococcus abyssi (strain Orsay); PIR:F75161. (268 aa)
Ta0284Shikimate 5-dehydrogenase related protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa)
Ta02853-dehyroquinate synthase related protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (360 aa)
Ta0313Triosephosphate isomerase related protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (216 aa)
Ta0315Similarity to known protein: Mus musculus asparagine synthetase mRNA, complete cds; TREMBL:MM38940_1. (236 aa)
Ta0363Similarity to known protein: Ustilgo maydis aspartate semialdehyde dehydrogenase (ASADH) mRNA, completecds; TREMBL:UM44901_1. (338 aa)
Ta0364Similarity to known protein: A.thaliana mRNA for aspartate kinase; TREMBL:ATAKLYS1_1. (272 aa)
Ta0413Conserved hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (404 aa)
Ta0414Similarity to known protein: GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13) (GLUTAMATESYNTHASE BETA SUBUNIT) (NADPH-GOGAT) (GLTS BETA CHAIN) - Escherichia coli; SWISSPROT:GLTD_ECOLI. (484 aa)
Ta0495Similarity to known protein: threonine synthase (EC 4.2.99.2) thrC - Bacillus subtilis; PIR:A25364. (334 aa)
Ta0529Probable aspartate aminotransferase; Strong similarity to known protein: aspartate transaminase (EC 2.6.1.1) - Sulfolobus solfataricus; PIR:S07088Function: Glutamate metabolism, Alanine and Aspartate metabolism Cysteine metabolism, Carbon fixation. (377 aa)
Ta0530Homoserine kinase related protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
Ta0531Probable cystathionine gamma-synthase; Strong similarity to known protein: Arabidopsis thaliana gene for cystathionine gamma-synthase, complete cds; TREMBL:AB010888_1Function: Involved in Cysteine metabolism, Methionine metabolism, Glycine, serine and threonine metabolism, Selenoamino acid metabolism. EC Numbers and enzyme names are mixed up, homologs are called cystathionine gamma-synthase (EC 4.2.99.9) and cystathionine gamma lyase (EC 4.4.1.-). (380 aa)
Ta0535Similarity to known protein: cysteine synthase (EC 4.2.99.8) B - Campylobacter jejuni; PIR:JC6185. (299 aa)
Ta0616Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (223 aa)
Ta0617Probable transketolase; Strong similarity to known protein: TRANSKETOLASE (EC 2.2.1.1) (TK) (P68) - Mus musculus (Mouse); SWISSPROT:TKT_MOUSE. (316 aa)
Ta0618Probable transketolase; Strong similarity to known protein: TRANSKETOLASE (EC 2.2.1.1) (TK) (P68) - Mus musculus (Mouse); SWISSPROT:TKT_MOUSE. (273 aa)
Ta0649Similarity to known protein: argininosuccinate lyase (EC 4.3.2.1) - goose; PIR:JN0486. (433 aa)
Ta0650Strong similarity to known protein: argininosuccinate synthase (EC 6.3.4.5) - Methanococcus vannielii; PIR:AJMXRV; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
Ta0669Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (424 aa)
Ta0691Acetolactate synthase, large chain related protein; Similarity to known protein: acetolactate synthase (EC 4.1.3.18) - Caulobacter crescentus; PIR:I40666. Relation: similarity to acetolactate synthase (EC 4.1.3.18) - Caulobacter crescentus; I40666. Function: Valine, leucine and isoleucine biosynthesis, Butanoate metabolism, C5-Branched dibasic acid metabolism, Pantothenate and CoA biosynthesis. (553 aa)
Ta0788Diaminopimelate decarboxylase related protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (436 aa)
Ta0803Similarity to known protein: TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20).TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20) - Sulfolobus solfataricus.Sulfolobus solfataricus; SWISSPROT:TRPA_SULSO. (217 aa)
Ta0804Anthranilate phosphoribosyltransferase related protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (322 aa)
Ta0805Weak similarity to known protein. Relation: weak similarity to phosphoribosylanthranilate isomerase - Aquifex aeolicus, PIR:A70478; Belongs to the TrpF family. (179 aa)
Ta0806Similarity to known protein: anthranilate synthase (EC 4.1.3.27) component I - Clostridium thermocellum; PIR:JX0065. (356 aa)
Ta0807Probable anthranilate synthase component II; Strong similarity to known protein: Pyrococcus kodakaraensis trp operon genes (trpC, trpD, trpE, trpG, trpF, trpB, trpA), complete cds; TREMBL:AB030011_4. (183 aa)
Ta0808Similarity to known protein: indole-3-glycerol-phosphate synthase (EC 4.1.1.48) TrpC - Sulfolobus solfataricus; PIR:C40635; Belongs to the TrpC family. (237 aa)
Ta0811Similarity to known protein: glycine hydroxymethyltransferase (EC 2.1.2.1) - Methanobacterium thermoautotrophicum (strain Marburg); PIR:S62190Function: involved in glycine, serine and threonine metabolism, also involved in vitamin B6 metabolism. (387 aa)
Ta0819Probable citrate (si)-synthase; Strong similarity to known protein: CITRATE SYNTHASE (EC 4.1.3.7) - Thermoplasma acidophilum; SWISSPROT:CISY_THEAC. (391 aa)
Ta0823Weak similarity to known protein. (190 aa)
Ta0824Probable chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa)
Ta0878Ribose-5-phosphate isomerase related protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (241 aa)
Ta0882Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (401 aa)
Ta0896Similarity to known protein: pyruvate kinase (EC 2.7.1.40) [validated] - Bacillus licheniformis; PIR:JC4220. (544 aa)
Ta0915Chorismate mutase/prephenate dehydratase related protein; Similarity to known protein: Pseudomonas stutzeri gyrase A subunit (gyrA) gene, partial cds;3-phosphoserine aminotransferase (serC), chorismate mutase/prephenatedehydratase (aroQp/pheA), imidazole acetol phosphate aminotransferase(hisHb), and cyclohexadienyl dehydrogenase (tyrAc) genes, complete cds; and5-enolpyruvylshikmate 3-P synthase (aroF) gene, partial cds; TREMBL:AF038578_3. (277 aa)
Ta0934Similarity to known protein: acetylornithine deacetylase (EC 3.5.1.16) - Escherichia coli; PIR:B42377Function: Urea cycle and metabolism of amino groups. (399 aa)
Ta0936Conserved hypothetical protein; Weak similarity to known protein. Relation: similar to phosphoserine phosphatase PIR:S53931. (212 aa)
Ta0977Methionine synthase (cobalamin-independent) related protein; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (343 aa)
Ta0978Conserved hypothetical protein; Similarity to unknown protein: tetrahydropteroyltriglutamate methyltransferase PAB2361 - Pyrococcus abyssi (strain Orsay); PIR:B75138. (290 aa)
Ta1075Probable 3-phosphoglycerate kinase; Strong similarity to known protein: phosphoglycerate kinase (EC 2.7.2.3) [validated] - Methanothermus fervidus (fragment); PIR:PN0008. (408 aa)
Ta1103Strong similarity to known protein: glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) - Methanothermus fervidus; PIR:JT0286. (338 aa)
Ta1179Similarity to known protein: HOMOSERINE DEHYDROGENASE (EC 1.1.1.3) (HDH) - Bacillus subtilis; SWISSPROT:DHOM_BACSU. (324 aa)
Ta1315Probable ribulose-5-phosphate 3-epimerase; Strong similarity to known protein: RIBULOSE-PHOSPHATE 3-EPIMERASE PRECURSOR (EC 5.1.3.1) (PENTOSE-5-PHOSPHATE 3-EPIMERASE) (PPE) (RPE) (R5P3E) - Oryza sativa (Rice); SWISSPROT:RPE_ORYSA. (211 aa)
Ta1330Probable ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (297 aa)
Ta1347Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. (214 aa)
Ta1428Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa)
Ta1498Probable glutamine synthetase; Strong similarity to known protein: Bacillus subtilis glnR and glnA genes for GlnR protein and glutaminesynthetase, complete cds; TREMBL:BSGLNRA_2. (448 aa)
Ta1509Probable glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (436 aa)
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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