52 items (Thermoplasma volcanium) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	TVG0019502	Acylphosphatase. (90 aa)
	TVG0048225	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
	TVG0060439	Aminomethyltransferase. (359 aa)
	TVG0102621	Pyruvate dehydrogenase E3 / dihydrolipoamide dehydrogenase. (436 aa)
	TVG0103933	Pyruvate dehydrogenase E2 / dihydrolipoamide acetyltransferase. (400 aa)
	TVG0105141	Pyruvate dehydrogenase E1 /pyruvate decarboxylase. (319 aa)
	TVG0106097	2-oxoisovalerate dehydrogenase alpha subunit. (337 aa)
	TVG0196114	Aconitate hydratase. (881 aa)
	TVG0201218	Isocitrate dehydrogenase. (405 aa)
	TVG0201915	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily. (286 aa)
	TVG0204657	Phosphoenolpyrvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (589 aa)
	TVG0252956	Citrate synthase. (386 aa)
	TVG0284189	succinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (285 aa)
	TVG0285047	succinyl-CoA synthetase beta subunit. (384 aa)
	TVG0303364	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (122 aa)
	TVG0309943	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (434 aa)
	TVG0311358	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (472 aa)
	TVG0361650	Carboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (272 aa)
	TVG0362515	MMGE/PRPD family protein. (443 aa)
	TVG0388568	8-amino-7-oxononanoate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (396 aa)
	TVG0647983	1-pyrroline-5-carboxylate dehydrogenase. (515 aa)
	TVG0760262	Hypothetical protein. (123 aa)
	TVG0760633	Succinate dehydrogenase cytochrome b subunit. (140 aa)
	TVG0761062	Succinate dehydrogenase iron sulfur subunit. (240 aa)
	TVG0761794	Succinate dehydrogenase flavoprotein. (567 aa)
	TVG0773051	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (435 aa)
	TVG0774569	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (416 aa)
	TVG0785282	Malate oxidoreductase. (451 aa)
	TVG0861800	Hypothetical protein. (343 aa)
	TVG0870514	Pyruvate ferredoxin oxidoreductasse [POR] gamma subunit. (185 aa)
	TVG0870807	Pyruvate ferredoxin oxidoreductasse [POR] delta subunit. (95 aa)
	TVG0871982	Pyruvate ferredoxin oxidoreductasse [POR] alpha subunit. (392 aa)
	TVG0872869	Pyruvate ferredoxin oxidoreductasse [POR] beta subunit. (295 aa)
	TVG0881751	2-ketovalerate ferredoxin oxidoreductase [VOR] alpha subunit. (629 aa)
	TVG0882664	2-ketovalerate ferredoxin oxidoreductase [VOR] beta subunit. (309 aa)
	TVG0939251	Gamma-glutamyltransferase. (505 aa)
	TVG0959514	2-isopropylmalate/homocitrate synthetase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (344 aa)
	TVG1029756	Pyruvate orthophosphate dikinase. (886 aa)
	TVG1043834	TVG1043834 protein. (87 aa)
	TVG1044624	Lipoate-protein ligase. (262 aa)
	TVG1076108	Pyruvate kinase; Belongs to the pyruvate kinase family. (541 aa)
	TVG1110903	Aldehyde dehydrogenase. (514 aa)
	TVG1151701	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (325 aa)
	TVG1206092	acetyl-CoA synthetase. (650 aa)
	TVG1211894	Sulfide dehydrogenase alpha subunit / glutamate synthase small chain. (484 aa)
	TVG1294312	Succinyl CoA synthetase alpha subunit. (693 aa)
	TVG1328971	acetyl-CoA synthetase. (641 aa)
	TVG1331499	acetyl-CoA synthetase. (619 aa)
	TVG1405258	Ferredoxin oxidoreductase [KOR] beta subunit. (285 aa)
	TVG1406112	Ferredoxin oxidoreductase [KOR] alpha subunit. (585 aa)
	TVG1458424	Pyruvate dehydrogenase E3 / dihydrolipoamide dehydrogenase. (450 aa)
	TVG1571797	Glutamine synthetase. (462 aa)

Your Current Organism:

Thermoplasma volcanium

NCBI taxonomy Id: 273116
Other names: T. volcanium GSS1, Thermoplasma volcanium GSS1, Thermoplasma volcanium str. GSS1, Thermoplasma volcanium strain GSS1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TVG0019502	TVG1110903	gene:9380785	gene:9381878	Acylphosphatase.	Aldehyde dehydrogenase.	0.912
TVG0019502	TVG1206092	gene:9380785	gene:9381976	Acylphosphatase.	acetyl-CoA synthetase.	0.900
TVG0019502	TVG1294312	gene:9380785	gene:9382062	Acylphosphatase.	Succinyl CoA synthetase alpha subunit.	0.901
TVG0019502	TVG1328971	gene:9380785	gene:9382096	Acylphosphatase.	acetyl-CoA synthetase.	0.900
TVG0019502	TVG1331499	gene:9380785	gene:9382098	Acylphosphatase.	acetyl-CoA synthetase.	0.900
TVG0048225	TVG0060439	gene:9380811	gene:9380822	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aminomethyltransferase.	0.997
TVG0048225	TVG0102621	gene:9380811	gene:9380866	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyruvate dehydrogenase E3 / dihydrolipoamide dehydrogenase.	0.928
TVG0048225	TVG0103933	gene:9380811	gene:9380867	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyruvate dehydrogenase E2 / dihydrolipoamide acetyltransferase.	0.474
TVG0048225	TVG0196114	gene:9380811	gene:9380959	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aconitate hydratase.	0.422
TVG0048225	TVG0201218	gene:9380811	gene:9380965	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Isocitrate dehydrogenase.	0.469
TVG0048225	TVG0201915	gene:9380811	gene:9380967	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.	0.478
TVG0048225	TVG0252956	gene:9380811	gene:9381012	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Citrate synthase.	0.466
TVG0048225	TVG0303364	gene:9380811	gene:9381065	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.964
TVG0048225	TVG0309943	gene:9380811	gene:9381074	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	0.962
TVG0048225	TVG0311358	gene:9380811	gene:9381075	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.975
TVG0048225	TVG0388568	gene:9380811	gene:9381178	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	8-amino-7-oxononanoate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	0.931
TVG0048225	TVG0761794	gene:9380811	gene:9381548	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Succinate dehydrogenase flavoprotein.	0.448
TVG0048225	TVG0861800	gene:9380811	gene:9381631	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Hypothetical protein.	0.474
TVG0048225	TVG1458424	gene:9380811	gene:9382221	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyruvate dehydrogenase E3 / dihydrolipoamide dehydrogenase.	0.928
TVG0060439	TVG0048225	gene:9380822	gene:9380811	Aminomethyltransferase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.997