(34 nodes) Integral component of membrane network (Thermoplasma volcanium)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TVG0296872	Iron III dicitrate transport system permease protein. (354 aa)
	TVG0537100	ABC transport system ATP-binding protein PA. (294 aa)
	TVG0653656	Multidrug-efflux transporter. (473 aa)
	TVG0684360	Modification methylase. (985 aa)
	TVG0739837	TVG0739837 protein. (102 aa)
	TVG0751384	4-hyroxybenzoate octaprenyltransferase. (269 aa)
	TVG0819318	Multidrug resistance protein. (464 aa)
	TVG0988599	ABC-2 integral membrane protein. (267 aa)
	TVG1008755	ABC transport system permease protein PA. (252 aa)
	TVG1046096	Cofactor biosynthesis protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. (396 aa)
	TVG1095254	ABC-2 integral membrane protein. (247 aa)
	TVG1197131	ABC transport system permease protein SP1P2A. (309 aa)
	TVG1198021	ABC transport system permease protein SP1P2A. (295 aa)
	TVG1199143	ABC transport system ATP-binding protein SP1P2A. (371 aa)
	TVG1217101	Multidrug-efflux transporter. (587 aa)
	TVG1342946	Electron transfer flavoprotein. (428 aa)
	TVG1438442	Multidrug resistance protein. (480 aa)
	TVG1440155	ABC-2 integral membrane protein. (254 aa)
	TVG1503014	Multidrug resistance protein. (459 aa)
	TVG1506668	ABC transport system ATP-binding protein. (247 aa)
	TVG1579590	Hypothetical protein. (374 aa)
	TVG0517148	Hypothetical protein. (241 aa)
	TVG0506299	Multidrug-efflux transporter. (481 aa)
	TVG0489908	K+-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (209 aa)
	TVG0489285	K+-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (668 aa)
	TVG0487282	K+-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (585 aa)
	TVG0396861	4-hydroxybenzoate octaprenyltransferase. (290 aa)
	TVG0394567	Hypothetical protein. (271 aa)
	TVG0213590	ABC transport system ATP-binding protein P1P2A. (353 aa)
	TVG0212495	ABC transport system permease protein P1P2A. (268 aa)
	TVG0211687	ABC transport system permease protein P1P2A. (296 aa)
	TVG0192666	Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (183 aa)
	TVG0176458	Hypothetical protein. (275 aa)
	TVG0097142	Hypothetical protein. (592 aa)

Your Current Organism:

Thermoplasma volcanium

NCBI taxonomy Id: 273116
Other names: T. volcanium GSS1, Thermoplasma volcanium GSS1, Thermoplasma volcanium str. GSS1, Thermoplasma volcanium strain GSS1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TVG0192666	TVG0751384	gene:9380957	gene:9381536	Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	4-hyroxybenzoate octaprenyltransferase.	0.958
TVG0192666	TVG1046096	gene:9380957	gene:9381816	Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	Cofactor biosynthesis protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.	0.907
TVG0192666	TVG1579590	gene:9380957	gene:9382337	Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	Hypothetical protein.	0.907
TVG0211687	TVG0212495	gene:9380975	gene:9380976	ABC transport system permease protein P1P2A.	ABC transport system permease protein P1P2A.	0.997
TVG0211687	TVG0213590	gene:9380975	gene:9380977	ABC transport system permease protein P1P2A.	ABC transport system ATP-binding protein P1P2A.	0.968
TVG0211687	TVG1198021	gene:9380975	gene:9381971	ABC transport system permease protein P1P2A.	ABC transport system permease protein SP1P2A.	0.975
TVG0211687	TVG1199143	gene:9380975	gene:9381972	ABC transport system permease protein P1P2A.	ABC transport system ATP-binding protein SP1P2A.	0.700
TVG0212495	TVG0211687	gene:9380976	gene:9380975	ABC transport system permease protein P1P2A.	ABC transport system permease protein P1P2A.	0.997
TVG0212495	TVG0213590	gene:9380976	gene:9380977	ABC transport system permease protein P1P2A.	ABC transport system ATP-binding protein P1P2A.	0.967
TVG0212495	TVG1197131	gene:9380976	gene:9381970	ABC transport system permease protein P1P2A.	ABC transport system permease protein SP1P2A.	0.974
TVG0212495	TVG1199143	gene:9380976	gene:9381972	ABC transport system permease protein P1P2A.	ABC transport system ATP-binding protein SP1P2A.	0.668
TVG0213590	TVG0211687	gene:9380977	gene:9380975	ABC transport system ATP-binding protein P1P2A.	ABC transport system permease protein P1P2A.	0.968
TVG0213590	TVG0212495	gene:9380977	gene:9380976	ABC transport system ATP-binding protein P1P2A.	ABC transport system permease protein P1P2A.	0.967
TVG0213590	TVG1197131	gene:9380977	gene:9381970	ABC transport system ATP-binding protein P1P2A.	ABC transport system permease protein SP1P2A.	0.716
TVG0213590	TVG1198021	gene:9380977	gene:9381971	ABC transport system ATP-binding protein P1P2A.	ABC transport system permease protein SP1P2A.	0.712
TVG0213590	TVG1199143	gene:9380977	gene:9381972	ABC transport system ATP-binding protein P1P2A.	ABC transport system ATP-binding protein SP1P2A.	0.907
TVG0296872	TVG1506668	gene:9381060	gene:9382268	Iron III dicitrate transport system permease protein.	ABC transport system ATP-binding protein.	0.999
TVG0487282	TVG0489285	gene:9381282	gene:9381283	K+-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.	K+-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.	0.999
TVG0487282	TVG0489908	gene:9381282	gene:9381284	K+-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.	K+-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.	0.999
TVG0489285	TVG0487282	gene:9381283	gene:9381282	K+-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.	K+-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.	0.999