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uvrA uvrA hsdR hsdR UU088 UU088 recA recA gyrA gyrA gyrB gyrB dnaB dnaB whiA whiA UU067 UU067 dnaA dnaA topA topA ssb ssb dnaN dnaN uvrD uvrD dnaG dnaG parC/gyrA parC/gyrA ruvA ruvA dinB dinB polA polA fpg fpg tnp-2 tnp-2 mraZ mraZ rpoD rpoD greA greA UU295 UU295 UU290 UU290 hupA hupA xerC xerC ripX ripX p115 p115
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrAExcinuclease ABC sununit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
hsdRType I restriction enzyme R protein; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1045 aa)
UU088Conserved hypothetical; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa)
recARecombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (334 aa)
gyrADNA topoisomerase chain A - DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an [...] (840 aa)
gyrBDNA topoisomerase - DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depe [...] (650 aa)
dnaBReplicative DNA helicase. (486 aa)
whiAConserved hypothetical; Involved in cell division and chromosome segregation. (330 aa)
UU067Unique hypothetical. (204 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (457 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (677 aa)
ssbSingle-strand binding protein. (166 aa)
dnaNDNA pol III beta chain. (379 aa)
uvrDDNA helicase II. (743 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (641 aa)
parC/gyrATopoisomerase IV subunit A. (850 aa)
ruvAHolliday-junction binding protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (195 aa)
dinBConserved hypothetical; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa)
polADNA polymerase I: 5'-3' exonuclease domain protein; 5'-3' exonuclease acting preferentially on double-stranded DNA. (289 aa)
fpgformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (275 aa)
tnp-2Integrase-recombinase protein; Required for the transposition of the insertion element. (268 aa)
mraZConserved hypothetical; Belongs to the MraZ family. (145 aa)
rpoDRNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (448 aa)
greATranscription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa)
UU295Conserved hypothetical. (236 aa)
UU290Unique hypothetical. (196 aa)
hupADNA-binding protein Hu-alpha (HU-2); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (130 aa)
xerCIntegrase-recombinase protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. (250 aa)
ripXIntegrase-recombinase protein; Belongs to the 'phage' integrase family. (260 aa)
p115P115 protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (981 aa)
Your Current Organism:
Ureaplasma parvum
NCBI taxonomy Id: 273119
Other names: U. parvum serovar 3 str. ATCC 700970, Ureaplasma parvum serovar 3 str. ATCC 700970, Ureaplasma parvum serovar 3 strain ATCC 700970, Ureaplasma urealyticum ATCC 700970
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