STRINGSTRING
GLYA3 GLYA3 dctA dctA pyrF pyrF PYRE PYRE PURB PURB PURF PURF PYRB PYRB purQ purQ purS purS PURC PURC purL purL PURD PURD PURN PURN PYRC2 PYRC2 PUR PUR PURH PURH PYRC PYRC CARA CARA PURA PURA PURE PURE CARB CARB PURM PURM PYRD PYRD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLYA3SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE)(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
dctAURACIL PERMEASE. (415 aa)
pyrFOROTIDINE 5'-PHOSPHATE DECARBOXYLASE; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (228 aa)
PYREPUTATIVE OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (205 aa)
PURBADENYLOSUCCINATE LYASE; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (442 aa)
PURFAMIDOPHOSPHORIBOSYLTRANSFERASE; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (458 aa)
PYRBASPARTATE CARBAMOYLTRANSFERASE; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa)
purQGLYCINAMIDINE SYNTHETASE; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of th [...] (218 aa)
purSMSL0067 PROTEIN; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia [...] (80 aa)
PURCPHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; Belongs to the SAICAR synthetase family. (236 aa)
purLPHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (733 aa)
PURDPHOSPHORIBOSYLAMINE--GLYCINE LIGASE; Belongs to the GARS family. (419 aa)
PURNPHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa)
PYRC2PUTATIVE DIHYDROOROTASE. (396 aa)
PURPHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE-FORMATE DEPENDENT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa)
PURHPHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE / IMPCYCLOHYDROLASE. (510 aa)
PYRCDIHYDROOROTASE DHOASE; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (337 aa)
CARACARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN; Belongs to the CarA family. (377 aa)
PURAADENYLOSUCCINATE SYNTHETASE IMP-ASPARTATE LIGASEADSS AMPSASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (415 aa)
PUREPHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
CARBCARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN; Belongs to the CarB family. (1089 aa)
PURMPHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE. (336 aa)
PYRDDIHYDROOROTATE DEHYDROGENASE; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (353 aa)
Your Current Organism:
Wolinella succinogenes
NCBI taxonomy Id: 273121
Other names: W. succinogenes DSM 1740, Wolinella succinogenes DSM 1740
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.